Insecticide metabolism in insects involves only a few of nearly 100 cytochrome P450 isoforms CALS Impact Statement uri icon

abstract

  • In insects, cytochrome P450 monooxygenases (P450s) in the CYP6 family are important in the metabolism of insecticides. We created a strain lacking Cyp6d4 and determined its susceptibility to eight insecticides relative to two control strains. No obvious developmental abnormalities were seen in the mutant, indicating that Cyp6d4 is not critical for the regulation of vital endogenous compounds.