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Clark, Andrew G.
Jacob Gould Schurman Professor of Population Genetics
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Positions
- Professor, Molecular Biology and Genetics (MBG), College of Agriculture and Life Sciences (CALS)
- Professor, Ecology and Evolutionary Biology (EEB), College of Agriculture and Life Sciences (CALS)
- Professor, Biological Statistics and Computational Biology (BSCB), College of Agriculture and Life Sciences (CALS)
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Affiliations
member of graduate field
other Cornell affiliations
advisory group member
Research
principal investigator on
- BUILDING ON GWAS FOR NHLBI-DISEASES: THE CHARGE CONSORTIUM: ARRA awarded by NATL INST OF HEALTH DHHS 2009 - 2012
- DROSOPHILA GENES CAUSING MALE X FEMALE INTERACTION IN REPRODUCTION awarded by NATL INST OF CHILD HEALTH & HUMAN DEVELOPMENT, NIH 2012 - 2017
- DROSOPHILA GENES CAUSING MALE X FEMALE INTERACTION IN REPRODUCTION: ARRA awarded by NATL INST OF HEALTH DHHS 2009 - 2012
- FUNCTIONAL AND COMPARATIVE GENOMICS OF DROSOPHILA IMMUNITY awarded by NATL INST OF HEALTH DHHS 2012 - 2017
- GENETIC ANALYSIS OF MALE X FEMALE INTERACTION IN MALE DROSOPHILA SPERM COMPETITION awarded by NATL INST OF HEALTH DHHS 2010 - 2012
- GENOMIC APPROACHES TO COMMON CHRONIC DISEASE awarded by NATL INST OF GENERAL MEDICAL SCIENCES, NIH 2011 - 2013
- IMPACT OF BDNF GENOTYPE AND STRESS ON LEARNING AND BRAIN DEVELOPMENT awarded by NATL INST OF MENTAL HEALTH, NIH 2008 - 2013
- MODELING DNA DIVERSITY IN REVERSE CHOLESTEROL TRANSPORT awarded by NATL HEART LUNG & BLOOD INST, NIH 2008 - 2013
- POPULATION, STRUCTURE, ADMIXTURE, AND SELECTION ACROSS THE 1000 GENOMES DATA SET awarded by NATL INST OF HEALTH DHHS 2010 - 2013
- THE GENETICS AND GENOMICS OF SEX-RATIO MEIOTIC DRIVE IN DROSOPHILA AFFINIS awarded by NATL INST OF HEALTH DHHS 2012 - 2015
co-principal investigator on
- ACQUISITION OF ILLUMINA HISEQ 2500 awarded by OFFICE OF THE DIRECTOR NIH 2012 - 2013
- GENETIC TRANSMISSION OF COMPONENTS OF THE HUMAN GUT MICROBIOME awarded by NATL INST OF HEALTH DHHS 2011 - 2015
submitted impact statement
Publications
individual publications
-
academic article
- A large neurological component to genetic differences underlying female sperm preferences in Drosophila. Genetics. 193:177-85. 2013
- A general population genetic framework for antagonistic selection that accounts for demography and recurrent mutation.. Genetics. 190:1477-1489. 2012
- Disentangling the relationship between sex-biased gene expression and X-linkage.. Genome Research. 22:1255-1265. 2012
- Faster-x evolution of gene expression in Drosophila.. PLoS Genetics. 8. 2012
- Folate network genetic variation predicts cardiovascular disease risk in non-hispanic white males. Journal of Nutrition. 142:1272-1279. 2012
- Genetic Variation in Antioxidant Enzymes and Lung Function in the Health, Aging, and Body Composition Study. Free Radical Biology & Medicine. 52:1577-1583. 2012
- Genome sequencing reveals complex speciation in the Drosophila simulans clade.. Genome Research. 22:1499-1511. 2012
- Identification of avian W-linked contigs by short-read sequencing.. BMC Genomics. 13:9. 2012
- Impact of genetic architecture on the relative rates of X versus autosomal adaptive substitution. Molecular Biology and Evolution. 2012
- Impact of microRNA regulation on variation in human gene expression.. Genome Research. 2012
- Inferences of demography and selection in an African population of D. melanogaster.. Genetics. 193:215-228. 2012
- Mutation spectrum of Drosophila CNVs revealed by breakpoint sequencing.. Genome Biology. 13. 2012
- Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.. Science. 337:1658-1661. 2012
- Natural genetic variation in male reproductive genes contributes to nontransitivity of sperm competitive ability in Drosophila melanogaster.. Molecular Ecology. 2012
- Random X inactivation in the mule and horse placenta.. Genome Research. 22:1855-1863. 2012
- Recent explosive population growth has resulted in a large excess of rare variants in humans.. Science. 336:740-743. 2012
- The BDNF Val66Met polymorphism moderates early deprivation effects on attention problems.. Development and Psychopathology. 24:1215-1223. 2012
- The brain-derived neurotrophic factor VaI66Met polymorphism moderates early deprivation effects on attention problems.. Development and Psychopathology. 24:1215-1223. 2012
- A Survey for Novel Imprinted Genes in the Mouse Placenta by mRNA-seq. Genetics. 189:109-122. 2011
- A Survey for Novel Imprinted Genes in the Mouse Placenta by mRNA-seq. Genetics. 189:109-122. 2011
- Analyses of X-linked and autosomal genetic variation in population-scale whole genome sequencing.. Nature. 43:741-743. 2011
- Association between Sex-Biased Gene Expression and Mutations with Sex-Specific Phenotypic Consequences in Drosophila. Genome Biology & Evolution. :151-155. 2011
- Associations between Variation in X Chromosome Male Reproductive Genes and Sperm Competitive Ability in Drosophila melanogaster.. International Journal of Evolutionary Biology. 2011. 2011
- Biologic categorization of healthy nonsmokers, healthy smokers and smokers with COPD based on the transcriptome of the small airway epithelium. PLoS One. 6. 2011
- Detecting directional selection in the presence of recent admixture in African Americans. Genetics. 187:823-835. 2011
- Drosophila duplication hotspots are associated with late-replicating regions of the genome. PLoS Genetics. 7:11. 2011
- Environmental and genetic perturbations reveal networks of metabolic regulation. Nature. 7:563:1-19. 2011
- Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster.. Molecular Ecology. :4098-4108. 2011
- Folate Network Genetic Variation, Plasma Homocysteine, and Global Genomic Methylation Content. BMC Medical Genetics. 12:150. 2011
- Genes involved in convergent evolution of eusociality in bees.. Proceedings at the National Academy of Science USA. 108:7472-7477. 2011
- Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection.. Genome Biology. 12. 2011
- The functional spectrum of low-frequency coding variation.. Genome Biology. 12:9. 2011
- The resolution of sexual antagonism by gene duplication.. Genetics. 187:919-937. 2011
- A Hierarchical Bayesian Model for a Novel Sparse Partial Diallel Crossing Design. Genetics. 185. 2010
- A map of human genome variation from population-scale sequencing. Nature. 467:1061-73. 2010
- Balancing selection maintains a form of ERAP2 tat undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genetics. 6. 2010
- Contrasting methods of quantifying fine structure of human recombination. Annual Review of Genomics and Human Genetics. 11. 2010
- Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nature Communications. 1. 2010
- Diversity of human copy number variation and multicopy genes. Science. 330. 2010
- Functional regulatory divergence of the innate immune system in interspecific Drosophila hybrids. Molecular Biology and Evolution. . 2010
- Gene Duplication, Gene Conversion, and the Evolution of the Y Chromosome. Genetics. 186. 2010
- Genetic interactions between the sexes mediate sperm competition in Drosophila: Sex Peptide × Sex Peptide Receptor. Genetics. 186:1355-65. 2010
- Genotype and gene expression associations with immune function in Drosophila. . PLoS Genetics. 6. 2010
- Inferring Genetic Ancestry: opportunities, challenges, and implications. American Journal of Human Genetics. 86. 2010
- Paternally biased X inactivation in mouse neonatal brain. Genome Biology. 11. 2010
- Population Genetic Structure of the People of Qatar. American Journal of Human Genetics. 87. 2010
- Population dynamics of PIWI-RNAs (piRNAs) and their targets in Drosophila. Genome Research. 20. 2010
- Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Genome Biology. 18. 2010
- The effect of recent admixture on inference of ancient human population history. Genetics. 185. 2010
- The genetic basis for male x female interactions underlying variation in reproductive phenotypes of Drosophila. Genetics. 186:1355-65. 2010
- The trachea epithelium as a canary for cigarette smoking-induced bio- logic phenotype of the small airway epithelium. Clinical and Translational Science. 2:260-272. 2010
- Translocation of Y-linked genes to the dot chromosome in D. pseudoobscura. Molecular Biology and Evolution. 27. 2010
- A case for sequencing the genome of the house fly, Musca domestica (Diptera: Muscidae) . J. Mol. Entomol. 46:175-182. 2009
- Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development . Neuroscience. 164:108-120. 2009
- Comparative profiling of the transcriptional response to infection in two species of Drosophila by short‐read cDNA sequencing. BMC Genomics. 10:259. 2009
- Darwinian and demographic forces affecting human protein coding genes. Genome Research. 19:838-849. 2009
- Disease-mediated inbreeding depression in a large, open population of cooperative crows. Proceedings of the Royal Society of London Series B. 276:2057-2064. 2009
- Estimation of fine-scale recombination intensity variation in the white-echinus interval of D. melanogaster. Journal of Molecular Evolution. 69:42-53. 2009
- Evolutionary processes acting on non‐coding DNA in humans inferred from patterns of polymorphism and divergence. PLoS Genetics . PLoS Genetics. 5. 2009
- Finding the Missing Heritability of Complex Diseases. Nature. 461:747-753. 2009
- Life after GWA Studies. Science. 326:239-240. 2009
- Methods for human demographic inference using haplotype patterns from genome‐wide SNP data. Genetics. 182:217-231. 2009
- Origin and Evolution of Y chromosomes: Drosophila tales. Trends Genet. 25:270-277. 2009
- Population dynamics of PIWI‐RNAs (piRNAs) and their targets in Drosophila. Genome Res. 20:212-27. 2009
- Reproductive partitioning and the assumptions of reproductive skew models in the cooperatively breeding American Crow. Animal Behavior. 77:503-512. 2009
- Strain-dependent differences in several reproductive traits are not accompanied by transcriptome changes in female Drosophila melanogaster. Genetics. 181:1273-80. 2009
- Strong Evidence for Lineage and Sequence Specificity of Substitution Rates and Patterns in Drosophila. Molecular Biology and Evolution. 26:1591-1605. 2009
- Targets of balancing selection in the human genome. Molecular Biology and Evolution. 26:2755-2764. 2009
- The unique role of selenocysteine in protein activity identified in vertebrate selenoproteomes. Molecular Biology and Evolution. 26:2031-2040. 2009
- X‐linked Variation in Immune Response in Drosophila melanogaste. Genetics. 10:1534. 2009
- A genome‐wide approach to identifying nove.‐imprinted genes. Human Genetics. 122:625-34. 2008
- APOE/C1/C4/C2 hepatic control region polymorphism influences plasma apoE and LDL cholesterol levels. Hum Mol Genet. 17:2039-2046. 2008
- Analysis of genetic variation in Ashkenazi Jews by high density SNP genotyping. BMC Genetics. 5:9-14. 2008
- Assessing the evolutionary impact of amino acid mutations in the human genome. PLoS Genetics. 4. 2008
- Contrasting the efficacy of selection on the X and autosomes in Drosophila. Molecular Biology and Evolution. 25:454-467. 2008
- Evolution of protein‐coding genes in Drosophila. Trends Genetics. 24:114-123. 2008
- Evolutionary constraint and adaptation in the metabolic network. Molecular Biology and Evolution. 25:2537-2546. 2008
- Genome‐wide association study provides evidence for a breast cancer risk locus at 6q22.33. Proceedings at the National Academy of Science USA. 105:4340-4345. 2008
- Genomic sequence from extinct relatives. Cell. 134:388-9. 2008
- Independent effects of cis‐ and trans‐regulatory variation on gene expression in Drosophila melanogaster. Genetics. 178:1831-1835. 2008
- Low conservation of gene content in the Drosophila Y chromosome. Nature. 456:949-951. 2008
- Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals. Genome Res. 18:1020-1029. 2008
- Post-mating gene expression profiles of female Drosophila melanogaster in response to time and to four male accessory gland proteins. Genetics. 179:1395-408. 2008
- Proportionally More Deleterious Variation in European than in African Populations. Nature. 451:994-997. 2008
- Regulatory changes underlying expression differences within and between Drosophila species. Natur. Genetics. 40:346-50. 2008
- The evolutionary costs of immunological maintenance and deployment. BMC Evolutionary Biology. 8:76. 2008
- Transcriptome‐wide identification of novel imprinted genes in neonatal mouse brain. PLoS One. 3. 2008
- Assessing the accuracy of statistical haplotype inference with sequence data of known phase. Genet. Epi. 31:659-671. 2007
- Associations between sperm competition and natural variation in male reproductive genes on the third chromosome of Drosophila melanogaster. Genetics. 176:1245-1260. 2007
- Conjuring SNPs to detect associations. Nat. Genetics. 39:815-816. 2007
- Contrasting infection strategies in generalist and specialist wasp parasitoids of Drosophila melanogaster. PLoS Pathogens. 3:1486-1501. 2007
- Dynamic evolution of the Drosophila innate immune system. Nature Genetics. 39:1461-1468. 2007
- Effects of the larval rearing environment on post-copulatory traits in Drosophila melanogaster. Biology Letters. 3:607-610. 2007
- Evolution of genes and genomes on the Drosophila phylogeny. Nature. 450:203-218. 2007
- Evolutionary Analysis of Amino Acid Repeats Across the Genomes of 12 Drosophila Species. Molecular Biology and Evolution. 24:2598-2609. 2007
- Evolutionary and biomedical insights from the rhesus macaque genome. Science. 316:222-234. 2007
- Full‐Exon Resequencing Reveals Toll‐like Receptor Variants Contribute to Human Susceptibility to Tuberculosis Disease. PLoS One. 2. 2007
- Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Molecular Biology of the Cell. 27:90-104. 2007
- Genomic analyses of transcription factor binding, histone acetylation, and gene expression reveal mechanistically distinct classes of estrogen-regulated promoters. Molecular and Cellular Biology. 27:5090-5104. 2007
- Heterogeneity in regional GC content and differential usage of codons and amino acids in GC‐poor and GC‐rich regions of the genome of Apis mellifera. Molecular Biology and Evolution. 24:611-619. 2007
- Localizing recent adaptive evolution in the human genome. PLoS Genetics. 3. 2007
- Recent and ongoing selection in the human genome. Nat Rev Genet.. 8:857-68. 2007
- Simple models of genomic variation in human SNP diversity. BMC Genomics. 8:146. 2007
- A Chip off the Old Block: A model for the evolution of genomic imprinting via selection for parental similarity. Genetics. 174:931-935. 2006
- Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. ATVB. 26:1828-36. 2006
- Contrasting multi‐site genotypic distributions among discordant quantitative phenotypes: the APOA1/C3/A4/A5 gene cluster and cardiovascular disease risk factors. Genet. Epi. 30:508-518. 2006
- Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster. Hum Hered. 61:87-96. 2006
- Extensive introgression of mitochondrial DNA in the absence of nuclear gene flow in the Drosophila yakuba subgroup. Evolution. 60:292-302. 2006
- Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria. Genetics. 174:1539-1554. 2006
- Genome‐based biomarkers for adverse drug effects, patient enrichment and prediction of drug response, and their incorporation into clinical trial design. Pers. Medicine. 3:177-185. 2006
- Genomics of the evolutionary process. Trends in Ecology and Evolution. 21:316-321. 2006
- Identification by full coverage array CGH of human DNA copy number increases relative to chimpanzee and gorilla. Genome Res. 16:173-181. 2006
- Insights into social insects from the genome of the honeybee Apis mellifera. Nature. 443:931-949. 2006
- Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster. Journal of Experimental Biology. 209:3837-3850. 2006
- Natural variation in male‐induced ‘cost‐of‐mating’ and allele‐specific association with male reproductive genes in Drosophila melanogaster. Philosophical Transactions of the Royal Society. 361:355-361. 2006
- Parent‐of‐origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting. Genetics. 173:1817-1821. 2006
- The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL‐C variability. Jour. Mol. Med. 84:561-572. 2006
- Thrice out of Africa: Ancient and modern expansions of the honey bee, Apis mellifera. Science. 314:642-645. 2006
- A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biology. 3. 2005
- APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study. Journal of Lipid Research. 46:564-571. 2005
- Ascertainment bias in studies of human genome-wide polymorphism. Genome Research. 15:1496-1502. 2005
- Associations between variation in second chromosome male reproductive proteins and sperm competitive ability in Drosophila melanogaster. Genetics. 169:243-257. 2005
- Comparative sequencing and analysis of Drosophila pseudoobscura. Genome Res. 15:1-18. 2005
- Compensatory cis‐trans evolution and the dysregulation of gene expression in interspecific hybrids of Drosophila. Genetics. 171:1813-1822. 2005
- Cross-species comparison of Drosophila male accessory gland protein genes. Genetics. 171:131-143. 2005
- Determinants of the success of whole genome association testing. Genome Res. 15:1463-1467. 2005
- Genome‐wide associations of gene expression variation in humans. PLoS Biology ePub. 1. 2005
- Genomic scans for selective sweeps using SNP data. Genome. 15:1566-75. 2005
- Harvesting medical information from our family tree. Science. 307:1052-1053. 2005
- Hotspots unglued. Nature Genetics. 37:563-564. 2005
- Mapping multiple quantitative trait loci by Bayesian classification. Genetics. 169:2305-2318. 2005
- Mining genetic epidemiology data with Bayesian networks II. Application to ApoE gene variation and plasma lipid levels. J Comput Biol. 12:1-11. 2005
- Natural Selection on Protein-Coding Genes in the Human Genome. Nature. 437:1153-7. 2005
- The Y chromosome of D. pseudoobscura is not homologous to the ancestral Drosophila Y. Science. 307:108-110. 2005
- The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern. Genome Res. 15:454-462. 2005
- Estrogen receptor genotypes and haplotypes associate with breast cancer. Cancer Res. 64:8891-8900. 2004
- Evidence for nonadditivity of single nucleotide polymorphism effects within the Apolipoprotein E gene. Ann Hum Genet. 68:521-535. 2004
- Evolutionary changes in cis and trans gene regulation. Nature. 430:85-88. 2004
- Extended linkage disequilibrium surrounding the hemoglobin E variant due to malarial selection. Am J Hum Genet. 74:1198-1208. 2004
- Genes regulated by mating, sperm or seminal proteins in mated female Drosophila melanogaster. Current Biology. 14:1509-1514. 2004
- Genetic basis of natural variation in D. melanogaster antibacterial immunity. Science. 303:1873-6. 2004
- Neuroendocrine control of larval ecdysis behavior in Drosophila: complex regulation by partially redundant neuropeptides. Journal of Neuroscience. 24:4283-4292. 2004
- Optimal haplotype block‐free selection of tagging SNPs for genome‐wide association studies. Genome Res. 14:1633-1640. 2004
- Reconstituting the frequency spectrum of ascertained SNP data. Genetics. 168:2373-2382. 2004
- Remating and sperm displacement in a natural population of Drosophila buzzatii inferred from mother‐offspring analysis of microsatellite loci. Journal of Evolutionary Biology. 17:376-381. 2004
- Specificity determinants and diversification of the Brassica self‐incompatibility pollen ligand. Proceedings at the National Academy of Science USA. 101:911-917. 2004
- The 6th international meeting on single nucleotide polymorphism and complex genome analysis. Pharmacogenomics. 5:153-156. 2004
- The effect of genetic conflict on genomic imprinting and modification of expression at a sex‐linked locus. Genetics. 166:565-579. 2004
- The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster. Human Genet. 115:36-56. 2004
- The role of haplotypes in candidate gene studies. Genet. Epid. 27:321-333. 2004
- Whole‐genome shotgun assembly and comparison of human genome assemblies. Proceedings at the National Academy of Science USA. 101:1916-1921. 2004
- A 3.9 cM resolution human SNP linkage map and screening set. Amer. J. Human Genet. 73:271-284. 2003
- A slippery boundary. Proceedings at the National Academy of Science USA. 100:4971-4972. 2003
- Bayesian sperm competition estimates. Genetics. 163:1193-1199. 2003
- Finding genes underlying risk of complex disease by linkage disequilibrium mapping. Curr. Op. Genet. Devel. 13:296-302. 2003
- Genome‐wide distribution of high frequency, completely mismatching SNP haplotype pairs observed to be common across human populations. Am. J. Hum. Genet. 73:1073-1081. 2003
- Inferring non‐neutral evolution from human‐chimp‐mouse orthologous gene trios. Science. 302:1960-1963. 2003
- Linkage disequilibrium and inference of population‐level recombination at 538 sites across the human genome. Amer. J. Human Genet. 73:285-300. 2003
- Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics. 165:623-635. 2003
- Molecular population genetics of genes encoding inducible antibacterial peptides in Drosophila melanogaster. Molecular Biology and Evolution. 20:914-23. 2003
- Natural selection shaped regional mitochondrial DNA variation in humans. Proceedings at the National Academy of Science USA. 100:171-176. 2003
- Natural variation in membrane transporter genes reveals evolutionary constraints. Proceedings at the National Academy of Science USA. 100:5896-5901. 2003
- Positive selection in the human genome inferred from human‐chimp‐mouse orthologous gene alignments. Cold Spr. Harbor Symp. Quant. Biol. 68:471-477. 2003
- Robustness of inference of haplotype block structure. Jour. Comp. Biol. 10:13-19. 2003
- Sequence diversity and haplotype structure in the human MDR1 gene. Pharmacogenetics. 13:481-494. 2003
- Tracing the Evolutionary History of Drosophila Regulatory Regions with Models that Identify Transcription Factor Binding Sites. Molecular Biology and Evolution. 20:703-714. 2003
- Y chromosome and other heterochromatic sequences of the Drosophila melanogaster genome: how far can we go? . Genetica. 117:227-237. 2003
- An introgression approach to mapping differences in mating success and sperm competitive ability in Drosophila simulans and D. sechellia. Genetic Research. 79:65-74. 2002
- Contributions of 18 additional DNA sequence variations in the gene coding for apolipoprotein E to explaining variation in quantitative measures of lipid metabolism. Am. J. Hum. Genet. 71:501-517. 2002
- Evolution of transcription factor binding sites in mammalian gene regulatory regions: conservation and turnover. Molecular Biology and Evolution. 19:1114-1121. 2002
- Genomes and evolution: Population genetics and molecular evolution of whole genomes. Curr Opin Genet Dev. 12:631-633. 2002
- Linkage disequilibrium and the mapping of complex human traits. Trends Genet. 18:19-24. 2002
- Malaria variorum. Nature. 418:283-285. 2002
- Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 12:395-405. 2002
- Sequence polymorphism at the human Apolipoprotein AII gene (APOA2): Unexpected deficit of variation in an African‐American sample. Human Genetics. 111:75-87. 2002
- Sperm competition and the maintenance of polymorphism. Heredity. 88:148-153. 2002
- The genome sequence of the malaria mosquito, Anopheles gambiae. Science. 298:129-149. 2002
- Transmissibility of field isolates of soybean viruses by Aphis glycines. Plant Disease. 86:1219-1222. 2002
- fRFLP and fAFLP: Medium-throughput genotyping by fluorescently post-labeling restriction digestion. Biotechniques. 33:539-46. 2002
- Differential selection after duplication in mammalian developmental genes. Molecular Biology and Evolution. 18:557-562. 2001
- Evidence for recurrent paralogous gene conversion and exceptional allelic divergence in the Attacin genes of Drosophila melanogaster. Genetics. 159:659-671. 2001
- Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila. Proceedings at the National Academy of Science USA. 98:7375-7379. 2001
- Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance. Science. 293:455-462. 2001
- Identification of five new genes on the Y chromosome of Drosophila melanogaster. Proceedings at the National Academy of Science USA. 98:13225-13230. 2001
- Local rates of recombination are positively correlated with GC content in the human genome. Molecular Biology and Evolution. 18:1139-1142. 2001
- Sequence Variation and Linkage Disequilibrium in the Human T‐cell receptor beta (TCRB) Locus. Am. J. Hum. Genet. 69:381-395. 2001
- Sexually antagonistic cytonuclear fitness interactions in Drosophila melanogaster. Genetics. 159:173-187. 2001
- The search for meaning in noncoding DNA. Genome Res. 11:1319-1320. 2001
- The sequence of the human genome. Science. 291:1304-1351. 2001
- Apolipoprotein E variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism. Am. J. Hum. Genet. 67:881-900. 2000
- Chromosomal effects on male and female components of sperm precedence in Drosophila. Genetics Research. 75:143-151. 2000
- Correlated effects of sperm competition and post‐mating female mortality. Proceedings at the National Academy of Science USA. 97:13162-13165. 2000
- Limits to prediction of phenotypes from knowledge of genotypes. Evol. Biol.. 32:205-224. 2000
- Microsatellite‐Alu haplotype variation at the PLAT locus. Am. J. Hum. Genet. 67:901-925. 2000
- Molecular population genetics of male accessory gland proteins in Drosophila. Genetics. 156:1879-1888. 2000
- Non‐Mendelian segregation of sex chromosomes in heterospecific Drosophila males. Genetics. 154:687-694. 2000
- Non‐transitivity of sperm precedence in Drosophila. Evolution. 54:1030-1035. 2000
- Protamine wars. Nature. 401:261-263. 2000
- Recombinational and mutational hotspots within the human lipoprotein lipase gene. Am. J. Hum. Genet. 66:69-83. 2000
- Seminal fluid causes temporarily reduced egg hatch in previously‐mated females. Proceedings of the Royal Society of London Series B. 267:201-203. 2000
- Sequence Diversity and Large‐scale Typing of SNPs in the Human Apolipoprotein E Gene. Genomic Research. 10:1532-1545. 2000
- Sequence Diversity and Large‐scale Typing of SNPs in the Human Apolipoprotein E Gene. Genomic Research. 10:1532-1545. 2000
- Y chromosomal fertility factors kl‐2 and kl‐3 of D. melanogaster encode dynein heavy chain polypeptides. Proceedings at the National Academy of Science USA. 97:13239-13244. 2000
- Chips for chimps. Nature Genetics. 22:119-120. 1999
- Estimating European admixture in an African‐Americans by using microsatellites and a microsatellitehaplotype (CD4/Alu). Hum. Genet. 104:149-157. 1999
- Female × male interactions in Drosophila sperm competition. Science. 283:217-220. 1999
- Genetic conflicts and the evolutionary origin of genomic imprinting. Trends in Ecology and Evolution. 14:197-201. 1999
- Intron size and natural selection. Nature. 401:344. 1999
- Selection for starvation resistance in Drosophila melanogaster: physiological correlates, enzyme activities and multiple stress responses. Journal of Evolutionary Biology. 12:370-379. 1999
- Sequence variation in the human angiotensin converting enzyme. Nature Genetics. 22:59-62. 1999
- The size distribution of homozygous segments in the human genome. Am. J. Hum. Genet. 65:1489-1492. 1999
- DNA sequence diversity in a 9.7 kb region of the human lipoprotein lipase gene. Natur. Genet. 19:233-240. 1998
- Different patterns of variation at the X‐ and Y‐linked microsatellite loci DXYS156X and DXYS156Y in human populations. Hum. Biol. 70:979-992. 1998
- Female genotypes affect sperm displacement in Drosophila. Genetics. 149:1487-1493. 1998
- Genetic conflicts, multiple paternity and the evolution of genomic imprinting. Genetics. 148:893-904. 1998
- Haplotype structure and population genetic inferences from nucleotide‐sequence variation in human lipoprotein lipase. Am. J. Hum. Genet. 63:595-612. 1998
- Inference of heterosis and epistasis in transposon‐tagged Drosophila. Crop Sci. Soc. Pub. 25:89-97. 1998
- Inference of sperm competition from broods of field‐caught Drosophila. Evolution. 52:1334-1341. 1998
- Mutation‐selection balance with multiple alleles. Genetica. 102:41-47. 1998
- Negative covariance suggests mutation bias in a two‐locus microsatellite system in the fish Sparus aurata. Genetics. 150:1567-1575. 1998
- Stress tolerance and metabolic response to stress in Drosophila melanogaster. Heredity. 81:514-527. 1998
- Comparisons of the nucleotide substitution process among repetitive segments of the alpha and beta spectrin genes. Journal of Molecular Evolution. 44:492-500. 1997
- Dynamics of linkage disequilibrium in bacterial genomes undergoing transformation and/or conjugation. Journal of Evolutionary Biology. 10:663-676. 1997
- Epistasis in measured genotypes: Drosophila P‐element insertions. Genetics. 147:157-163. 1997
- Intragenic duplication and divergence in the spectrin superfamily of proteins. Molecular Biology and Evolution. 14:1285-1295. 1997
- Molecular population genetics of Drosophila immune system genes. Genetics. 147:713-724. 1997
- Neutral behavior of shared polymorphism. Proceedings at the National Academy of Science USA. 94:7730-7734. 1997
- Polymorphism in genes that influence sperm displacement. Genetics. 144:401-408. 1996
- Population genetic aspects of gametophytic self‐incompatibility. Plant Species Biol. 11:13-22. 1996
- Constraints on intron evolution in the gene encoding the myosin alkali light chain in Drosophila. Genetics. 139:299-308. 1995
- Inference of population subdivision from the VNTR distributions of New Zealanders. Genetica. 96:37-49. 1995
- Length variation and secondary structure of introns in the Mlc1 gene in six species of Drosophila. Molecular Biology and Evolution. 13:471-482. 1995
- Microsatellite variation in North American populations of Drosophila melanogaster. Nucleic Acids Research. 23:3882-3886. 1995
- Physiological genetics of response to a high‐sucrose diet by Drosophila melanogaster. Biochem. Genet. 33:149-164. 1995
- Probing the evolution of senescence in Drosophila melanogaster with Pelement tagging. Genetica. 96:225-234. 1995
- P‐element‐induced variation in metabolic regulation in Drosophila. Genetics. 139:337-348. 1995
- Spontaneous mutation rate of modifiers of metabolism in Drosophila. Genetics. 139:767-779. 1995
- Variation in sperm displacement and its association with accessory gland protein loci in Drosophila melanogaster. Genetics. 139:189-201. 1995
- Comparative evolutionary analysis of metabolism in nine species of Drosophila. Evolution. 48:1230-1243. 1994
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- Conservation of alternative splicing and genomic organization of the myosin light chain (Mlc1) gene among Drosophila species. Molecular Biology and Evolution. 10:769-790. 1993
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- Mutation‐selection balance and metabolic control theory. Genetics. 129:909-923. 1991
- Population genetics of the Y chromosome of Drosophila melanogaster: rDNA variation and phenotypic correlates. Genetics Research. 58:7-13. 1991
- The structure of human mitochondrial DNA variation. Journal of Molecular Evolution. 33:543-555. 1991
- Direct and correlated responses to artificial selection on lipid and glycogen contents in Drosophila melanogaster. Genetical Research. 56:49-56. 1990
- Genetic components of variation in energy storage in Drosophila melanogaster. Evolution. 44:637-650. 1990
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- Rapid enzyme kinetic assays of individual Drosophila and comparisons of field‐caught Drosophila melanogaster and Drosophila simulans. Biochem. Genet. 27:263-278. 1989
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book
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booksection
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chapter
- Rapid evolution of innate immune response genes.. Rapidly Evolving Genes & Genetic Systems. 203-210. 2012
- Formal Genetics of Humans: Multifactorial Inheritance and Common Diseases. Human Genetics. 2009
- Trisomic phase inference. SNPs and Haplotype Inference, Lecture Notes in Bioinformatics. 1-8. 2004
- Methods for inferring block‐wise ancestral history from haploid sequences. Algorithms in Bioinformatics: lecture Notes in Computer Science. 44-59. 2002
- Estimating nucleotide divergence with RAPD data. Fingerprinting Methods Based on Arbitrarily Primed PCR. 219-226. 1997
- Stress and metabolic regulation in Drosophila. Environmental Stress, Adaptation and Evolution. 117-132. 1997
- Theory and Applications of RAPD‐PCR: Mispriming. Progress in Population Genetics and Human Evolution. 221-229. 1997
- A neutrality test for continuous characters based on levels of intraspecific variation and interspecific divergence. Non‐Neutral Evolution: Theories and Molecular Data. 101-111. 1994
- Self‐incompatibility: theoretical concepts and evolution. Genetic Control of Self‐Incompatibility and Reproductive Development in Flowering Plants. 220-242. 1994
- Evolutionary inferences from molecular characterization of self‐incompatibility alleles. Mechanisms of Molecular Evolution. 1992
- Enzymes and Adaptation. Genes in Ecology. 193-228. 1991
- Population structure and process in evolution. Population Biology: Ecological and Evolutionary Viewpoints. 1990
- Development of a stock‐progeny model for assessing power‐plant effects on fish populations. Assessing Power‐Plant Induced Mortality of Fish Populations. 196-226. 1977
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conference paper
- Inferences of modern human origins from variation in CD4 haplotypes. Proc. Trinational Workshop on Mol. Evol. 181-198. 1998
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document part
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review
presentations
featured in archived article
- Andrew Clark named the first Meinig Family Investigator in the Life Sciences
- Cornell launches Center for Comparative and Population Genomics
- Cornell part of national team to map 2,500 genomes
- DNA analysis for chimpanzees and humans reveals striking differences in genes for smell, metabolism and hearing
- Genetic divergence of man from chimp has aided human fertility but could have made us more prone to cancer, Cornell study finds
- In major advancement for medical research, Cornell scientists help analyze the rhesus macaque genome
Teaching
teaching activities
Service
service to the profession
- Alfred P. Sloan Foundation Committee Member 2012 -
- American Society of Human Genetics Committee Member 2012 -
- National Human Genetics Research Institute Board of Advisors 2006 - 2009
- Max Planck Institute for Evolutionary Anthropology Scientific Advisory Board Member 2000 - 2005
- National Science Foundation Population Biology Panel Member - 2003
- Society for Molecular Biology and Evolution President and President‐elect 1999 - 2002
- Genetics Society of America Member - 2001
- National Science Foundation Population Biology Panel Member - 2000
- National Science Foundation Population Biology Panel Member - 1998
- National Science Foundation Population Biology Panel Member 1992 - 1994
reviewer or editor for
Background
education and training
- B.S. in Biology and Applied Mathematics, Brown University 1976
awards and honors
- Elected to, 2012
- Fachbeirat Review Panel, 2011
- Advisory Council Member, 2009
- Jacob Gould Shurman Professor, 2008
- Meinig Professor, 2008
- Scientific Advisory Board Member, 2005
- Panel Member, 2003
- President & President-Elect, 2002
- Associate Editor, 2002
- Panel Member, 1998
- NIH Research Career Development Award, 1992
- Sloan Foundation Sabbatical Award, 1992
- NATO and Marshall Postdoctoral Fellowships
- Fellow
- Honorary Doctorate