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• Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresome
• A novel RING-finger protein complex essential for a late step in protein transport to the yeast vacuole
• A peripheral mitochondrial inner membrane protein, Mss2p, required for export of the mitochondrially coded Cox2p C-tail in Saccharomyces cerevisiae
• A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization
• A rho-GAP, encoded by BEM2, regulates microfilaments in yeast
• A role for calmodulin in organelle membrane tubulation
• A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein sorting receptor
• Alteration of the Saccharomyces cerevisiae COX2 mRNA 5’-untranslated leader by mitochondrial gene replacement and functional interaction with the translational activator protein PET111
• An MBoC Favorite: Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA.
• Analysis of unregulated formin activity reveals how yeast can balance F-actin between different microfilament-based organizations
• Assessing local diffusion of calmodulin in neurons using multiphoton fluorescence photobleaching recovery (MPFPR) and fluorescence correlation spectroscopy (MPFCS).
• Atg18 regulates organelle morphology and fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate
• Axon and dendrite growth and differentiation can be controlled by nanofabricated surface features
• C. elegans nuclear envelope proteins Emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis
• CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos
• Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresome
• Chromosome loss, hyperrecombination, and cell cycle arrest in a yeast mcm1 mutant
• Constitutive dynein activity in she1 mutants reveals differences in microtubule attachment at the yeast spindle pole body.
• Coupling of the thrombin receptor to G(12) may account for selective effects of thrombin on gene expression and DNA synthesis in 1321N1 astrocytoma cells
• Cox18p is required for export of the mitochondrially encoded Saccharomyces cerevisiae Cox2p C-tail, and interacts with Pnt1p and Mss2p in the inner membrane
• Depletion of Phosphatidylcholine in Yeast Induces Shortening and Increased Saturation of the Lipid Acyl Chains: Evidence for Regulation of Intrinsic Membrane Curvature in a Eukaryote
• Direct interaction of v-Src with the focal adhesion kinase mediated by the SH2 domain
• Distinct roles for the yeast PtdIns 4-kinases, Stt4p and Pik1p, in secretion, cell growth and organelle dynamics
• Drosophila Mcm10 interacts with members of the pre-replication complex and is required for proper chromosome condensation
• Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria.
• Effects of substrate geometry on growth cone behaviour and axon branching
• Emerin and LEM2: essential roles in C. elegans development, muscle function and mitosis
• Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2P and Sjl3P in the regulation of phosphatidylinositol 3-phosphate in yeast
• Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression and spatial organization of nuclear pore complexes
• Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
• Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters
• Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that Associates with the actin cytoskeleton of Placental Microvilli
• Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking
• Inhibition of membrane tubule formation and trafficking by isotetrandrine, an antagonist of G-protein regulated phospholipase A2 enzymes
• Interactions among COX1, COX2 and COX3 mRNA-specific translational activator proteins on the inner surface of the mitochondrial inner membrane of Saccharomyces cerevisiae
• Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans
• Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase
• Mcm2 and Mcm3 are constitutive nuclear proteins that exhibit distinct isoforms and bind chromatin during specific cell cycle stages of S. cerevisiae
• Mechanisms governing the activation and cell-surface targeting of yeast G protein-coupled receptors
• Membrane translocation of mitochondrially coded Cox2p: distinct requirements for export of amino- and carboxy-termini, and dependence on the conserved protein Oxa1p
• Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists
• Multivesicular body sorting: Ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S
• Novel Ist-1-Did2 complex functions at a late step in MVB sorting.
• Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast
• Phospholipase A2 antagonists inhibit nocodazole-induced Golgi mini-stack formation: evidence for an ER-intermediate and constitutive recycling
• Polarized growth in budding yeast in the absence of a localized formin
• Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway
• Regulated phosphorylation of budding yeast's essential myosin V heavy chain, Myo2p
• Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member
• Regulation of Greatwall kinase during Xenopus oocyte maturation
• Regulation of microtubule dynamics by Bim1 and Bik1, the budding yeast members of the EB1 and CLIP-170 families of plus-end tracking proteins.
• Role of microfabricated structures on attachment and growth of neurons and astrocytes
• Roles of Greatwall kinase in the regulation of Cdc25 phosphatase
• Sac1 lipid phosphatase and Stt4 PtdIns 4-kinase regulate a pool of PtdIns(4)P that functions in the control of the actin cytoskeleton and vacuole morphology
• Stable and dynamic axes of polarity utilize distinct forming isoforms in budding yeast
• Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle
• Synthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway
• Systematic mutational analysis of the yeast beta-tubulin gene
• The Drosophila nuclear protein YA binds to DNA and histone H2B with four domains
• The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites
• The Yeast Synaptojanin-like proteins control the cellular distribution of phosphatidylinositol(4,5)-bisphosphate
• The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function and localization
• The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast
• The phospholipase A2 enzyme complex PAFAH Ib mediates endosomal membrane tubule formation and trafficking.
• The regulation of microtubule dynamics in Saccharomyces cerevisiae by three interacting plus-end tracking proteins
• The role of topographical cues on the development of rat hippocampal neuron polarity and synapse formation in vitro
• The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures
• Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway
• Vacuole size control: Regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase
• Yeast GGA Proteins Function with Clathrin in Golgi to Endosome Transport
• Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation
• Yeast formin Bni1p has multiple localization regions that function in polarized growth and spindle orientation.