administrative responsibilities
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Director of Graduate Studies, Genetics & Development
Member, University Faculty Local Advisory Council
Co-Chair, University Hearing Board
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Soloway, Paul D.
Cornell Faculty Member
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Area of expertise is mouse molecular genetics with a focus on mechanisms controlling placement of epigenetic modifications including DNA and histone methylation in the mouse genome. Additional areas of research include studies in nutritional genomics, specifically, identification of regions of the genome controlling if and how diet affects colorectal cancer.
Research Areas
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Affiliations
member of graduate field
other Cornell affiliations
Research
research activities
principal investigator on
- EPIGENETIC CONTROL OF A RAS ACTIVATOR awarded by NATL CANCER INSTITUTE, NIH 2008 - 2012
- EPIGENOMIC ANALYSIS ON A NANOSCALE DEVICE awarded by NATL INST ON DRUG ABUSE, NIH 2008 - 2013
- TOOLS FOR SINGLE MOLECULE AND SINGLE CELL EPIGENOMIC ANALYSIS awarded by NATL INST OF HEALTH DHHS 2012 - 2015
submitted impact statement
Publications
individual publications
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academic article
- Coordinate regulation of DNA methylation and H3K27me3 in mouse embryonic stem cells.. PLoS One. 8. 2013
- Breed-Dependent Transcriptional Regulation of 5′-Untranslated GR (NR3C1) Exon 1 mRNA Variants in the Liver of Newborn Piglets. . PLoS One. 7. 2012
- Craighead, Real-time analysis and selection of methylated DNA by fluorescence-activated single molecule sorting in a nanofluidic channel.. Proceedings of the National Academy of Sciences of the United States of America. 109:8477-8482. 2012
- Microfluidic extraction, stretching and analysis of human chromosomal DNA from single cells.. Lab Chip. 12:4848-4854. 2012
- Sequences sufficient for programming imprinted germline DNA methylation defined.. PLoS One. 7. 2012
- A Survey for Novel Imprinted Genes in the Mouse Placenta by mRNA-seq. Genetics. 189:109-122. 2011
- A Survey for Novel Imprinted Genes in the Mouse Placenta by mRNA-seq. Genetics. 189:109-122. 2011
- Imprinted Rasgrf1 expression in neonatal mice affects olfactory learning and memory. Genes, Brain and Behavior. 10:392-403. 2011
- Methylation on the mind. Nature Neuroscience. 14:1494-1496. 2011
- Methylation on the mind. Nature Neuroscience. 14:1494-1496. 2011
- Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus. Science. 332:848-852. 2011
- Role for piRNAs and noncoding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.. Science. 332:848-852. 2011
- Sequences sufficient for reprogramming imprinted germ-line DNA methylation defined . PLoS One. 7. 2011
- A Non-Coding RNA Within the Rasgrf1 Locus in Mouse Is Imprinted and Regulated by Its Homologous Chromosome in Trans. PLoS One. 5. 2010
- Paternally biased X inactivation in mouse neonatal brain. Genome Biology. 11. 2010
- Single Molecule Epigenetic Analysis in a Nanofluidic Channel. Analytical Chemistry. 82. 2010
- Single Molecule Epigenetic Analysis in a Nanofluidic Channel. Analytical Chemistry. 82. 2010
- Successful Computational Prediction of Novel Imprinted Genes From Epigenomic Features. Molecular and Cellular Biology. 30. 2010
- TIMP2 Deficiency Accelerates Adverse Post-Myocardial Infarction Remodeling Because of Enhanced MT1-MMP Activity Despite Lack of MMP2 Activation. Circulation Research. 106:796-808. 2010
- Imprint switch mutations at Rasgrf1 support conflict hypothesis of imprinting and define a growth control mechanism upstream of IGF1. Mammalian Genome. 20:654-663. 2009
- Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine. Biological Psychiatry. 66:758-768. 2009
- Antagonism between DNA and H3K27 Methylation at the Imprinted Rasgrf1 Locus. PLoS Genetics. 4. 2008
- Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates myogenesis and beta 1 integrin expression in vitro. Exp Cell Res. 314:11-24. 2008
- Transcriptomeâwide identification of novel imprinted genes in neonatal mouse brain. PLoS One. 3. 2008
- Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL. Leukemia. 21:1239-48. 2007
- Gene nutrient interactions and evolution. Nutrition Reviews. 64. 2006
- Individual Timp deficiencies differentially impact pro-MMP-2 activation. Journal of Biological Chemistry. 281:10337-10346. 2006
- Involvement of tissue inhibition of metalloproteinases-1 in learning and memory in mice. Behavioral Brain Research. 173:191-198. 2006
- Paramutable Possibilities. Nature. 441:413-414. 2006
- Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. American Journal of Pathology. 169:2104-2116. 2006
- Regulation of imprinted DNA methylation. Cytogenetic and Genome Research. 113:112-129. 2006
- Timing and Sequence Requirements Defined for Embryonic Maintenance of Imprinted DNA Methylation at Rasgrf1. Molecular and Cellular Biology. 26:9564-9570. 2006
- Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism. Journal of Neurobiology. 66:1365-1377. 2006
- Tissue inhibitor of metalloproteinase-2 (TIMP-2)-deficient mice display motor deficits. Journal of Neurobiology. 66:82-94. 2006
- Astrocyte reactivity to Fas activation is attenuated in TIMP-1 deficient mice: an in vitro study. BMC Neuroscience. 6:68. 2005
- Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology. 41:857-867. 2005
- Prepulse inhibition and fear-potentiated startle are altered in tissue inhibitor of metalloproteinase-2 (TIMP-2) knockout mice. Brain Research. 105:81-89. 2005
- Rasgrf1 Imprinting is Regulated by a CTCF-dependent Methylation-Sensitive Enhancer Blocker. PLoS Genetics. 25:11184-11190. 2005
- Tissue Inhibitor of MP-1 Deficiency Amplifies Acute Lung Injury in Bleomycin Exposed Mice. American Journal of Respiratory Cell and Molecular Biology. 33. 2005
- Tissue inhibitor of metalloproteinase 1 regulates resistance to infection. Infection and Immunity. 73:661-665. 2005
- Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory. European Journal of Neuroscience. 22:2569-2578. 2005
- Differential Inhibition of MT3-MMP and MT1-MMP by TIMP-2 and TIMP-3 regulates Pro-MMP-2 activation. Journal of Biological Chemistry. 279:8592-8601. 2004
- Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. Journal of Cell Biology. 167:769-781. 2004
- Biologic contribution of P1 promoter-mediated expression of ST6Gal I sialyltransferase. Glycobiology. 13:591-600. 2003
- Increased medial degradation with pseudo-aneurysm formation in apolipoprotein E-knockout mice deficient in tissue inhibitor of metalloproteinases-1. Circulation. 107:333-8. 2003
- Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP). Biochem J. 372:799-809. 2003
- Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. Journal of Cell Biology. 162:1123-33. 2003
- Trans allele methylation and paramutation-like effects in mice. Nat Genet. 34:199-202. 2003
- Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13. FEBS Lett. 532:127-30. 2002
- DNA methylation, imprinting and cancer. Eur J Hum Genet. 10:6-16. 2002
- Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. Nat Genet. 32:426-431. 2002
- Regulation of DNA methylation of Rasgrf1. Nat Genet. 30:92-6. 2002
- Structural characterization of Rasgrf1 and a novel linked imprinted locus. Gene. 291:287-97. 2002
- Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathway. Journal of Biological Chemistry. 276:47402-10. 2001
- Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by MT1-MMP. Biochem Biophys Res Commun. 28:126-30. 2001
- Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development. Mol Genet Metab. 74:293-302. 2001
- MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function. Journal of Biological Chemistry. 276:40215-24. 2001
- Models for gain-of-function and loss-of-function of MMPs. Transgenic and gene targeted mice. Methods Mol Biol. 151:149-79. 2001
- Regulation of hepatic fibrosis and extracellular matrix genes by the the response: new insight into the role of tissue inhibitors of matrix metalloproteinases. J Immunol. 167:7017-26. 2001
- TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol. 12:736-48. 2001
- TIMP-1 promotes VEGF-induced neovascularization in the retina. Histol Histopathol. 16:87-97. 2001
- TIMP-1 promotes VEGF-induced neovascularization in the retina. Histol Histopathol. 16:87-97. 2001
- Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase. Cancer Res. 61:3610-8. 2001
- Effects of gene deletion of the tissue inhibitor of the matrix metalloproteinase-type 1 (TIMP-1) on left ventricular geometry and function in mice. J Mol Cell Cardiol. 32:109-20. 2000
- Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proceedings at the National Academy of Science USA. 97:2202-7. 2000
- Interstitial fibrosis in mice with overload proteinuria: deficiency of TIMP-1 is not protective. Kidney Int. 58:618-28. 2000
- TIMP-2 is required for efficient activation of proMMP-2 in vivo. Journal of Biological Chemistry. 275:26411-5. 2000
- Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2. Journal of Biological Chemistry. 275:41415-23. 2000
- Hyper-resistance to infection in TIMP-1-deficient mice is neutrophil dependent but not immune cell autonomous. Ann N Y Acad Sci. 878:494-6. 1999
- TIMP-1 and TIMP-2 perform different functions in vivo. Ann N Y Acad Sci. 878:519-21. 1999
- The pathogenesis of choroidal neovascularization in patients with age-related macular degeneration. Mol Vis. 5:34. 1999
- Tissue inhibitor of matrix metalloproteinases-1 impairs arterial neointima formation after vascular injury in mice. Circ Res. 85:1186-91. 1999
- Endothelial dysfunction following thrombolysis in vitro. Eur J Vasc Endovasc Surg. 16:494-500. 1998
- Novel implications in the development of endometriosis: biphasic effect of macrophage activation on peritoneal tissue expression of tissue inhibitor of metalloproteinase-1. Am J Reprod Immunol. 40:364-9. 1998
- Pattern of messenger ribonucleic acid expression of tissue inhibitors of metalloproteinases (TIMPs) during testicular maturation in male mice lacking a functional TIMP-1 gene. Biology of Reproduction. 59:364-70. 1998
- Assessment of the role of tissue inhibitor of metalloproteinase-1 (TIMP-1) during the periovulatory period in female mice lacking a functional TIMP-1 gene. Biology of Reproduction. 56:1181-8. 1997
- Nicotine and cotinine stimulate secretion of basic fibroblast growth factor and affect expression of matrix metalloproteinases in cultured human smooth muscle cells, discussion. J Vasc Surg. 24. 1996
- Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host. Oncogene. 13:2307-14. 1996
- Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein. J Immunol. 147:3296-302. 1991
- Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype. J Exp Med. 174:847-58. 1991
- The adenovirus type 5 i-leader open reading frame functions in cis to reduce the half-life of L1 mRNAs. Journal of Virology. 64:551-8. 1990
- Adenovirus L1 52- and 55-kilodalton proteins are required for assembly of virions. Journal of Virology. 63:3612-21. 1989
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chapter
- Data mining as a discovery tool for imprinted genes. Methods Mol Biol. 89-134. 2012
- Data Mining for Imprinted Genes. Genomic Imprinting: Methods and Protocols. 2011
- Data Mining for Imprinted Genes. Genomic Imprinting: Methods and Protocols. 2011
- Elevated Antibacterial Activity in TIMP-1-deficient Mice, In: Tissue Inhibitors in Development and Disease. Harwood Academic Publishers. 159-162. 2000
presentations
speaker at Cornell event
Teaching
teaching activities
- BIOMG-7860: Research Seminar in Genetics and Development - Spring 2013
- NS-8990: Master's Thesis and Research - Spring 2013
- NS-9990: Doctoral Thesis and Research - Spring 2013
- BIOMG-7860: Research Seminar in Genetics and Development - Fall 2012
- BIOMG-7870: Seminar in Genetics and Development - Fall 2012
- NS-4900: Manipulating the Mouse Genome - Fall 2012
- NS-6080: Epigenetics - Fall 2012
- NS-8990: Master's Thesis and Research - Fall 2012
- NS-9990: Doctoral Thesis and Research - Fall 2012
- BIOMG-7800: Current Topics in Genetics and Development - Spring 2012
- BIOMG-7860: Research Seminar in Genetics and Development - Spring 2012
- BIOMG-7870: Seminar in Genetics and Development - Spring 2012
- NS-8990: Master's Thesis and Research - Spring 2012
- NS-9990: Doctoral Thesis and Research - Spring 2012
- BIOMG-6080: Epigenetics - Fall 2011
- BIOMG-7860: Research Seminar in Genetics and Development - Fall 2011
- BIOMG-7870: Seminar in Genetics and Development - Fall 2011
- NS-4000: Directed Readings - Fall 2011
- NS-6080: Epigenetics - Fall 2011
- NS-8990: Master Thesis - Fall 2011
- NS-9990: Doctoral Thesis - Fall 2011
recent courses taught
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NS / BioMG 4900 - Manipulating the Mouse Genome
NS / BioMG 6080 - Epigenetics
Service
current professional activities
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Research: 50%
Teaching: 50%
service to the profession
- External Advisory Board, Albert Einstein College of Medicine Epigenomics Center Board Member 2009 -
- Scientific Advisory Board, Foundation for Angelman Syndrome Therapeutics Board Member 2008 -
- M.S. Student Thesis Committee
- Nanjing Agricultural University
- Rotating Ph.D. Candidates
- US Army Neurofibromatosis Neurofibromatosis-A Adhoc Chairperson - 2003
- Scientific Advisory Board, Association for Research of Childhood Cancer Board Member 1999 - 2000
reviewer or editor for
- Austrian Science Fund START Prize
- Department of Energy, Lab 98-10
- NIH Cancer Center Support Grant, Jackson Lab
- NIH MGB Study Section, February Meeting
- NIH MGB Study Section, October Meeting
- NIH ZRG1 F09-B (20) L Oncology Fellowship Study Section
- Netherlands Genomics Initiative, Horizon Programme Reviewer
- Research Grants Council Hong Kong, China
- US Army Breast Cancer Program, CBY-1 Section
- US Army Breast Cancer Program, SIA-7 Section
- University of Copenhagen Programme of Excellence
- Veterans Affairs Merit Award
- ZRG1 NIH Roadmap Epigenomics of Human Health and Disease Study Section
Background
education and training
- Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Postdoctoral Training
- Whitehead Institute 1994
- MIT 1990
- Ph.D. in, Princeton University, Department of Molecular Biology 1989
- Ph.D. in Molecular Genetics, Princeton University 1989
- B.A. in Department of Biochemistry, Cornell University 1979
Other
college
- CALS
name suffix
- Ph D