We need to know if areas of genomes that are subject to large amounts of crossing-over are places where new mutations might arise at high frequencies. This will affect the efficacy of selective breeding regimes.
We have set up an experimental system where we can select for the survival of recombinants and recover them in large numbers. We have also demonstrated and measured the rate of recombination within a repeated region of the gene we are using as a model system.
This is basic research. Demonstrating a regional basis for the quantitave induction of new mutations will guide future breeding programs, however.
Selection of new variants
funding source description
National Institutes of Health
National Science Foundation
New York State Department of Agriculture and Markets