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Batt, Carl A.
Cornell Faculty Member
Positions
Many of the problems we face require an interdisciplinary approach and innovations on established technology in order to be solved. Our group consists of individuals with a broad set of skills and understanding, enabling us to tackle projects of a very complex nature. Collaborators here at Cornell University and numerous other academic, industrial, and governmental institutions throughout the world provides are part of this exciting community. Our work strives to provide advancements in basic scientific research that will have a direct impact on society at large. Our scientists, including graduate students and post docs, also work with the community to promote scientific understanding of students of all ages.
Research Areas
- biomedical instrumentation and diagnostics
- microbiology
- nanobiotechnology
- nanotechnology
- pathogens
- pest management
- plant sciences
- science and technology studies
- science education
- teacher education
Websites
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Affiliations
other Cornell affiliations
Research
research overview
- Our laboratory is engaged in basic and applied research in a wide range of topics. One area of focus in on the use of protein engineering / expression techniques for developing recombinant anti-cancer therapeutics. Another active area of research involves the design and engineering of portable sensor devices using leading-edge micro- and nanofabrication methods. The third major area of investigation in our lab explores how biomaterials may be used to develop novel methodologies for creating advanced microfluidic systems and nanostructured arrays for bioanalytical applications. More detailed descriptions of some of our specific projects may be found our Research section.
principal investigator on
- A MICROCHIP PCR-BASED BIOSENSOR FOR THE DETECTION OF CRONOBACTER awarded by FOREIGN AGRICULTURAL SERVICE USDA 2009 - 2012
- CANCER VACCINE COLLABORATIVE GRANT FOR THE PRODUCTION OF MELAN-A awarded by CANCER RESEARCH INSTITUTE 2010 - 2012
- FERMENTATION OPTIMIZATION OF ASPERGILLUS: ALLOCATION OF RIGHTS AGREEMENT awarded by US ARMY 2011 - 2014
- NANO PUBLIC PERCEPTION awarded by NATIONAL INSTITUTE OF FOOD AND AGRICULTURE-USDA 2008 - 2012
- NANOOZE: AN EXHIBIT FOR IYC 2011 awarded by DIRECTORATE FOR BIOLOGICAL SCIENCES NSF 2011 - 2012
- NANOPARTICLE BASED INTRACELLULAR SENSING OF ORGANOPHOSPHATES'TATTOO' awarded by US DEPT OF DEFENSE 2012
- STAND-OFF SERS DETECTION USING NANOPARTICLES awarded by NATIONAL INSTITUTE OF FOOD AND AGRICULTURE-USDA 2009 - 2012
area(s) of concentration/expertise
other area(s) of concentration/expertise
- Microbiology, Nanobiotechnology, Genetic Engineering
keywords
- Anti-cancer
- Cancer Research
- Protein
submitted impact statement
Publications
individual publications
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academic article
- A proteomic analysis of the Pichia pastoris secretome in methanol-induced cultures. Applied Microbiology and Biotechnology. 90:235-247. 2011
- Determining the efficacy of a nanotechnology media product in enhancing children’s engagement with nanotechnology. Journal of Nanoparticle Research. 13:6291-6295. 2011
- Expression and purification of a cGMP grade NY-ESO-1 for clinical trials. Biotechnology Progress. 27:435-441. 2011
- Hydrodynamic optical alignment for microflow cytometry. Lab Chip. 11:1138-1143. 2011
- PAA-derived gold nanorods for cellular targeting and photothermal therapy. Macromolecular Bioscience. 11:779-788. 2011
- PCR-based detection of Bacillus anthracis using an integrated microfluidic platform. Journal of Biomedical Nanoscience and Nanotechnology. 2:152-166. 2011
- Protein secretion in Pichia pastoris and advances in protein production. Applied Microbiology and Biotechnology. 93:31-9. 2011
- Entropically driven self-assembly of Lysinibacillus sphaericus S-layer proteins analyzed under various environmental conditions. . Macromolecular Bioscience. 10:147-155. 2010
- Epitaxy of Ge Nanowires Grown from Biotemplated Au Nanoparticle Catalysts. ACS Nano. 4:1209-1217. 2010
- Gold hybrid nanoparticles for targeted phototherapy and cancer imaging. Nanotechnology. 21:105105. 2010
- Improved secretion of cancer-testis antigen, SSX2 in Pichia pastoris by deletion of its nuclear localization signal. Applied Microbiology and Biotechnology. 86:243-253. 2010
- In vitro self-assembly of gold nanoparticle-coated poly(3-hydroxybutyrate) granules exhibiting plasmon-induced thermo-optical enhancements. ACS Applied Materials and Interfaces. 2:1804-1810. 2010
- Low-power microfluidic electro-hydraulic pump (EMP). Lab on a Chip. 10:74-79. 2010
- Multiplex single nucleotide polymorphism genotyping utilizing ligase detection reaction couple surface enhanced Raman spectroscopy. Analytical Chemistry. 82:5810-5814. 2010
- Multiplexed protein patterns on a photosensitive hydrophilic polymer matrix. Advanced Materials. 22:1242-1246. 2010
- Paradoxical glomerular filtration of carbon nanotubes. Proceedings at the National Academy of Science USA. 107:12369-12374. 2010
- Recombinant immunotherapeutics: current state and perspectives regarding the feasibility and market. Applied Microbiology and Biotechnology. 87:401-410. 2010
- Detection of carbendazim by surface enhanced Raman scattering using cyclodextrin inclusion complexes on gold nanorod. Anal. Chem. 81:2895-2903. 2009
- Diacetylene Phospholipid-Mediated Synthesis of Germania Nanotubules and Nanoparticles. Chem. Mater.. 21. 2009
- Factors affecting the endotoxin removal from recombinant therapeutic proteins by anion exchange chromatography. Prot. Exp. Purif. 64:76-81. 2009
- High-level expression of a phage display-derived scFv in Pichia pastoris. . Methods in Molecular Biology. 225-236. 2009
- Hydrodynamic focusing with a microlithographic manifold: controlling the vertical position of a focused sample.. Journal of Microfluidics. 7:569-578. 2009
- Nucleic acid-based detection of bacterial pathogens using integrated microfluidic platform systems. Sensors. 9:3713-3744. 2009
- Surface enhanced Raman scattering based ligase detection reactio. Journal of American Chemical Society. 131. 2009
- Biotemplated nanostructured materials. Chemical Materials. 20:821-834. 2008
- Development of a mast cell-based biosensor. Biosensors and Bioelectronics. 23:1024-1031. 2008
- Numbers, scale and symbols: The public understanding of nanotechnology. Journal of Nanoparticle Research. 10:1141-1148. 2008
- Substrate selective patterning on lithography defined gold on silica: Effect of end-group functionality on intermolecular layer formation . Surface Science. 602:2121-2127. 2008
- Synthesis and biodistribution of oligo-nucleotide functionalized, tumor-targetable carbon nanotubes. American Chemical Society - Nano Letter. 8. 2008
- Thinking small is not easy. Nature Nanotechnology. 3:121-122. 2008
- Vertical growth of Ge nanowires from biotemplated Au nanoparticle catalysts. Journal of the American Chemical Society. 130:10488-10489. 2008
- A Facile Preparative Method for Aggregation-Free Gold Nanoparticles Using Poly(styrene-block-cysteine). Angewandte Chemie. 46:5720-5723. 2007
- A plastic microchip for nucleic acid purification. Biomedical Microdevices. 9:769-776. 2007
- Co-overexpression of chaperones for enhanced secretion of a single-chain antibody fragment in Pichia pastoris. Applied Microbiology and Biotechnology. 74:381-389. 2007
- Expression and purification of a cancer antigen SSX2: A potential cancer vaccine. Protein Expression and Purification. 56:212-219. 2007
- Insight in the role of bovine serum albumin for promoting the in situ surface growth of polyhydroxybutyrate (PHB) on patterned surfaces via enzymatic surface-initiated polymerization. Colloids and Surfaces B: Biointerfaces. 60:68-79. 2007
- Integrated reactive ion etching to pattern cross-linked hydrophilic polymer structures for protein immobilization. Applied Physics Letters. 90:144107-144109. 2007
- Nanoporous S-Layer protein lattices: A biological ion gate with calcium selectivity. Journal of Physical Chemistry. 111:13232-13237. 2007
- Near-infrared fluorescence imaging with water-soluble lead salt quantum dots. Journal of Physical Chemistry B. 111:5726-5730. 2007
- New biodegradable polyhydroxybutyrate/layered silicate nanocomposites. Biomacromolecules. 8:3393-3400. 2007
- Optimized linkage and quenching strategies for quantum dot molecular beacon. Molecular and Cellular Probes. 21:116-124. 2007
- PET imaging of soluble yttrium-86-labeled carbon nanotubes in mice. PLoS One. 2. 2007
- Synthesis of stable “gold nanoparticle-polymeric micelle” conjugates: A new class of star “molecular chimera” that self assemble into linear arrays of spherical micelles. Journal of Polymer Science Part A: Polymer Chemistry. 45:3570-3579. 2007
- Thin film processing using S-layer proteins: Biotemplated assembly of colloidal gold etch masks for fabrication of silicon nanopillar arrays. Colloids and Surfaces B: Biointerfaces.. 57:161-173. 2007
- Bionanofabrication of metallic and semiconductor nanoparticle arrays using S-layer protein lattices with different lateral spacings and geometries. Langmuir. 22:3763-3774. 2006
- Carbon nanotubes in biomedical applications. Nanotechnology Law & Business. 3:263-292. 2006
- Comparative study of promoters for the production of polyhydroxyalkanoates in recombinant strains of Wautersia eutropha. Applied Microbiology and Biotechnology. 71:668-679. 2006
- Dendrimer-scaffold-based electron-beam patterning of biomolecules. Advanced Materials. 18:315-319. 2006
- Evaluation of Mut(+) and Mut(S) Pichia pastoris phenotypes for high level extracellular scFv expression under feedback control of the methanol concentration. Biotechnology Progress. 22:881-888. 2006
- Evaluation of Mut+ and MutS Pichia pastoris phenotypes for high level extracellular scFv expression under feedback control of the methanol concentration. Biotechnology Progress. 22:881-888. 2006
- Lowering the pH optimum of D-xylose isomerase: the effect of mutations of the negatively charged residues. Mol. Cell. 8:74-384. 2006
- Real-time analysis of enzymatic surface-initiated polymerization using surface plasmon resonance (SPR). Macromolecular Bioscience. 6:145-152. 2006
- Real-time analysis of enzymatic surface-initiated polymerization using surface plasmon resonance (SPR). Macromolecular Bioscience. 6:145-152. 2006
- Self-Assembly of dendrimer-encapsulated nanoparticle arrays using 2-D microbial S-layer protein biotemplates. Biomacromolecules. 7:1884-1897. 2006
- The current state of public understanding of nanotechnology. Journal of Nanoparticle Research. 8:569-575. 2006
- Effect of nanoparticle mobility on toughness of polymer composites. Advanced Materials. 17:525-528. 2005
- Effect of nanoparticle mobility on toughness of polymer nanocomposites. Advanced Materials. 17. 2005
- End functionalization of poly (3-hyrdroxybutyrate) via genetic engineering for solid surface modification. Chemical Communications. 15:1956-1958. 2005
- Hands-on classroom photolithography laboratory to explore nanotechnology. Journal of Chemical Education. 82:1361-1364. 2005
- Identification and characterization of two polyhydroxyalkanoate biosynthesis loci in Pseudomonas sp. strain 3Y2. Applied Microbiology and Biotechnology. 69:293-303. 2005
- Real-time PCR detection of Listeria monocytogenes using an integrated microFLUIDICS platform. Sensors and Actuators B: Chemical. 107:332-341. 2005
- A simple poly(3,4-ethylene dioxythiophene)/poly(styrene sulfonic acid) transistor for glucose sensing at neutral pH. Chemical Communications. 13:1556-1557. 2004
- An optimized fermentation process for high-level production of a single-chain Fv antibody fragment in Pichia pastoris. Protein Expression and Purification. 37:18-26. 2004
- Bionanofabrications of ordered nanoparticle arrays: effect of particle properties and adsorption conditions. Journal of Physical Chemistry. 108:8241-8248. 2004
- Dendrimer-functionalized self-assembled monolayers as a surface plasmon resonance sensor surface. Langmuir. 20:6808-6817. 2004
- Dramatic enhancements in toughness of polyvinylidene fluoride nanocomposites via nanoclay-directed crystal structure and morphology. Advanced Materials. 16:1173-1177. 2004
- Engineering of chimeric class II polyhydroxyalkanoate synthases. Applied and Environmental Microbiology. 70:6789-6799. 2004
- Enzymatic surface-initiated polymerization: A novel approach for the in situ solid-phase synthesis of biocompatible polymer poly(3-hydroxybutyrate). Biomacromolecules. 5:889-894. 2004
- Enzymatic surface-initiated polymerization: A novel approach for the in situ solid-phase synthesis of biocompatible polymer poly(3-hydroxybutyrate). Biomacromolecules. 5:889-894. 2004
- Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines. Biotechnology Progress. 20:1273-1279. 2004
- Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines. Biotechnology Progress. 20:1273-1279. 2004
- Intercalation, delivery, and expression of the gene encoding green fluorescence protein utilizing nanobiohybrids. Journal of Controlled Release. 100:399-409. 2004
- Real-time label-free monitoring of tumor antigen and serum antibody interactions . Journal of Biochemical and Biophysical Methods. 61:283-298. 2004
- Restoration of a defective Lactococcus lactis xylose isomerase. Applied and Environmental Microbiology. 70:4318-4325. 2004
- Too small to see: the promise and the fear of nanotechnology. Pflanzenschutz-Nachrichten Bayer. 57:22-34. 2004
- Nucleic acid purification using microfabricated silicon structures. Biosensors and Bioelectronics. 19:59-66. 2003
- Renewable plastics: Synthesis and properties of PHB nanocomposites.. Abstracts of Papers of the American Chemical Society. 225. 2003
- Reversible unfolding of bovine beta -lactoglobulin mutants without a free thiol group. Journal of Biological Chemistry. 278. 2003
- Amperometric TNT biosensor based on the oriented immobilization of a nitroreductase maltose binding protein fusion. Analytical Chemistry. 74:140-148. 2002
- Enzymatic surface-initiated polymerization of 3-(R)-hydroxybutyryl-CoA: Surface modification of a solid substrate with a biodegradable and biocompatible polymer. Polymer Preprints. 43:706. 2002
- Enzymatic surface-initiated polymerization of 3-(R)-hydroxybutyryl-CoA: Surface modification of a solid substrate with a biodegradable and biocompatible polymer.. Abstracts of Papers of the American Chemical Society. 223. 2002
- Factors affecting the performance of 5' nuclease PCR assays for Listeria monocytogenes detection. Journal of Microbiological Methods. 51:361-368. 2002
- Science and technology centers and education. Science. 297:2208-2209. 2002
- Study of specific binding of maltose binding protein to pyrrole-derived bipyridinium film by quartz crystal microbalance. Langmuir. 18:4892-4897. 2002
- A review of molecular recognition technologies for detection of biological threat agents. Biosensors and Bioelectronics. 15:549-78. 2001
- Characterization of glycosylated variants of β-lactoglobulin expressed in Pichia pastoris. Prot. Engineer. 14:201-207. 2001
- Genetic Evidence for a defective xylan degradation pathway in Lactococcus lactis. Applied Environmental Microbiology. 67:1445-1452. 2001
- High pressure NMR reveals a variety of fluctuating conformers in beta-lactoglobulin. J Mol Biol. 305:1073-1083. 2001
- Native-like betahairpin retained in the cold-denatured state of bovine beta-lactoglobulin. J Mol Biol. 310:471-484. 2001
- Novel Immuno-FRET Assay Method for Bacillus Spores and Escherichia coli O157:H7. Biochem Biophys Res Commun. 287:875-80. 2001
- Single cell detection with micromechanical oscillators . J. Vacuum Science & Technology B: Microelectronics and Nanometer Structures. 19:2825-2828. 2001
- Structural and kinetic characterization of early folding events in beta-lactoglobulin. Nature Structural and Molecular Biology. 8:151-155. 2001
- The β-sheet to α-helix transition of β-lactoglobulin monitored in real-time with a microfabricated IR mixer. Proceedings at the National Academy of Science USA. 98:6646-6649. 2001
- Time resolved collapse of a folding protein observed with small angle x-ray scattering. Physical Review Letters. 86:4962-4965. 2001
- Development of a fluorogenic probe-based PCR assay for detection of Bacillus cereus in nonfat dry milk. Applied Environmental Microbiology. 66:1453-1459. 2000
- Dissolution of xylose metabolism in Lactococcus lactis. Applied Environmental Microbiology. 66:3974-3980. 2000
- Is Folding of β-lactoglobulin non-hierarchic? Intermediate with native-like β-sheet and non-native α-helix. J. Mol. Biol. 296:1039-1051. 2000
- Mechanical resonant immunospecific biological detector. Appl. Phys. Lett. 77:450-453. 2000
- Detection of viable Listeria monocytogenes by a 5' nuclease PCR assay. Applied and Environmental Microbiology. 65:2122-2127. 1999
- Solution structure and dynamics of bovine beta-lactoglobulin A. Protein Science. 11:2541-5. 1999
- The microbiology and historical safety of margarine. Food Microbiology. 16:325-334. 1999
- A risk assessment approach for food-related Bacillus cereus and its toxins. Journal of Applied Microbiology. 84. 1998
- Diffraction-based cell detection using a microcontact printed antibody grating. Analytical Chemistry. 70:1108-11. 1998
- Heteronuclear NMR characterization of the native β-sheet and TFE-induced α-helical states of β-lactoglobulin. J. Mol. Biol. 283:731-739. 1998
- Isotopically labeled bovine β-Lactoglobulin for NMR studies expressed in Pichia pastoris. Prot. Exp. Purif. 14:97-103. 1998
- Molecular cloning and functional expression in Lactobacillus plantarum 80 of xylT, encoding the Dxylose-H+ symporter of Lactobacillus brevis. Applied Environmental Microbiology. 64:4720-4728. 1998
- Production of glucose isomerase in a recombinant strain of Streptomyces lividans. Applied Microbiology and Biotechnology. 50:65-70. 1998
- An outbreak investigation of listeriosis in sheep in New York state. American Journal of Veterinarian Research. 58:733-737. 1997
- Diffractionbased cell detection using a microcontact printed antibody grating. J. Clin Chem. 70:1108-1111. 1997
- Diversity of Streptococcus agalactiae and Staphylococcus aureus ribotypes recovered from New York dairy herds. American Journal of Veterinarian Research. 58:482-487. 1997
- Expression, purification and immunochemical characterization of recombinant bovine beta-lactoglobulin, a major cow milk allergen . Molecular Immunology. 33:1113-1118. 1997
- High level expression of bovine β -lactoglobulin in Pichia pastoris and characterization of its physical properties. Prot. Eng. 10:1339-1345. 1997
- Origin and spread of Listeria monocytogenes in an epizootic of listeriosis in sheep . American Journal of Veterinarian Research. 58:733-737. 1997
- Ribotypes and virulence gene polymorphisms suggest three distinct Listeria monocytogenes lineages with differences in their pathogenic potential. Infect. Immun. 65:2707-2716. 1997
- Strain-specific differentiation of Lactococci in mixed populations using RAPD-derived probes. Applied and Environmental Microbiology. 63:2702-2707. 1997
- A PCR-based assay for the detection of Escherichia coli shiga-like toxin (SLT) genes in ground beef. Applied Environmental Microbiology. 62:1347-1353. 1996
- A solid phase fluorescent capillary immunoassay for the detection of Escherichia coli O157:H7 in ground beef and apple cider. J. Appl. Bacteriol. 81:601-607. 1996
- Bacterial retention and cleanability of plastic and wood cutting boards using commercial foodservice maintenance practice. Journal of Food Protection. 60:407-413. 1996
- Cloning and nucleotide sequence analysis of the equine CU/Zn superoxide dismutase cDNA and it relationship with equine motor neuron disease. Gene. 178:83-88. 1996
- Development of a solid phase fluorescent immunoassay for the detection of Salmonella. Journal of Food Protection. 59:922-927. 1996
- Diversity of Streptococcus agalactiae and Staphylococcus aureus ribotypes recovered from New York dairy herds. American Journal of Veterinarian Research. 58:482-487. 1996
- Expression, purification and immunochemical characterization of recombinant bovine β-lactoglobulin, a major cow milk allergen. Mol. Immunol. 33:1113-1118. 1996
- Molecular diagnostics for dairy-borne pathogens. Journal of Dairy Science. 80:220-229. 1996
- Ribotype diversity of Listeria monocytogenes strains associated with outbreaks of listeriosis in ruminants. Journal of Clinical Microbiology. 34:1086-1090. 1996
- Applications of DNA amplification techniques in veterinary diagnostics. Veterinary Research Communications. 19:375-407. 1995
- Design and implementation of a strategy to reduce bacteriophage infection of dairy starter cultures. Int. J. Dairy. 5:949-962. 1995
- Detection of Listeria monocytogenes in surface swabs using a nonisotopic polymerase chain reaction-coupled ligase chain reaction. Food Microbiology. 12:151-157. 1995
- Development of a molecular detection method for naphthalene degrading Pseudomonads. FEMS Microbiol. Ecol. 18:225-235. 1995
- Effect of cellular physiology on PCR amplification efficiency. Molecular Ecology. 4:11-16. 1995
- Probing the roles of active site residues in D-xylose isomerase. Journal of Biological Chemistry. 270:22895-22906. 1995
- The use of a fluorogenic probe in a PCR-based assay for the detection of Listeria monocytogenes. Applied and Environmental Microbiology. 61:3724-3728. 1995
- Cloning and sequencing of the Lactococcus lactis subsp. lactis LM0230 dnaK gene using a PCR-based approach. Gene. 142:91-96. 1994
- Design improvements of β-lactoglobulin. Trend. Food Sci. 5:261-265. 1994
- Detection of bovine leukocyte adhesion deficiency by nonisotopic ligase chain reaction. Animal Genetics. 25:95-98. 1994
- Diagnosis and epidemiological association of Listeria monocytogenes strains in two outbreaks of listerial encephalitis in small ruminants. Journal of Clinical Microbiology. 32:991-996. 1994
- Diagnosis, epidemiology and characterization of Listeria monocytogenes strains in two outbreaks of listerial encephalitis in small ruminants. Journal of Clinical Microbiology. 32:991-996. 1994
- Food safety applications of nucleic acid-based assays. Food Technol. 48:142-145. 1994
- Identification of Erwinia stewartii by a ligase chain reaction assay. Applied and Environmental Microbiology. 60:278-284. 1994
- Ligase chain reaction (LCR) - Overview and applications. PCR Meth. Appl. (Manual Supplement). 3. 1994
- Perturbing the metal site in D-xylose isomerase: The effect of mutation of His-220 on enzyme stability. Journal of Biological Chemistry. 269:2687-2694. 1994
- Probing the retinol binding site of bovine β-lactoglobulin. Journal of Biological Chemistry. 269:11102-11107. 1994
- Reducing whey syneresis in yogurt by the addition of a thermolabile variant of β-lactoglobulin. Biotechnol. Biochem. 58:309-313. 1994
- Thermostable variants of bovine β-lactoglobulin. Prot. Eng. 7:263-270. 1994
- Verification of causal relationships between Listeria monocytogenes isolates implicated in food-borne outbreaks of listeriosis by randomly amplified polymorphic DNA patterns. Journal of Clinical Microbiology. 32:1280-1287. 1994
- A combined modified reverse dot blot and nested PCR assay for the specific nonradioactive detection of Listeria monocytogenes. Mol. Cell. Probes. 7:199-207. 1993
- A micro-scale method for measuring the hardness of heat induced protein gels. Food Texture. 24:73-79. 1993
- A simple and rapid method for the selection of oligodeoxynucleotide-directed mutants. Meth. Enzymol. 217:280-286. 1993
- Cloning and sequencing the Lactococcus lactis subsp. lactis groESL operon. Gene. 127:121-126. 1993
- Detection of Bovine Herpesvirus-1 in bovine semen by a nested PCR assay. J. Virol. Meth. 44:129-140. 1993
- Detection of Listeria monocytogenes with a nonisotopic polymerase chain reaction-coupled ligase chain reaction assay. Applied and Environmental Microbiology. 59:2743-2745. 1993
- Differentiation of Listeria monocytogenes and Listeria innocua by 16S rDNA and intraspecies discrimination of Listeria monocytogenes strains by random amplified polymorphic DNA polymorphisms. Applied and Environmental Microbiology. 59:304-308. 1993
- Enhancing the gelation of β-lactoglobulin. Journal of Agricultural and Food Chemistry. 41:1343-1348. 1993
- Non-radioactive detection of Mycobacterium tuberculosis LCR products in a microtitre plate format. Mol. Cell. Probes. 7:179-186. 1993
- Polymerase chain reaction amplification of naphthalene catabolic and 16S rRNA gene sequences from indigenous sediment bacteria. Applied and Environmental Microbiology. 59:687-694. 1993
- Antisense RNA directed against the major capsid protein of Lactococcus lactis subsp. cremoris confers resistance to the host strain. Applied Microbiology and Biotechnology. 37:235-240. 1992
- Bacteriophage resistance engineered into a strain of Lactococcus lactis subsp. lactis using antisense ribonucleic acid. Journal of Dairy Science. 75:1761-1767. 1992
- Cloning and nucleotide sequence of the Lactobacillus brevis xylose isomerase. Gene. 114:127-131. 1992
- Fluorescent properties of the Escherichia coli Dxylose isomerase active site. Prot. Eng. 5:235-240. 1992
- Use of antisense mRNA to engineer a bacteriophage resistant lactic acid starter culture. Journal of Industrial Microbiology and Biotechnology. 10:71-78. 1992
- Antisense mRNA mediated bacteriophage resistance in Lactococcus lactis. Applied Environmental Microbiology. 57:1109-1113. 1991
- Characterization of the heat shock response in Lactococcus lactis ssp. lactis. Applied Environmental Microbiology. 57:14081412. 1991
- Development of a monoclonal antibody-based detection system for pathogenic Listeria monocytogenes Scott A. J Food Microbiology. 8:325-330. 1991
- Expression of the transglutaminase gene in Escherichia coli. Journal of Biological Chemistry. 23:947-953. 1991
- Extending the shelf-life of cottage cheese: Identification of spoilage flora and their control using food grade preservatives . Amer. Cult. Dairy Prod. J. 26:8-12. 1991
- Identification of a nucleotide sequence conserved in Lactococcus lactis bacteriophages. Gene. 98:95-100. 1991
- Implications of biotechnology, risk assessment and communications for the safety of foods of animal origin. J. Amer. Vet. Med. Assoc. 199:1714-1721. 1991
- Irreversible denaturation of Lactobacillus bulgaricus b-galactosidase. Milchwissenschaft. 46:753-757. 1991
- Isolation of monoclonal antibodies that react preferentially with Listeria monocytogenes. Food Microbiology. 8:325-330. 1991
- Molecular characterization of a Lactococcus lactis bacteriophage F4-1. Food Microbiology. 8:15-26. 1991
- Molecular cloning and nucleotide sequence of the major capsid protein of Lactococcus lactis ssp. cremoris bacteriophage F4-1. Gene. 101:121-125. 1991
- Nucleotide sequence and deletion analysis of a gene coding for a structural protein of Lactococcus lactis bacteriophage F4-1. Food Microbiology. 8:27-32. 1991
- A simple procedure for the in vitro selection of oligonucleotide primed site-directed mutations. DNA Prot. Eng. Tech. 2:48-50. 1990
- An improved method for oligonucleotide mediated site-directed mutagenesis. Biotechniques. 9:555-556. 1990
- Cloning and sequencing of the genomic bovine β-lactoglobulin gene. Nucleic Acids Research. 18:3051. 1990
- Expression and secretion of thaumatin from Aspergillus oryzae. Agricultural and biological chemistry. 54:2513-2520. 1990
- Expression of recombinant bovine β-lactoglobulin in Escherichia coli. Agr. Biol. Chem. 54:949-955. 1990
- Identification of essential histidine residues in the active site of the Escherichia coli xylose (glucose) isomerase. Proceedings at the National Academy of Science USA. 87:618-622. 1990
- Purification and characterization of rat liver transglutaminase. Inter. J. Biochem. 22:53-59. 1990
- Thermal inducible expression of xylose isomerase and its performance in a hollow fiber bioreactor. Journal of Industrial Microbiology and Biotechnology. 4:1-5. 1989
- A simple and rapid method for the selection of oligonucleotide-directed mutants. Gene. 65:129-133. 1988
- Characterization of Lactobacillus bulgaricus bacteriophage ch2. Applied Environmental Microbiology. 54:1138-42. 1988
- Genetic transformation of an argB- strain of Aspergillus oryzae. Applied and Environmental Microbiology. 54:1610-1611. 1988
- Heterologous expression of the Escherichia coli β-galactosidase gene in Streptococcus lactis by translational fusion. Food Microbiology. 5:59-73. 1988
- Cloning and nucleotide sequence of the bovine β-lactoglobulin gene. Gene. 61:85-88. 1987
- Hyperexpression of Escherichia coli xylose isomerase. Biotechnol. Prog. 2:140-144. 1986
- Analysis of xylose operon regulation by Mud-lac fusion: Trans effect of plasmid coded xylose operon. Can. J. Microbiol. 31:930-933. 1985
- Association of lactase activity with conidiation in an aflatoxigenic strain of Aspergillus parasiticus. FEMS Letters. 27:277-280. 1985
- Evidence for a xylose metabolic pathway in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 28:549-543. 1985
- Expression of pAMβl tetracycline resistance in Corynebacterium glutamicum: Segregation of antibiotic resistance due to intramolecular recombination. Biotech. Lett. 7:717-722. 1985
- Genetic engineering of coryneform bacteria. Trends Biotechnology. 3:305-309. 1985
- Effect of volatile components of carrot seed oil in growth and aflatoxin production by Aspergillus parasiticus. Journal of Food Science. 48:762-764. 1983
- Asexual developmental markers in an aflatoxigenic strain of Aspergillus parasiticus. Can. J. Microbiol. 28:1206-1209. 1982
- Relationship of asexual development to aflatoxin production in Aspergillus parasiticus. Journal of Food Safety. 5:31-40. 1982
- Inhibition of aflatoxin production by carrot root extract. Journal of Food Science. 45:1210-1213. 1980
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chapter
- Integration of microfabrication and surface functionalization strategies for analysis of cell-surface interactions. Biomaterial and Biomedical Engineering. 2008
- Bionanofabrication: a tool for creating unique structures through in vitro polymer synthesis. Microbial Bionanotechnology: Biological self-assembly systems and biopolymer-based nanostructures. 35-64. 2006
- DNA based biosensors. Encyclopedia of Sensors. 2006
- Too small to see: educating the next generation in nanoscale science and engineering. Nanofabrication Towards Biomedical Applications: Techniques, Tools, Applications, and Impact. 2004
- Rapid methods for the detection of Listeria. Listeria, Listeriosis and Food Safety. 1999
- Genetic Engineering of Food Proteins. Food Proteins and their applications. 425-442. 1997
- Detection of Listeria monocytogenes by PCR coupled ligase chain reaction. PCR Strategies. 347-361. 1995
- Stress response in Lactococcus lactis. Genetics of the streptococci, enterococci, and lactococci. Dev. Biol. Stand. 449-454. 1995
- Detection of Listeria monocytogenes by PCR coupled ligase chain reaction (LCR). PCR Protocols. Academic Press. 347-361. 1994
- Ligase-mediated detection techniques. Methods in DNA Amplification. 83-92. 1994
- Ligasemediated detection techniques. Methods in DNA Amplification. 83-92. 1994
- Protein engineering studies of β- lactoglobulin. Biochemistry of Milk Products. Royal Society of Chemistry. 114-126. 1993
- Rapid methods for the detection of Listeria. Molecular approaches to improving food quality and safety. 189-204. 1992
- Biomass. Biotechnology: The science and the business. 1991
- Biotechnology and its implications for the future design and production of food ingredients. Bio and Food Engineering. 1990
- Development of a strain of Saccharomyces cerevisiae to utilize hemicellulosic biomass. Biotechnology for Energy. 1990
- Prokaryotic microorganisms. Biotechnology, Volume 7b-Gene Technology. 1989
- Single Cell Protein: Production, Modification and Utilization. Impact of Biotechnology on Food Production and Processing. 1985
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conference paper
- Too small to see. The Role of Lifelong Education in Nanoscience and Engineering. 2008
- A microchip-based DNA purification and real-time PCR biosensor for bacterial detection. Proceedings of The 3rd IEEE Conference on Sensors. 1191-1194. 2004
- Bionanofabrication of ordered nanoparticle arrays using prokaryotic S-layer proteins. Nanobiotechnology Center (NBTC) Annual Symposium. 2004
- Refractive Index-Based Detection of Biomolecular Interactions. SPIE Proceedings. 4206. 2001
- Molecular Epidemiologic Studies on Equine Motor Neuron Disease. Proceedings of the Seventh International Conference on Equine Infectious Diseases, Tokyo, Japan. 326-327. 1995
- Detection of Listeria monocytogenes in surface swabs using PCR-coupled ligase chain reaction. Proceedings of the 34th workshop of the German Veterinary Medical Society - Studygroup for Food Hygiene (Part I - Oral Presentations), Giessen, Germany. 114-122. 1994
- Equine Motor Neuron Disease: Molecular Epidemiology. The Kenya Veterinarian (Proceedings of the 7th International Symposium on Veterinary Epidemiology and Economics). 290-292. 1994
- The utility of nucleic acid-based assays in the detection of Listeria monocytogenes and in the epidemiologic tracking of isolates. Proceedings of "Conquering Listeria" - A Food Safety Symposium. 1993
- Design and modification of protein functionality. Proceedings of the International Bio Symposium 90 Nagoya. 69-73. 1990
- The use of recombinant DNA techniques to improve lactic acid starter cultures. Proceedings of BioExpo 86. 151-170. 1986
- Current status of Genetic Engineering of Lactobacillus. Symp UNIDO. 26-29. 1984
-
document part
- Biologically Inspired Nanostructures: Optimization of catalyst particle binding to bacterial S-layers for bio-templated growth of highly ordered semiconductor nanowire/nanotube arrays 2002
- A non-isotopic PCR-coupled LCR reaction assay for the identification of Erwinia stewartii. 549. 1994
- Evaluation of a non-isotopic PCR-coupled ligase chain reaction assay for specificity to Erwinia stewartii. 1087. 1994
- Development of a ligase chain reaction assay for identification of Erwinia stewartii. 365. 1993
-
manual
- Ligase chain reaction. 631-652. 1995
- Ligase chain reaction. 631-652. 1995
-
report
- Dairy products 2009
- Bacillus cereus 1999
- Escherichia coli 1999
- Kluyveromyces 1999
- Lactobacillus 1999
- Lactococcus 1999
- Listeria 1999
- Food Microbiology 1997
- Asexual development in an aflatoxigenic strain of Aspergillus parasiticus 1981
featured in archived article
- CNF, cancer institute to host cancer research workshop
- Cornell's cancer vaccine for ovarian cancer and melanoma begins clinical trials
- Disney's Epcot opens third Cornell-developed nanotechnology exhibit
- Gold nanoparticles are used to target cancer
- New student team aims to create biomachines that destroy pollutants, cancer cells
- Onondaga Nation students get hands-on dairy tour
- Portable device detects anthrax in under an hour
speaker at Cornell event
Teaching
teaching overview
- Microorganisms play a central role in a variety of food, agricultural, and environmental processes. A comprehensive survey of the roles that microorganisms play in industrial/biotechnological processes as well as their importance in the safety and production of foods.
teaching activities
- ECE-6931: Master of Engineering Design Project II - Spring 2013
- ECE-7920: Thesis Research - Spring 2013
- ENGRG-4920: Undergraduate Research in Nanoscale Science and Engineering - Spring 2013
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Spring 2013
- FDSC-6960: Graduate Internship in Food Science - Spring 2013
- FDSC-6980: Graduate Teaching Experience - Spring 2013
- FDSC-8900: Master's Level Thesis Research - Spring 2013
- FDSC-9900: Doctoral-Level Thesis Research - Spring 2013
- BIOMI-3940: Applied and Food Microbiology - Fall 2012
- ECE-7910: Thesis Research - Fall 2012
- ENGRG-4910: Undergraduate Research in Nanoscale Science and Engineering - Fall 2012
- FDSC-3940: Applied and Food Microbiology - Fall 2012
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Fall 2012
- FDSC-6960: Graduate Internship in Food Science - Fall 2012
- FDSC-6970: Graduate Individual Study in Food Science - Fall 2012
- FDSC-6980: Graduate Teaching Experience - Fall 2012
- FDSC-8900: Master's Level Thesis Research - Fall 2012
- FDSC-9900: Doctoral-Level Thesis Research - Fall 2012
- ECE-6931: Master of Engineering Design Project II - Spring 2012
- ECE-7920: Thesis Research - Spring 2012
- ENGRG-4920: Undergraduate Research in Nanoscale Science and Engineering - Spring 2012
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Spring 2012
- FDSC-6960: Graduate Internship in Food Science - Spring 2012
- FDSC-6980: Graduate Teaching Experience - Spring 2012
- FDSC-8900: Master's Level Thesis Research - Spring 2012
- FDSC-9900: Doctoral-Level Thesis Research - Spring 2012
- BIOMI-3940: Applied and Food Microbiology - Fall 2011
- ECE-7910: Thesis Research - Fall 2011
- ENGRG-4910: Undergraduate Research in Nanoscale Science and Engineering - Fall 2011
- FDSC-3940: Applied and Food Microbiology - Fall 2011
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Fall 2011
- FDSC-6960: Graduate Internship in Food Science - Fall 2011
- FDSC-6970: Graduate Individual Study in Food Science - Fall 2011
- FDSC-6980: Graduate Teaching Experience - Fall 2011
- FDSC-8900: Masters-Level Thesis Research - Fall 2011
- FDSC-9900: Doctoral-Level Thesis Research - Fall 2011
Service
service to the profession
- Chief-Editor, Encyclopedia of Food Microbiology Chief Editor 2009 -
- Earth & Sky Radio Series Advisor 2005 -
- NIH SBIR Biodefense Bacterial Agents Panel Research Review Panel 2004 -
- American Type Culture Collection Bacteriology Advisory Board 2000 -
- Research & Technology Directorate, US Department of the Army Board of Advisors 2000 -
- Business Innovation Center Committee Member 1998 -
- American Society for Microbiology
- Wiley Encyclopedia of Chemical Biology Editorial Advisory Board 2007 - 2009
- NCI Centers of Cancer Nanotechnology Excellence (CCNEs) Panel Research Review Panel 2005
- NIH-NIAID SBIR Infectious Diseases and Microbiology Panel Research Review Panel 2004
- Central New York Institute of Food Technologists Chairperson 1988 - 1989
Background
education and training
- Ph.D. in, Rutgers University 1981
- M.S. in, Rutgers University 1979
- B.S. in, Kansas State University 1975
awards and honors
- CALS Award for Promoting Multicultural Diversity, 2008
- Kaplan Family Distinguished Faculty Fellowship in Service-Learning, 2003
- Faculty Fellows in Service, 2001
- Liberty Hyde Bailey Professor, 2000
- Teaching Excellence Award, 1997
- Samuel Cote Prescott Award, 1990
- Yoplait Institute Research Award, 1988
Other
college
- CALS
research keyword
- Anti-cancer
- Cancer Research
- Protein
name prefix
- Professor