Keywords

  • biotechnology
  • DNA materials
  • DNA nanotechnology
  • drug delivery
  • environmental tracing
  • genomics and proteomics
  • materials
  • molecular sensing
  • nanobarcodes
  • nanobiotechnology
  • nanocrystals
  • nanoparticles
  • nanopatterning and nano-painting
  • nanophotonics
  • nanowires
  • nucleic acid engineering

Luo, Dan

Associate Professor
Dr. Dan Luo is an associate professor of Biological Engineering in the Department of Biological and Environmental Engineering at Cornell University. He currently is also a faculty member in Nanobiotechnology center, Cornell Center for Materials Research, Kavli Institute for Nanoscale Science, Biomedical Engineering Program and New Life Science Initiatives at Cornell. Dr. Luo obtained his BS degree from the University of Science and Technology of China (USTC) with an undergraduate thesis on molecular dynamics computer simulation. He received his PhD in 1997 from The Ohio State University in the Molecular, Cellular, and Developmental Biology program, working on topoisomerases and DNA networking. After a postdoctoral training in the School of Chemical Engineering at Cornell focusing on polymers and synthetic DNA delivery systems, he joined Cornell faculty in 2001. The overall goal of Luo’s research is the development of Biological Engineering at the molecular level by integrating molecular biology with engineering. More specifically, his research group is currently concentrating on engineering biomacromolecules, DNA for example, into useful, novel materials for nanotechnological, biological, and biomedical applications. Dr. Luo is an Editorial Board Member for “Nanomedicine”, “Nano Today”, and also for "Open Biotechnology". In 2006, Dr. Luo was awarded National Science Foundation’s CAREER award (2006), New York State Foundation for Science, Technology and Innovation (NYSTAR) Technology Transfer Incentive Program Award (2005) and Faculty Development Program Award (2007), and Cornell Provost`s Award for Distinguished Scholarship (2007). More information can be found on his website: http://luolabs.bee.cornell.edu.

research

research areas

submitted impact statement

affiliations

faculty appointment in

member of graduate field

other Cornell affiliations

background

educational background

  • Ph.D. Molecular, Cellular, and Developmental Biology, The Ohio State University, Aug. 1997
  • B.S. Department of Biological Sciences, University of Science and Technology of China, Hefei, Anhui, P. R. of China, 1989

awards and distinctions

  • National Science Foundation CAREER Award (2006)
  • Recognized as one of the “Cornell inventors recognized for contributions to the university and the world” during fiscal year 2005-2006 (2006)
  • Invited to be a conference co-chair for Materials Today Asia Conference (in charge of Interface between Materials and Biology). Sept. 2007
  • Selected by the National Academies as 1 of 100 scientists and engineers nation wide to attend the 3rd Annual National Academies Keck Futures Initiative conference “The Genomic Revolution: Implications for Treatment and Control of Infectious Disease”. Nov. 2005
  • Selected by the National Academies as 1 of 100 scientists and engineers nation wide to attend the 2nd Annual National Academies Keck Futures Initiative conference “Designing Nanostructures at the Interface between Biomedical and Physical Systems”. Nov. 2004
  • Invited to be a co-organizer for NATO’s Advanced Research Workshop (Kiev) on Integrated Nanosystem in Biosensing and Biodetection. May 2005
  • “Cornell University Outstanding Educator” for having most influenced a Merrill Presidential
    Scholar, May 2003
  • Honorary member, Alpha Epsilon (The Honor Society of Agricultural, Food, and Biological Engineering), 2002
  • Poster picks for exceptional research in “28th International Symposium on Controlled Release of Bioactive Materials” in the Gene Delivery session (co-authors: S. Ma, A. Hua, W.M. Saltzman) and in the Microfabrication session (co-authors: S. Tanksley, W.M. Saltzman), San Diego, California, 2001

publications

selected publications (listing in progress)

Papers (excluding abstracts and conference proceedings)
1. S. Um, J. Lee, N. Park, S. Kwon, C. Umbach, D. Luo, Enzyme catalyzed assembly
of DNA hydrogels, Nature Materials 5, 797-801 (2006)


2. S. Um, J. Lee, S. Kwon, D. Luo, DNA nanobarcodes, Nature Protocols 1, 995-1000
(2006)


3. Y. Li, D. Luo (invited author), Multiplexed molecular detection using encoded
nanoparticles, Expert Review of Molecular Diagnostics 6(4), 567-574, (2006)


4. C.A.H. Prata, P. Barthelemy, Y. Li, D. Luo, T.J. McIntosh, Lee SJ, M.W. Grinstaff,
Charge-resersible lipids for DNA delivery, FASEB Journal 20 (4): A73-A73, (2006)


5. D. Luo and W.M. Saltzman (invited authors), Thinking of Silica, 13 (7): 585-586
Gene Therapy (2006)


6. D. Luo (invited author), Nanotechnology and DNA delivery, MRS Bulletin, Sept.
(2005)


7. Y. Li and D. Luo (invited author), High Throughput Codes for Molecular Detections:
From Millimeter to Nanometer. BioForum Europe, (2005)


8. S. M. Stavis, J.B. Edel, Y. Li, K.D. Samiee, D. Luo, H.G. Craighead, Single-molecule
mobility and spectral measurements in submicrometer fluidic channels J. Appl.
Phys. 98, 044903 (2005)


9. Y. Li, Y. Cu and D. Luo, DNA fluorescence nanobarcodes for multiplexed pathogen
detection, Nature Biotechnology 23, 885-889 (2005)

10. L. Moreau, P. Barthélémy, Y. Li, D. Luo, and M.W. Grinstaff, Nucleoside
Phosphocholine Amphiphile for in vitro DNA transfection, Molecular BioSystems 1
(3), 260-4 (2005)


11. K.O. Freedman, J. Lee, Y. Li, D. Luo, V.B. Skobeleva, and P.C. Ke, Diffusion of
Single Star-Branched Dendrimer-Like DNA, J. of Phys. Chem. B. 109, 9839-9842
(2005)


12. S.M. Stavis, J.B. Edel, Y. Li, K.T. Samiee, D Luo and H.G. Craighead, Detection
and identification of nucleic acid engineered fluorescent labels in submicrometer
fluidic channels, Nanotechnology, 16, s314-s323 (2005)


13. R. A. Gemeinhart, D. Luo, and W. M. Saltzman, Cellular fate of a modular DNA
delivery system mediated by silica nanoparticles, Biotechnology Progress, 21, 532-
537(2005)


14. C.A.H. Prata, Y. Zhao, P. Barthélémy, Y. Li, D. Luo, T.J. McIntosh, S.J. Lee, and
M.W. Grinstaff. Charge-reversal amphiphiles for gene delivery. J Am Chem Soc
126(39): 12196-7 (2004)


15. Y. Li, Y.D. Tseng, S.Y. Kown, L. d’Espaux, J.S. Bunch, P.L McEuen and D. Luo.
Controlled assembly of dendrimer-like DNA. Nature Materials, 3, 38-42 (2004).


16. D. Luo, E. Han, N. Belcheva and W. Mark Saltzman, A self-assembled, modular
DNA delivery system mediated by silica nanoparticles J. of Control. Release. 95,
333-341 (2004)


17. D. Luo. A new solution to improved gene therapy. Trends in Biotechnology. 22, 101-
103 (2004)


18. D. Luo. The road from biology to materials. Materials Today, 6, 38-43 (2003)


19. D. Luo and W.M. Saltzman, Somatic Cell and Molecular Genetics, 27, 1-3 (2002)


20. D. Luo, K. Haverstick, N. Belcheva, E. Han and W.M. Saltzman. Poly(ethylene
glycol)-conjugated dendrimer for biocompatible and high efficient DNA delivery,
Macromolecules, 35, 3456-3462 (2002)


21. D. Luo and W.M. Saltzman. Enhancement of transfection by physical concentration
of DNA at the cell surface, Nature Biotechnology, 18, 893-895 (2000)


22. D. Luo and W.M. Saltzman. Synthetic DNA delivery systems, Nature Biotechnology,
18, 33-37 (2000)


23. D. Luo, K. Woodrow-Mumford, N. Belcheva and W.M. Saltzman. Controlled DNA
delivery systems, Pharmaceutical Research, 16, 1299-1307 (1999)


24. F. Hung, D. Luo, M. Sauve, M.T. Muller and M. Roberge. Characterization of
topoisomerase II-DNA interaction and identification of a DNA-binding domain by
ultraviolet laser crosslinking, FEBS Letters, 380, 127-132 (1996)


Books


25. D. Luo (Series Editor) Nano-medicine, Pan Stanford Publishing, (2006-)


26. D. Luo (Editor), Nucleic Acid Engineering, Publisher: (Taylor and Francis Books or
Springer), In preparation (2007)


27. D. Luo, Textbook: Molecular and Cellular BioEngineering: Principles and
Applications In preparation (expected finishing date: Nov. 2005)


28. J. Y. Wong, etc. (D. Luo is one of the editors), Architecture and Application of
Biomaterials and Biomolecular Materials, Symposium Proceedings, Publisher:
Materials Research Society, ISBN: 1-55899-745-8, (2004).


29. D. Luo (Editor) and W.M. Saltzman (Editor). Synthetic DNA Delivery Systems. Copublished
by Kluwer Academic Publishers and Landes Biosciences. ISBN:
0306477017, (2003)


Book Chapters
30. D. Luo (invited author), H. Funabashi, and S.H. Um: Nucleic Acid Engineering:
towards synthetic biology in Systems Biology and Synthetic Biology, Wiley, expected
in 2007


31. D. Luo (invited author), Y. Cu, Y. Li and S. Um, Dendrimer-like DNA for DNA
vaccination, in DNA Vacccines, Editor: W.M. Saltzman et al. ISBN 1-58829-484-6
(2006)


32. D. Luo (invited author) and Y. Li, Nucleic Acid Engineered Nanobiomaterials, in
“Handbook of Nanostructured Biomaterials and Their Applications in
Nanobiotechnology”, Editor, H. S. Nalwa, American Scientific Publisher, ISBN
1588830330 (2005)


33. D. Luo (invited author), DNA delivery systems in “McGraw-Hill Yearbook of Science
and Technology”, pg. 93-95, 2003, an annual companion book to the “McGraw-Hill
Encyclopedia of Science and Technology” McGraw-Hill, Inc. Publisher (2003)


34. D.C. Jaworski, A.C. LaDu, D. Luo, M.T. Muller and G.R. Needham. The role of
Calreticulin in parasitic associations, Acarology IX: Symposia, Vol. 2, Editors: G.R.
Needham, R. Mitchell, D.J. Horn and W.C. Welbourn (1999)

Patents
35. D. Luo and S. Um, DNA-hydrogels, patent filed (2006)

36. D. Luo and H. Funabashi, A rolling-circle production of branched DNA. Patent
pending (2006)

37. D. Luo and S. Um, A cell-free protein producing gel. Patent pending (2006)

38. D. Luo and Y. Li, DNA nanobarcodes. Patent filed (2006)

39. D. Luo and Y. Li. Molecular Assembly of Dendrimer-Like DNA Nanoparticles.
Disclosure filed (D-3075), Cornell University Research Foundation. Patent pending
(April 2002). US Patent No. 7,223,544 (May, 2007)

40. D. Luo, E. Han, N. Belcheva and W.M. Saltzman. Method of enhancing the delivery
of nucleic acids using nanoparticles. US Patent No. 6,319,715 (Nov. 2001)

41. D. Luo, K. Woodrow-Mumford, N. Belcheva, H. Shen and W.M. Saltzman. DNA
controlled release systems. US Patent App. No. 09/616,711. (2000)

42. D. Luo, N. Belcheva and W.M. Saltzman. Poly(ethylene glycol)-conjugated
dendrimer for biocompatible, high efficient, and low cost DNA delivery. Patent
disclosed. (2000)

43. D. Luo and M.T. Muller. Biotin-Avidin-Networked-Genes (BANG) system for overexpression
and cloning. US Patent App. No. 09/244,722. (1998)

speaker at Cornell event

Keywords: biotechnology, DNA materials, DNA nanotechnology, drug delivery, environmental tracing, genomics and proteomics, materials, molecular sensing, nanobarcodes, nanobiotechnology, nanocrystals, nanoparticles, nanopatterning and nano-painting, nanophotonics, nanowires, nucleic acid engineering