Networks
Co-Authors
Co-Investigators
Map Of Science
Stover, Patrick J.
Cornell Faculty Member
Close
Positions
- Professor, Division of Nutritional Sciences (DNS), College of Agriculture and Life Sciences (CALS)
- Academic Director, Division of Nutritional Sciences (DNS), College of Agriculture and Life Sciences (CALS)
- Affiliations
- Research
- Publications
- Teaching
- Service
- Background
- Other
- View All
Affiliations
administrative responsibilities
-
Director, Division of Nutritional Sciences
Director, United Nations University Food and Nutrition Programme for Social Development
member of graduate field
other Cornell affiliations
Research
principal investigator on
- AGREEMENT FOR SUPPORT OF MANDANA ARABI awarded by NEW YORK ACADEMY OF SCIENCES 2011
- GENE-NUTRIENT INTERACTIONS IN NEURAL TUBE DEFECTS awarded by NATL INST OF CHILD HEALTH & HUMAN DEVELOPMENT, NIH 2008 - 2013
- HOMEOSTATIC REGULATION OF FOLATE METABOLISM awarded by NATL INST OF DIABETES, DIGESTIVE & KIDNEY, NIH 2007 - 2012
- HOMEOSTATIC REGULATION OF FOLATE METABOLISM awarded by NATL INST OF DIABETES, DIGESTIVE & KIDNEY, NIH 2012 - 2017
- NUTRITION TRAINING awarded by NATL INST OF DIABETES, DIGESTIVE & KIDNEY, NIH 2012 - 2017
submitted impact statement
- Nutritional Genomics: Interactions of vitamins and other dietary components with human genes in health and disease
- Nutritional Genomics: Interactions of vitamins and other dietary components with human genes in health and disease
- Nutritional Genomics: Interactions of vitamins and other dietary components with human genes in health and disease
Publications
individual publications
-
academic article
- Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.. Journal of Nutrition. 143:1-5. 2013
- Competition between sumoylation and ubiquitylation of serine Hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus. Journal of Biological Chemistry. 287:4790-9. 2012
- Dietary folate but not choline modifies neural tube defect risk in Shmt1 knock-out mice. American Journal of Clinical Nutrition. 95:109-114. 2012
- Dietary folate but not choline modifies neural tube defect risk in Shmt1 knock-out mice. American Journal of Clinical Nutrition. 95:109-114. 2012
- Dietary folate but not choline modifies neural tube defect risk in Shmt1 knock-out mice.. American Journal of Clinical Nutrition. 95:109-114. 2012
- Folate network genetic variation predicts cardiovascular disease risk in non-hispanic white males. Journal of Nutrition. 142:1272-1279. 2012
- Biomarkers of folate status in the National Health and Nutrition Examination Survey (NHANES): a roundtable summary. American Journal of Clinical Nutrition. 94. 2011
- Folate Network Genetic Variation, Plasma Homocysteine, and Global Genomic Methylation Content. BMC Medical Genetics. 12:150. 2011
- Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proceedings at the National Academy of Science USA. 108:15163-15168. 2011
- Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. Proceedings of the National Academy of Sciences. 108:15163-15168. 2011
- Mthfd1 is a Modifier of Chemically-induced Intestinal Carcinogenesis. Carcinogenesis. 32:427-433. 2011
- Mthfd1 is a Modifier of Chemically-induced Intestinal Carcinogenesis. Carcinogenesis. 32:427-433. 2011
- Mthfs is an essential gene in mice and a component of the purinosome. Fronteirs in nutrigenomics. 2:36. 2011
- Mthfs is an essential gene in mice and a component of the purinosome. Frontiers in Genetics. 2:36. 2011
- Nuclear localization of the de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA. Journal of Biological Chemistry. 286:44015-44022. 2011
- Nuclear localization of the de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA. Journal of Biological Chemistry. 286:44015-44022. 2011
- Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies. Journal of Nutrigenetics and Nutrigenomics. 4:293-305. 2011
- Shmt1 Heterozygosity Impairs Folate-Dependent Thymidylate Synthesis Capacity and Modifies Risk of Apcmin-Mediated Intestinal Cancer Risk. Cancer Research. 71:2098-2107. 2011
- Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. American Journal of Clinical Nutrition. 93:789-798. 2011
- Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. American Journal of Clinical Nutrition. 93:789-798. 2011
- High Resolution Mapping and Positional Cloning of ENU-induced Mutations in the Rw region of Mouse Chromosome 5. BMC Genetics. 11. 2010
- No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study. European Journal of Clinical Nutrition. 64. 2010
- PhenX: An Interdisciplinary Toolkit for Genetics and Epidemiology. Current Opinion in Lipidology. 21. 2010
- Vitamin B12 and older adults. Current Opinion in Clinical Nutrition and Metabolic Care. 13:24-7. 2010
- 5,10-Methenyltetrahydrofolate Synthetase Activity is Increased in Tumors and Modifies the Efficacy of Antipurine LY309887. Archives of Biochemistry and Biophysics. 481:145-150. 2009
- A UV-Responsive Internal Ribosome Entry Site Enhances Cytoplasmic Serine hydroxymethyltransferase Expression for DNA Damage Repair . Journal of Biological Chemistry. 284:31097-31108. 2009
- Mechanism of the Internal Ribosome Entry Site-mediated Translation of Serine Hydroxymethyltransferase 1. Journal of Biological Chemistry. 284:31085-31096. 2009
- Mthfd1 is an Essential Gene in Mice and Alters Biomarkers of Impaired One-Carbon Metabolism. Journal of Biological Chemistry. 284:1533-1539. 2009
- SHMT1 and SHMT2 are Functionally Redundant in Nuclear de novo Thymidylate Biosynthesis. PLoS One. 4. 2009
- Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylene-tetrahydrofolate but is not essential in mice. Journal of Biological Chemistry. 283:25846-25853. 2008
- A Ferritin-responsive Internal Ribosome Entry Site Regulates Folate Metabolism. Journal of Biological Chemistry. 282:29927-29935. 2007
- Effect of Vitamin B6 Availability on Serine Hydroxymethyltransferase in MCF-7 Cells. Archives of Biochemistry and Biophysics. 462:21-27. 2007
- Evidence for SUMO-Dependent Nuclear Location of the Thymidylate Biosynthesis Pathway. Journal of Biological Chemistry. 282:17623-17631. 2007
- Inhibition of 5,10-Methenyltetrahydrofolate Synthetase. Archives of Biochemistry and Biophysics. 458:194-201. 2007
- SUMO-1 Modification of Thymidylate Synthase and Dihydrofolate Reductase. Clinical Chemistry and Laboratory Medicine. 45:1760-1763. 2007
- Methenyltetrahydrofolate Synthetase is a High-Affinity Catecholamine-Binding Protein. Archives of Biochemistry and Biophysics. 455:175-187. 2006
- Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in Men. Journal of Nutrition. 135:1989-1994. 2006
- Regulation of Folate-mediated One-carbon Metabolism by 10-formyltetrahydrofolate Dehydrogenase. Journal of Biological Chemistry. 281:18335-18342. 2006
- Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma. Journal of Biological Chemistry. 281:4215-4221. 2006
- Mimosine Regulates Serine Hydroxymethyltransferase Transcription by Chelating Zinc: Implications for Effects on DNA Replication. Journal of Biological Chemistry. 280:396-400. 2005
- Cloning, expression, and purification of 5,10-methenyltetrahydrofolate synthetase from Mus musculus. Protein Expression and Purification. 35:276-283. 2004
- Methenyltetrahydrofolate Synthetase Regulates Folate Turnover and Accumulation. Journal of Biological Chemistry. 278:29856-29862. 2003
- Pyridoxal Phosphate Inhibits Dynamic Subunit Interchange Among Cytoplasmic Serine Hydroxymethyltransferase Tetramers. Journal of Biological Chemistry. 278:10142-10149. 2003
- Bringing Individuality to Public Health Recommendations. Journal of Nutrition. 132. 2002
- Cytoplasmic Serine Hydroxymethyltransferase Mediates Competition between Folate-Dependent Deoxyribonucleotide and S-Adenosylmethionine Biosyntheses. Journal of Biological Chemistry. 277:38381-38390. 2002
- Molecular and Genetic Considerations for Long-Term Nutrition Interventions. Asia Pacific Journal of Clinical Nutrition. 11. 2002
- Heavy Chain Ferritin Enhances Cytoplasmic Serine Hydroxymethyltransferase Expression and De Novo Thymidine Biosynthesis. Journal of Biological Chemistry. 276:19855-19861. 2001
- Lack of Catalytic Activity of a Murine mRNA Cytoplasmic Serine Hydroxymethyltransferase Splice Variant: Evidence against Alternative Splicing as a Regulatory Mechanism. Biochemistry. 40:4932-4939. 2001
- Murine Cysteine Dioxygenase Gene: Structural Organization, Tissue-specific Expression and Promoter Identification. Gene. 277:153-161. 2001
- Relationship between Dopamine-Stimulated Phospholipid Methylation and Single-Carbon Folate Pathway. Journal of Neurochemistry. 78:788-796. 2001
- Cytoplasmic Serine Hydroxymethyltransferase is an mRNA Binding Protein. Biochemistry. 39:11523-11531. 2000
- Mimosine is a Cell-Specific Antagonist of Folate Metabolism. Journal of Biological Chemistry. 275:19268-19274. 2000
- Purification and Properties of a Folate Catabolizing Enzyme. Journal of Biological Chemistry. 275:35646-35655. 2000
- X-ray Structure of the Murine Cytoplasmic Serine Hydroxymethyltransferase Quinonoid Ternay Complex: Evidence for Asymmetric Obligate Dimer Pairs. Biochemistry. 39:13313-13323. 2000
- Molecular Cloning, Characterization and Alternative Splicing of the Human Cytoplasmic Serine Hydroxymethyltransferase Gene. Gene. 210:315-324. 1998
- Methenyltetrahydrofolate Synthetase Activity Regulates Homocysteine Remethylation in Human Neuroblastoma Cells. Journal of Biological Chemistry. 272:4729-4734. 1997
- Molecular Cloning, Characterization and Regulation of the Human Mitochondrial Serine Hydroxymethyltransferase . Journal of Biological Chemistry. 272:1842-1848. 1997
- Haploinsufficiency of Cytosolic Serine Hydroxymethyltransferase in the Smith-Magenis Syndrome. American Journal of Human Genetics. 57:1342-1350. 1995
- Primary Structure and Tetrahydropteroylglutamate Binding Site of Rabbit Liver Cytosolic 5,10-Methenyltetrahydrofolate Synthetase. Journal of Biological Chemistry. 269:18429-18433. 1994
- Diffraction Grade Crystals of E. coli Serine Hydroxymethyltransferase. Journal of Molecular Biology. 230:1094-1096. 1993
- Evidence that 5-Formyltetrahydro-pteroylglutamate has a Metabolic Role in One-Carbon Metabolism. Advances in Experimental Medicine and Biology. 338:679-686. 1993
- Folylpoly-γ-glutamate Synthetase. Advances in Experimental Medicine and Biology. 338:629-634. 1993
- Purification and Properties of 5,10-Methenyltetrahydrofolate Synthetase. Advances in Experimental Medicine and Biology. 338:723-726. 1993
- E. coli Serine Hydroxymethyltransferase: The Role of Histidine 228 in Determining Reaction Specificity. Journal of Biological Chemistry. 267:17697-17687. 1992
- Enzymatic Mechanism for the Hydrolysis of 5,10-Methenyltetrahydropteroylglutamate to 5-Formyltetrahydropteroylglutamate by Serine Hydroxymethyltransferase. Biochemistry. 31:2155-2164. 1992
- Evidence for the Accumulation of a Stable Intermediate in the Non-Enzymatic Hydrolysis of 5,10-Methenyltetrahydropteroylglutamate to 5-Fomyl-tetrahydropteroylglutamate. Biochemistry. 31:2148-2155. 1992
- Synthesis of (6S)-5-Formyltetrahydropteroyl-polyglutamates and Interconversion to Other Reduced Pteroylpolyglutamate Derivatives. Analytical Biochemistry. 202:82-88. 1992
- 5-Formyltetrahydrofolate Polyglutamates are Slow, Tight-Binding Inhibitors of Serine Hydroxymethyltransferase. Journal of Biological Chemistry. 266:1543-1550. 1991
- Serine Hydroxymethyltransferase Catalyzes the Hydrolysis of 5,10-Methenyltetrahydrofolate to 5-Formyltetrahydrofolate. Journal of Biological Chemistry. 265:14227-14233. 1990
-
book
-
booksection
- The Gastrointestinal Tract in Health and Disease. Vol. 3. 2008
- Regulation of Folate Metabolism by Iron 2002
- Fat. Vol. 1. 2001
- Folic Acid. Vol. 1. 2001
- Iron. Vol. 2. 2001
- Nutrient Regulation of Gene Expression. Vol. 2. 2001
- Nutritional Biochemistry. Vol. 2. 2001
-
chapter
- Folic Acid. Modern Nutrition in Health and Disease. 2012
- Polymorphism: effect on nutrient utilization and metabolism. Modern Nutrition in Health and Diseases. 2012
- Folate in Human Nutrition . Vitamins and Vitamin-Like Nutrients for Prevention of Human Diseases. 91-100. 2011
- Folate, Vitamin B12 and Vitamin B6 . Nutrition in Epigenetics. 211-223. 2011
- One-Carbon Metabolism. Folate Health and Disease. 49-74. 2009
- The Roles of Sumo in Metabolic Regulation. SUMO Regulation of Cellular Processes. 137-153. 2009
- Nutritional Genomics . Clinical Medicine. 2008
- Ferritin and Serine Hydroxymethyltransferase. Nutrient and Gene Interactions in Cancer. 2005
- Polymorphisms: Effect of Nutrient Utilization and Metabolism. Modern Nutrition in Health and Disease. 2004
-
conference paper
- Regulation of the 5-Formyltetrahydrofolate Futile Cycle and Purine Biosynthesis by Methenyltetrahydrofolate Synthetase . The Proceedings of the 13th International Symposium on Chemistry & Biology of Pteridines & Folates. 300-316. 2006
- Effects of Cellular Glycine Concentration on Human Cell Proliferation in Culture. Chemistry and Biology of Pteridines and Folates. 491-494. 2002
- Rapid Affinity Purification of the T-protein from Rabbit Liver. Chemistry and Biology of Pteridines and Folates. 485-490. 2002
- Mimosine's Action is pyridoxal-phosphate independent. Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins. 2000
- Comparison of the Human Mitochondrial and Cytoplasmic Serine Hydroxymethyltransferase Genes. Chemistry and Biology of Pteridines and Folates. 377-380. 1997
- Intracellular Glycine and 5-formyltetrahydrofolate Concentrations Influence the Distribution of Folate One-Carbon Forms in Human Cells. Chemistry and Biology of Pteridines and Folates. 381-384. 1997
- Role of the Serine Hydroxymethyltransferase Glycine Quininoid in Controlling One-Carbon Metabolism in Eucaryotic and Procaryotic Cells. Proceedings of the 8thInternational Symposium on Vitamin B6 and Carbonyl Catalysis. 341-344. 1991
- Folic acid and neural tube defects: Are we any closer to understanding mechanisms? 2012
- Vitamin B12 and older adults 2010
- Insights into Metabolic Mechanisms underlying Folate-responsive Neural Tube Defects – A minireview 2009
- One-Carbon Metabolism-Genome Interactions in Folate-Associated Pathologies 2009
- Convergence of Genetic, Nutritional and Inflammatory Factors in Gastrointestinal Cancers 2008
- Discussion: Folate and vitamin B-12 metabolism: Overview and interaction with riboflavin, vitamin B-6, and polymorphisms 2008
- Folate-Mediated One-Carbon Metabolism 2008
- Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions 2008
- Folate-mediated One-carbon Metabolism and Neural Tube Defects - Balancing Genome Synthesis and Gene Expression 2007
- Human Nutrition and Genetic Variation 2007
- Influence of Human Genetic Variation on Nutritional Requirements 2006
- Nutrition and Developmental Biology: Implications for Public Health 2006
- Nutritional Genomics 2004
- Physiology of Folate Metabolism in Health and Disease 2004
- New Paradigms for Nutrient Regulation of Translation 2003
- The Role of Science in Identifying Common Ground in the GMO Debate 2003
- Nutrition and Developmental Biology 2002
- New Perspectives on Folate Catabolism 2001
- The Metabolic Role of Leucovorin 1993
presentations
featured in archived article
Teaching
teaching activities
- BIOMG-7940: Current Topics in Biochemistry - Spring 2013
- NS-6000: Special Problems for Graduate Students - Spring 2013
- NS-6200: Translational Research and Evidence-based Policy and Practice in Nutrition - Spring 2013
- NS-7040: Grant Writing - Spring 2013
- NS-8990: Master's Thesis and Research - Spring 2013
- NS-9990: Doctoral Thesis and Research - Spring 2013
- NS-3200: Introduction to Human Biochemistry - Fall 2012
- NS-6000: Special Problems for Graduate Students - Fall 2012
- NS-8990: Master's Thesis and Research - Fall 2012
- NS-9990: Doctoral Thesis and Research - Fall 2012
- NS-6000: Special Problems for Graduate Students - Spring 2012
- NS-6200: Translational Research and Evidence-based Policy and Practice in Nutrition - Spring 2012
- NS-7040: Grant Writing - Spring 2012
- NS-8990: Master's Thesis and Research - Spring 2012
- NS-9990: Doctoral Thesis and Research - Spring 2012
- NS-3200: Introduction to Human Biochemistry - Fall 2011
- NS-4000: Directed Readings - Fall 2011
- NS-6000: Special Problems for Grads - Fall 2011
- NS-8990: Master Thesis - Fall 2011
- NS-9990: Doctoral Thesis - Fall 2011
recent courses taught
-
Bio G 2000 - Research Apprenticeship
BioBM 4000 - Undergraduate Research
NS 3200 - Human Biochemistry
NS 4000 - Directed Readings
NS 4010 - Student Research
NS 4750 - Mechanisms Underlying Mammalian Developmental Defects
NS 6000 - Independent Study - Nutritional Genomics
NS 7040 - Grant Writing
Service
current professional activities
-
Director, Division of Nutritional Sciences
Director, United Nations University Food and Nutrition Programme for Social Development
Cornell University Graduate Field Membership: Nutrition, Biochemistry, Molecular and Cellular Biology
Member of the Food and Nutrition Board of the Institute of Medicine, National Academy of Sciences
Editorial Boards: Annual Review of Nutrition, The American Journal of Clinical Nutrition, The Journal of Biological Chemistry
service to the profession
- American Society for Nutrition Board Member 2011 -
- International Scientific Advisory Board, Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences Board of Advisors 2011 -
- American Society for Nutrition Reviews, Papers, and Guidelines Committee Committee Member 2009 -
- American Society for Nutrition Spokesperson 2008 -
- Food and Nutrition Board, Institute of Medicine, National Academies of Science Member 2007 -
- Food and Nutrition Board, Institute of Medicine, National Academies of Science Board Member 2007 -
- American Society for Nutritional Sciences Professional Society 1998 -
- American Association for the Advancement of Science Professional Society 1994 -
- American Society for Biochemistry and Molecular Biology Professional Society 1994 -
- Sigma-XI, Saint Joseph's University Chapter Professional Society 1985 -
- FASEB-sponsored conference: Engaging Basic Researchers in the Translational Research Enterprise. Steering committee member Committee Member - 2010
- American Society for Nutrition Spokesperson 2008 - 2009
- American Society for Nutrition Public Policy/Public Information Awards Committee Committee Member 2008 - 2009
- PhenX Consensus Measures for Phenotypes and Exposures. Chair, Nutrition and Dietary Supplements Committee. National Human Genome Research Institute (NIH) and RTI International Chairperson 2008 - 2009
- Public Policy and Communications Committee, American Society for Nutrition Chairperson 2007 - 2009
- Public Policy and Communications Committee, American Society for Nutrition Committee Member 2006 - 2009
- Food Science and Human Nutrition, Institute of Food and Agricultural Science, University of Florida Reviewer, Program - 2009
- The Association of Reproductive Health Professionals (ARHP). Member, expert advisory committee on Hot Topics in Preconception Care: Folate and Beyond Committee Member - 2009
- American Society for Nutrition Public Policy/Public Information Awards Committee Chairperson - 2008
- Nominations Committee, American Society for Nutrition Chairperson - 2007
- Living Well to 100 Conference Advisory Committee Committee Member - 2006
- Nutritional Genomics Conference Advisory Committee Committee Member - 2006
- Harmonization of Dietary Standards Expert Committee, United Nations University Committee Member - 2005
- Nutrigenomics Workshop Planning Committee, National Academy of Sciences, Institute of Medicine Committee Member - 2005
- International Homocysteine Meeting Advisory Committee Committee Member - 2005
- Living Well to 100 Conference Advisory Committee Committee Member - 2004
- Graduate Nutrition Education Committee, American Society for Nutritional Sciences Chairperson 2000 - 2003
- Graduate Nutrition Education Committee, American Society for Nutritional Sciences Committee Member 1999 - 2003
- Maternal Folate Supplementation expert committee, Food and Drug Administration Committee Member - 2003
- International Homocysteine Meeting Advisory Committee Committee Member - 2003
- Conrad Elvehjem Award Jury, American Society for Nutritional Sciences Committee Member - 2000
- AMERICAN CHEMICAL SOCIETY Professional Society 1994 - 1996
- Philadelphia Organic Chemists Club Professional Society 1984 - 1986
reviewer or editor for
- Canadian Cancer Society
- Health Research Council of New Zealand
- Integrative Nutrition and Metabolic Processes Study Section (INMP)
- NIH, CORBE Program Projects in Developmental Biology
- NIH, SBDD Study Section
- NIH, Special Study Section, Risk factors for Vascular Disease
- NIH/NCI Special Study Section RFA CA03-001 “Nutritional Modulation of Genetic Pathways Leading to Cancer”, U54 Program Projects
- NSERC/CRSNG
- The Journal of Biological Chemistry
Background
education and training
- Ph.D. in Biochemistry & Molecular Biophysics, Medical College of Virginia 1990
- B.S. in Chemistry, Saint Joseph's University 1986
awards and honors
- E.R.L. Stokstad Award in Nutritional Biochemistry, 1999
- Outstanding Educator, 1999
- Outstanding Educator, 1998
- Outstanding Educator, 1998
- Presidential Early Career Award for Scientists and Engineers, 1997
- Outstanding Alumnus Award, 1997
- Outstanding Educator, 1996
- Future Leader in Nutrition, 1996
- Young Scholar Travel Award for the 8th International Symposium on Vitamin B6 and Carbonyl Catalysis, Osaka, Japan, 1990
- John C. Forbes Research in Progress Award, First Place, 1990
- Reverend Joseph Molloy Award in Chemistry, 1986
Other
college
- CALS
name suffix
- PhD