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Mezey, Jason G.
Cornell Faculty Member
Positions
- Associate Professor, Biological Statistics and Computational Biology (BSCB), College of Agriculture and Life Sciences (CALS)
I am a statistical geneticist working in the area of quantitative genetics, i.e. the genetics of complex phenotypes. I work in two areas within this subject: 1. development of statistical tools for identifying genes responsible for variation in complex phenotypes such as diseases and for modeling developmental pathways, 2. experimental quantitative analysis of developmental genetic pathways using Drosophila as a model system. Research in my group addresses questions in a number of fields: genomics, genetic medicine, veterinary sciences, plant sciences, Drosophila genetics, theoretical and statistical quantitative genetics, and evolutionary-developmental biology.
Research Areas
Websites
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- Publications
- Teaching
- Service
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Affiliations
other Cornell affiliations
Research
research overview
- My primary research focus is understanding the genetics, development, and evolution of characteristics with a complex genetic basis. Current research in my group can be divided into three main areas: 1. Statistical and computational approaches for finding genes underlying complex disease and quantitative phentoypes. 2. Modeling genetic networks and developmental pathways. 3. Quantitative genetics and evolution of Drosophila.
research activities
principal investigator on
co-principal investigator on
- GEPR: THE GENETIC BASIS OF TRANSGRESSIVE VARIATION IN RICE awarded by DIRECTORATE FOR BIOLOGICAL SCIENCES NSF 2010 - 2014
- IMPACT OF BDNF GENOTYPE AND STRESS ON LEARNING AND BRAIN DEVELOPMENT awarded by NATL INST OF MENTAL HEALTH, NIH 2008 - 2013
- PHD FELLOWSHIPS TO TRAIN PLANT BREEDERS FOR THE 21ST CENTURY awarded by NATIONAL INSTITUTE OF FOOD AND AGRICULTURE-USDA 2012 - 2017
- TOOLS FOR GENETIC AND GENOMIC STUDIES IN THE DOG awarded by NATL INST OF GENERAL MEDICAL SCIENCES, NIH 2008 - 2013
area(s) of concentration/expertise
keywords
- Quantitative genetics/genomics
- computational biology
- molecular evolution
- pathway modeling
- statistical genetics
submitted impact statement
Publications
individual publications
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academic article
- Four Loci Explain 83% of Size Variation in the Horse . PLoS One. 7. 2012
- Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa. Nature Communications. 2. 2011
- Biologic categorization of healthy nonsmokers, healthy smokers and smokers with COPD based on the transcriptome of the small airway epithelium. PLoS One. 6. 2011
- Genome-wide association mapping reveals rich genetic architecture of complex traits in Oryza sativa. Nature Communications. 2:467. 2011
- A genome-wide linkage scan in German shepherd dogs localizes canine platelet procoagulant deficiency (Scott Syndrome) to canine chromosome 27. Gene. 450:70-75. 2010
- A variational Bayes algorithm for fast and ac- curate multiple locus genome-wide association analysis. BMC Bioinformatics. 11:58. 2010
- Bayesian linkage analysis of categorical traits for arbitrary pedigree designs. PLoS One. 5. 2010
- Cocaine analog conjugated to disrupted E1-E3- adenovirus - a small molecule / viral protein vaccine strategy to evoke high-titer immunity against non-immunogenic addictive drugs.. Molecular Therapy. . 2010
- Gene expression network reconstruction by convex feature se- lection while incorporating genetic perturbations. PLoS Computational Biology. 6. 2010
- The trachea epithelium as a canary for cigarette smoking-induced bio- logic phenotype of the small airway epithelium. Clinical and Translational Science. 2:260-272. 2010
- Threshold of biologic response of the small airway ep- ithelium to low levels to tobacco smoke.. American Journal of Respiratory and Critical Care Medicine. 182:1524-1532. 2010
- Whole Genome SNP Association in the Horse: Identification of a Deletion in Myosin Va Responsible for Lavender Foal Syndrome. PLoS Genetics. 6. 2010
- Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development . Neuroscience. 164:108-120. 2009
- Coordinate control of expression of Nrf2-modulated genes in the human small airway epithelium highly responsive to cigarette smoking.. Molecular Medicine. 15:203-219. 2009
- Development and use of DNA archives at veterinary teaching hospital to investigate the genetic basis of disease. Journal of the American Veterinary Medical Association. 234:75-80. 2009
- Evolutionary co-expression domains in the Drosophila transcriptome. BMC Evolutionary Biology. 8:2. 2008
- Adaptive gene expression divergence inferred from molecular population genomics. PLOS Genetics. 3:2007-2013. 2007
- Quantitative trait loci for the circadian clock in Neurospora crassa. Genetics. 177:2335-2347. 2007
- Developmental regulation of skull morphology II: ontogenetic dynamics of covariance. Evolution and Development. 8:46-60. 2006
- Evolutionary genomics: codon bias and selection on single genomes. Nature. 433. 2005
- Naturally segregating QTL affecting wing shape of Drosophila melanogaster. Genetics. 169:2101-2113. 2005
- Automated measurement of Drosophila wings. BMC Evolutionary Biology. 3:25. 2003
- Comparing G matrices: why common principal components are informative. Genetics. 165:411-425. 2003
- Interpretation of the results of partial common principal components. Evolution. 56:433-440. 2003
- Hox cluster duplication in the horn shark (Heterodontus francisi) and the vertebrate radiation. Proceedings at the National Academy of Science USA. 97:1655-1660. 2000
- Is the genotype-phenotype map modular? An approach using quantitative trait locus (QTL) data. Genetics. 156:305-311. 2000
- Modeling the evolution of genetic architecture: a continuum of alleles model with pairwise AxA epistasis. Journal of Theoretical Biology. 203:163-175. 2000
- The test distribution of modularity statistics: a correction and clarification. Genetics. 158:31381. 2000
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chapter
- Modularity. Evolutionary Genetics: Concepts and Case Studies. 2006
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conference paper
- An effect of scale in a non-additive genetic model. Unifying Themes in Complex Systems: Proceedings of the First International Con-. 2000
presentations
featured in archived article
Teaching
teaching overview
- I teach a yearly four credit course in Quantitative Genomics and Genetics and a topics course in this same area. A description of the four credit course follows: A rigorous treatment of analysis techniques used to understand complex genetic systems. This course will cover both the fundamentals and advances in statistical methodology used to analyze disease, agriculturally relevant, and evolutionarily important phenotypes. Analysis techniques will include association mapping, interval mapping, and analysis of pedigrees for both single and multiple QTL models. Application of classic inference and Bayesian analysis approaches will be covered and there will be an emphasis on computational methods. I teach an annual seminar course on Quantitative Genomics aimed at graduate students where we discuss current journal articles and advances in the field. This past semester, I was one of four people contributing to a team-taught Bioinformatics course.
teaching activities
- BTRY-6970: Individual Graduate Study in Biometry and Statistics - Spring 2013
- BTRY-7900: Graduate-Level Dissertation Research - Spring 2013
- BTRY-7980: Graduate Supervised Teaching - Spring 2013
- BTRY-8900: Master's Level Thesis Research - Spring 2013
- BTRY-9900: Doctoral-Level Dissertation Research - Spring 2013
- BTRY-4830: Quantitative Genomics and Genetics - Fall 2012
- BTRY-6830: Quantitative Genomics and Genetics - Fall 2012
- BTRY-6970: Individual Graduate Study in Biometry and Statistics - Fall 2012
- BTRY-7900: Graduate-Level Dissertation Research - Fall 2012
- BTRY-7980: Graduate Supervised Teaching - Fall 2012
- BTRY-8900: Master's Level Thesis Research - Fall 2012
- BTRY-9900: Doctoral-Level Dissertation Research - Fall 2012
- BTRY-6970: Individual Graduate Study in Biometry and Statistics - Spring 2012
- BTRY-7900: Graduate-Level Dissertation Research - Spring 2012
- BTRY-7980: Graduate Supervised Teaching - Spring 2012
- BTRY-8900: Master's Level Thesis Research - Spring 2012
- BTRY-9900: Doctoral-Level Dissertation Research - Spring 2012
- BTRY-6700: Applied Bioinformatics and Systems Biology - Fall 2011
- BTRY-6970: Individual Graduate Study in Biometry and Statistics - Fall 2011
- BTRY-7210: Topics in Quantitative Genomics - Fall 2011
- BTRY-7900: Graduate-Level Dissertation Research - Fall 2011
- BTRY-7980: Graduate Supervised Teaching - Fall 2011
- BTRY-8900: Master's-Level Thesis Research - Fall 2011
- BTRY-9900: Doctoral-Level Dissertation Research - Fall 2011
Service
outreach overview
- My outreach focus includes providing quantitative genomic research opportunities for high school students and developing modules for quantitative genomic education that can be presented at the high school level. For the former of these, we have had a high school student working in my lab as part of the Ithaca based Learning Web program. For the latter, I have presented at the Cornell Institute for Biology Teachers workshop.
service to the profession
- National Institute of Health Committee Member 2008
reviewer or editor for
Background
education and training
- Ph.D. in Ecology and Evolutionary Biology, Yale University 2000
- B.A. in Biology, University of Pennsylvania 1994
awards and honors
Other
college
- CALS
research keyword
- Quantitative genetics/genomics
- computational biology
- molecular evolution
- pathway modeling
- statistical genetics
name prefix
- Dr.