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Gu, Zhenglong
Cornell Faculty Member
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Positions
- Associate Professor, Division of Nutritional Sciences (DNS), College of Agriculture and Life Sciences (CALS)
- Overview
- Affiliations
- Research
- Publications
- Teaching
- Service
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Overview
Affiliations
administrative responsibilities
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Division Safety Committee 2006-
Field seminar committee 2007-2010
member of graduate field
other Cornell affiliations
Research
principal investigator on
- GENETIC AND EVOLUTIONARY BASIS OF FUNGAL DRUG RESISTANCE awarded by NATL INST OF ALLERGY & INFECTIOUS DISEASE NIH 2010 - 2015
- POPULATION DIVERGENCE OF HUMAN METABOLIC GENES awarded by INTERNATIONAL LIFE SCIENCES INSTITUTE 2011 - 2013
submitted impact statement
Publications
individual publications
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academic article
- A mutation in intracellular loop 4 affects the drug-efflux activity of the yeast multidrug resistance ABC transporter Pdr5p.. PLoS One. 7. 2012
- Dynamic epistasis for the different alleles of the same gene. Proceedings of the National Academy of Sciences of the United States of America. 109:10420-10425. 2012
- Dynamic epistasis under varying environmental perturbations.. Proceedings of the National Academy of Sciences of the United States of America. 109:10420-10425. 2012
- Rewiring of post-transcriptional RNA regulons: Puf4p in fungi as an example,. Molecular Biology and Evolution. 29:2169-2176. 2012
- A Conserved Structural Determinant Located at the Interdomain Region of Mammalian IRE1α. Journal of Biological Chemistry. 286:30859-30866. 2011
- A Conserved Structural Determinant Located at the Interdomain Region of Mammalian Inositol-requiring Enzyme 1α. Journal of Biological Chemistry. 286:30859-30866. 2011
- A highly-conserved structural “hinge” bridging the kinase and RNase domains of the IRE1 protein is critical for its stability and activation. Journal of Biological Chemistry. 286:30859-30866. 2011
- Genetic architecture of complex traits revealed by epistatic interaction. Genome Biology & Evolution. 3:909-914. 2011
- Growth of Novel Epistatic Interaction by Gene Duplication. Genome Biology & Evolution. 3:295-301. 2011
- Predominant gain of promoter TATA box after gene duplication associated with stress responses. Molecular Biology and Evolution. 28:2893-2904. 2011
- Antagonistic changes in sensitivity to antifungal drugs by functional loss of an important ABC transporter gene. PLoS One. 5. 2010
- Asynchronous regulation of backup circuits as a strategy for survival in the fluctuating environments. International Journal of Systems and Synthetic Biology. 1:227-239. 2010
- Detection of heterozygous mutations in the genome of mismatch repair defective diploid yeast using a Bayesian approach. Genetics. 186:493-503. 2010
- Genetic architecture of complex traits revealed by epistatic interaction. Genome Biology and Evolution. 3. 2010
- The Baker's Yeast Diploid Genome is Remarkably Stable in Vegetative Growth and Meiosis. PLoS Genetics. 6. 2010
- Tinkering evolution of a posttranscriptional RNA regulon by Puf3p in yeast. PLoS Genetics. 6. 2010
- Detecting positive selection in the budding yeast genome. Journal of Evolutionary Biology. 22:2430-2437. 2009
- Yeasts as models in evolutionary biology. Genome Biology. 10:304. 2009
- Functional relaxation of mitochondria after WGD in yeast. Genome Research. 18:1466-1471. 2008
- Genetic diversities detected by translational efficiency between Ashbya gossypii and yeasts. BMC Evolutionary Biology. 8:343. 2008
- Regulation dynamics of the WGD genes during the yeast metabolic oscillation. Molecular Biology and Evolution. 25:2513-2516. 2008
- Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789. Proceedings of the National Academy of Sciences USA. 104:12825-12830. 2007
- Rapid evolution in a pair of recent duplicate segments of rice. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 308:50-57. 2007
- Comparative analyses of gene expression evolution using functional genomic data. Molecular Biology and Evolution. 22:40-50. 2005
- Elevated evolutionary rates in the lab strain of S. cerevisiae. Proceedings of the National Academy of Sciences USA. 102:1092-1097. 2005
- Molecular mechanisms involved in robustness of yeast central metabolism against null mutations. Journal of Biochemistry. 137:177-187. 2005
- Duplicate genes increase expression diversity within and between species. Natural Genetics. 36:577-579. 2004
- Higher gene duplicabilities for metabolic proteins than for nonmetabolic proteins in yeast and E. coli. Journal of Molecular Evolution. 59:806-814. 2004
- Detection of gene duplications and block duplications in eukaryotic genomes. J Str. & Funct. Genom. 3:27-34. 2003
- Different evolutionary patterns between young duplicate genes in the human genome. Genome Biology. 4:R56. 2003
- Patterns of gene duplication in yeast and C. elegans. Journal of Molecular Evolution. 56:28-37. 2003
- Rate of evolution vs. fitness effect of gene deletion. Molecular Biology and Evolution. 20:772-774. 2003
- Role of duplicate genes in genetic robustness against null mutations. Nature. 421:63-66. 2003
- Extent of gene duplication in the genomes of drosophila, nematode, and yeast. Molecular Biology and Evolution. 19:256-262. 2002
- Rapid divergence in expression between duplicate genes inferred from microarray gene expression data. Trends Genetics. 18:609-613. 2002
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chapter
- Polymorphism: effect on nutrient utilization and metabolism. Modern Nutrition in Health and Diseases. 2012
Teaching
teaching activities
- NS-8990: Master's Thesis and Research - Spring 2013
- NS-9990: Doctoral Thesis and Research - Spring 2013
- NS-8990: Master's Thesis and Research - Fall 2012
- NS-9990: Doctoral Thesis and Research - Fall 2012
- NS-4130: Nutritional Genomics - Evolution and Environment - Spring 2012
- NS-8990: Master's Thesis and Research - Spring 2012
- NS-9990: Doctoral Thesis and Research - Spring 2012
- ANTHR-2750: Human Biology & Evolution - Fall 2011
- NS-2750: Human Biology & Evolution - Fall 2011
- NS-4000: Directed Readings - Fall 2011
- NS-8990: Master Thesis - Fall 2011
- NS-9990: Doctoral Thesis - Fall 2011
recent courses taught
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NS2750, Human Biology and Evolution
NS4130, Nutritional Genomics-Evolution and Environment
NS7030 Seminar Nutritional Science
BIOG 4990, Independent Undergraduate Research
NS 4010, Empirical Research (Independent Study)
Service
current professional activities
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Genomics (minor field), 2009-present
Genetics & Development, 2008- present
Computational Biology, 2008-present
Nutritional Sciences, 2006-present
service to the profession
- Kunming Institute of Zoology, Chinese Academy of Science Program Organizer 2012 -
event host
Background
education and training
- Ph.D. in Ecology & Evolution, University of Chicago 2003
- Ph.D. in Ecology & Evolution, University of Chicago 2003
- B.S. in Biochemistry and Molecular Biology, Peking University 1998
- B.S. in Biochemistry and Molecular Biology, Peking University 1998
Other
college
- CALS
name prefix
- Dr.