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Brenna, Tom
Cornell Faculty Member
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Positions
- Professor, Division of Nutritional Sciences (DNS), College of Agriculture and Life Sciences (CALS)
- Professor, Food Science (FOOD), College of Agriculture and Life Sciences (CALS)
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Overview
Affiliations
head of
member of graduate field
other Cornell affiliations
advisory group member
Research
research activities
principal investigator on
- BRANCHED CHAIN FA AND GUT DEVELOPMENT awarded by NATL INST OF CHILD HEALTH & HUMAN DEVELOPMENT, NIH 2010 - 2013
- BRANCHED CHAIN FATTY ACIDS (BCFA), GUT MICROBIOTA, AND PREVENTION OF CHILDHOOD OBESITY awarded by NATIONAL INSTITUTE OF FOOD AND AGRICULTURE-USDA 2012 - 2014
- CHARACTERIZATION OF THE HUMAN URINARY STEROIDOME FOR ANTIDOPING APPLICATIONS awarded by PARTNERSHIP FOR CLEAN COMPETITION 2009 - 2012
- EFFICACY OF DIETARY DOCOSAHEXAENOIC ACID (DHA) AS A TRIGLYCERIDE OF PHOSPHOLIPIDS awarded by BNL FOOD 2012 - 2013
- EFFICACY OF DIETARY DOCOSAHEXAENOIC ACID (DHA) AS A TRIGLYCERIDE OR PHOSPHOLIPIDS awarded by DANONE RESEARCH B.V. 2012 - 2013
- GCX(PY)GCC-IRMS FOR ISOTOPE METABOLOMICS awarded by NATL INST OF GENERAL MEDICAL SCIENCES, NIH 2010 - 2015
submitted impact statement
Publications
individual publications
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academic article
- Calibration and Data Processing in Gas Chromatography Combustion Isotope Ratio Mass Spectrometry.. Drug Testing and Anaysis. 4:912-922. 2012
- Examination of the Kinetic Isotopic Effect to the Acetylation Derivatisation of the Gas Chromatographic-Combustion-Isotope Ratio Mass Spectrometry of Endogenous Steroids for Doping Control Analysis.. Drug Testing and Analysis. 4:923-927. 2012
- Production of isotopically labeled standards from a uniformly labeled precursor for quantitative volatile metabolomic studies.. Analytical Chemistry. 84:5400-5406. 2012
- Structural Characterization of Saturated Branched Chain Fatty Acid Methyl Esters by Collisional Dissociation of Electron Impact Activated Molecular Ions. Journal of Lipid Research. 53:195-203. 2012
- Acetonitrile covalent adduct chemical ionization tandem mass spectrometry of non-methylene interrupted pentaene fatty acid methyl esters. Rapid Communications in Mass Spectrometry. 25:1933-1941. 2011
- Animal Studies Of The Functional Consequences Of Sub-Optimal Polyunsaturated Fatty Acid Status During Pregnancy, Lactation And Early Postnatal Life. Maternal and Child Nutrition. 7. 2011
- Branched chain fatty acid content of US retail cow’s milk and implications for dietary intake. Lipids. 46:569-576. 2011
- Branched chain fatty acids reduce the incidence of necrotizing enterocolitis in a neonatal rat model and alter gastrointestinal microbial ecology. PLoS One. 6. 2011
- Comprehensive Two Dimensional Gas Chromatography Fast Quadrupole Mass Spectrometry (GC×GC-qMS) for Urinary Steroid Profiling. Mass Spectral Characteristics with Chemical Ionization. Drug Testing and Analysis. 3:857-867. 2011
- Detection of Synthetic Testosterone Use by Novel Comprehensive Two-Dimensional Gas Chromatography Combustion Isotope Ratio Mass Spectrometry. Analytical Chemistry. 8:7158-7165. 2011
- Does aging change docosahexaenoic acid homeostasis? Implications for the challenge to cognitive health in the elderly. O Oleagineux, Corps Gras, Lipides (OCL). 18:175-180. 2011
- Evaluation of bioequivalency and toxicological effects of three sources of arachidonic acid (ARA) in domestic piglets. Food Chemistry Toxicology. 49:2320-2327. 2011
- FADS2 Function Loss at the Cancer Hotspot 11q13 Locus Diverts Lipid Signaling Precursor Synthesis to Unusual Eicosanoid Fatty Acids. PLoS One. 6. 2011
- Folate intake, Mthfr genotype and sex modulate choline metabolism in mice. Journal of Nutrition. 141:1475-1481. 2011
- Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid (ARA) and DHA. British Journal of Nutrition. 1:1-8. 2011
- Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets.. Prostaglandins, Leukotrienes and Essential Fatty Acids. 85:335-343. 2011
- MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline. American Journal of Clinical Nutrition. 93:348-355. 2011
- Mammalian DNA d15N exhibits 40‰ intramolecular variation and is unresponsive to dietary protein level. Rapid Communications in Mass Spectrometry. 25:3555-2562. 2011
- Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertile. Developmental Biology. 348:177-189. 2011
- PTB/hnRNP I regulates fatty acid desaturase alternative splicing and cellular omega-3 fatty acid composition. Journal of Lipid Research. 52:2279-2286. 2011
- Plasma Incorporation, Apparent Retroconversion And Beta-Oxidation Of 13C-Docosahexaenoic Acid In The Elderly. Nutrition and Metabolism. 27:5. 2011
- The polypyrimidine tract binding protein regulates desaturase alternative splicing and PUFA composition. Journal of Lipid Research. 52:2279-2286. 2011
- Altered cholesterol and fatty acid metabolism in Huntington disease. Journal of Clinical Lipidology. 4. 2010
- Alternative transcripts of fatty acid desaturase (FADS) genes. Prostaglandins, Leukotrienes and Essential Fatty Acids. 82:281-285. 2010
- Dose-response effects of betamethasone on maturation of the fetal sheep lung. American journal of obstetrics and gynecology. 202. 2010
- Microfabrication of High Temperature Micro-Reactors for Continuous Flow Isotope Ratio Mass Spectrometry. Microfluidics & Nanofluidics. 9:461-470. 2010
- Individual trans octadecenoic acids and partially hydrogenated vegetable oil differentially effect hepatic lipid and lipoprotein metabolism in Golden Syrian Hamsters. Journal of Nutrition. 139:257-263. 2009
- Comprehensive Two-Dimensional Gas Chromatography Combustion Isotope Ratio Mass Spectrometry. Analytical Chemistry. 80 :8613. 2008
- Fast gas chromatography combustion isotope ratio mass spectrometry. Analytical Chemistry. 79:6348-6358. 2007
- Absolute determination of position specific isotope ratios of lactic acid analogues. Analytical Chemistry. 78:2752. 2006
- 15N/14N position specific isotopic analyses of polynitrogenous amino acids. Analytical Chemistry. 77:1013. 2005
- Carbon position-specific isotope analysis of alanine and phenylalanine analogues exhibiting nonideal pyrolytic fragmentation. Analytical Chemistry. 77:1746. 2005
- Milk fat synthesis is unaffected by abomasal infusion of the conjugated diene 18:3 isomers cis-6, trans-10, cis-12 and cis-6, trans-8, cis-12. Lipids. 40:89-95. 2005
- Analysis of Quantization Error in High Precision Continuous Flow Isotope Ratio Mass Spectrometry. Journal of Chromatography. 1020:273-282. 2003
- High Precision Position Specific Isotope Analysis of 13C/12C in Methionine and Leucine Analogues. Analytical Chemistry. 75:5495-5503. 2003
- Identification and characterization of conjugated fatty acid methyl esters of mixed double bond geometry by acetonitrile chemical ionization tandem mass spectrometry. Anal. Chem.. 75:4925-4930. 2003
- High precision isotope mass spectrometry and stable isotope precursors for tracer studies in cell culture. Analytical Biochemistry. 287:80-86. 2000
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chapter
- Lipid structure, nomenclature, and chemical properties. Chapter 6 in Nutritional Biochemistry. 91-119. 2011
- Metabolic and Molecular Aspects of the Critical Role of Docosahexaenoic Acid in Human Brain Function. Environmental Influences on Human Brain Evolution. 2010
- Lipid Structure, Nomenclature, and Chemical Properties. Nutritional Biochemistry. 2006
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conference paper
- Alternative splicing of fatty acid desaturases is associated with altered fatty acid composition. Experimental Biology. 2011
- Ammonia positive chemical ionization for high sensitivity and specificity comprehensive GC×GC-quadrupole MS of urinary steroid identification and quantification. 30th Manfred Donike Workshop on Antidoping Science. 2011
- Comprehensive GC×GCC-IRMS analyses of urinary steroids for doping control: Initial results. 30th Manfred Donike Workshop on Antidoping Science. 2011
- Data processing challenges in coupling GCxGC with online high precision isotope ratio mass spectrometry (IRMS). Eighth GC×GC Symposium Proceedings. 2011
- Evaluation of bioequivalency and toxicological effects of three sources of arachidonic acid (ARA) in domestic piglets. Experimental Biology. 2011
- Identification and quantification of acetylated urinary steroids by comprehensive GC×GC-fast quadrupole MS using ammonia positive chemical ionization. 59th ASMS Conference on Mass Spectrometry and Allied Topics Proceedings. 2011
- NH3 positive chemical ionization for high sensitivity and specificity GC×GC-quadrupole MS of urinary steroid identification and quantification. Eighth GC×GC Symposium Proceedings. 2011
- NH3 positive chemical ionization for high sensitivity and specificity GC×GC-quadrupole MS of urinary steroid identification and quantification. International Separation Science Society CASSS Joint Congress. 2011
- Progress towards urinary steroids analysis by GC×GC coupled to IRMS for the detection of synthetic steroid use in sport doping,. Eighth GC×GC Symposium Proceedings. 2011
- Towards detection of synthetic steroid use in sport doping using GC×GC-C-IRMS analysis of urinary steroids. 59th ASMS Conference on Mass Spectrometry and Allied Topics Proceedings. 2011
- Towards detection of synthetic steroid use in sport doping using GC×GC-C-IRMS analysis of urinary steroids. International Separation Science Society CASSS Joint Congress. 2011
- Acetonitrile covalent adduct chemical ionization tandem mass spectrometry (CACI-MS/MS) for identification of highly unsaturated fatty acids produced by partial hydrogenation of DHA oil. Proceedings of the 8th Euro Fed Lipid Congress: Oils, Fats and Lipids: Health & Nutrition, Chemistry & Energy, Munich. 2010
- Branched Chain Fatty Acids are taken up and metabolized by Cultured Human Intestinal Cells (Caco-2). Experimental Biology Proceedings 2010, Anaheim, Ca.. 2010
- Comprehensive Two Dimensional Gas Chromatography Combustion Isotope Ratio Mass Spectrometry (GC×GCC-IRMS) Determination of 13C/12C Ratios of Native Endogenous Urinary Steroids. Proceedings of the 58th ASMS Conference on Mass Spectrometry conference, Salt Lake City, UT. 2010
- Cultured human intestinal cells take up and metabolize branched chain fatty acids. Proceedings of the International Society for the Study of Fatty Acids and Lipids, ISSFAL 2010, Maastricht, The Netherlands. 2010
- Dietary LCPUFA Upregulate FADS3 Alternative Transcripts in Neonatal Baboon Liver. Experimental Biology 2010, Anaheim, Ca. 2010
- Effect of dietary arachidonic acid (ARA) levels on growth and clinical chemistry in domestic piglets. Proceedings of the International Society for the Study of Fatty Acids and Lipids, ISSFAL 2010, Maastricht, The Netherlands. 2010
- Fatty acid desaturase alternatve splice variants are widely expressed and localize to the mitochondria. Proceedings of the International Society for the Study of Fatty Acids and Lipids, ISSFAL 2010, Maastricht, The Netherlands. 2010
- High-Precision Measurement of 13C/12C in Short Chain Hydrocarbons Using a Novel Micro-Fabricated Micro-Reactor Interface For Gas Chro-matography-Combustion- Cavity Ring-Down Spectroscopy. Proceedings of the 58th ASMS Conference on Mass Spectrometry conference, Salt Lake City, UT. 2010
- Humans require omega-3 docosahexaenoic acid to achieve optimal brain and retinal fatty acid composition. Proceedings of The International Seafood and Health Conference & Exhibition, Melbourne, Australia. 2010
- Microfabrication of On-line Micro-Reactors for Gas Chromatography Isotope Ratio Mass Spectrometry (GC-IRMS) . Proceedings of the 58th ASMS Conference on Mass Spectrometry conference, Salt Lake City, UT. 2010
- Novel FADS1 transcripts generated by alternative polyadenylation, alternative transcription initiation and alternative splicing. Proceedings of the American Society of Human Genetics Annual meeting, Washington, DC. 2010
- The Effects of EPA, DHA, and Aspirin ingestion on plasma lysophospholipids and autotaxin. Proceedings of the International Society for the Study of Fatty Acids and Lipids, ISSFAL 2010, Maastricht, The Netherlands. 2010
- The methylene-interrupted cis double-bonded PUFA (Homoallylic) motif may form a double helix with transmembrane protein a-helices. Proceddings of the International Society for the Study of Fatty Acids and Lipids, ISSFAL 2010, Maastricht, The Netherlands. 2010
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document part
- Data processing challenges in coupling GCxGC with online high precision isotope ratio mass spectrometry (IRMS) 2011
- Comprehensive Two Dimensional GC (GCxGC)-TOF-MS Detection of Urinary Steroids 2009
- Urinary Steroidomics by Comprehensive Two Dimensional Gas Chromatography-TOF (2D GC×GC-TOF) and Isotope Ratio Mass Spectrometry (IRMS). Instrumentation and Application to Sports Antidoping 2009
- Comprehensive two-dimensional gas chromatography combustion isotope ratio mass spectrometry (GCxGC-C-IRMS). 8613. 2008
- Data analysis in GCC-IRMS 2007
- Fast Gas Chromatography-Combustion Isotope Ratio Mass Spectrometry 2007
- Acetonitrile chemical ionization tandem mass spectrometry for the identification of trans and conjugated fatty acid methyl ester isomers in milk fat 2002
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report
presentations
featured in archived article
Teaching
teaching activities
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Spring 2013
- FDSC-6960: Graduate Internship in Food Science - Spring 2013
- FDSC-8900: Master's Level Thesis Research - Spring 2013
- FDSC-9900: Doctoral-Level Thesis Research - Spring 2013
- NS-4444: Sports Nutrition and Supplements, Concepts and Evidence - Spring 2013
- NS-8990: Master's Thesis and Research - Spring 2013
- NS-9990: Doctoral Thesis and Research - Spring 2013
- CHEM-6280: Trace Element and Isotopic Analysis - Fall 2012
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Fall 2012
- FDSC-6960: Graduate Internship in Food Science - Fall 2012
- FDSC-6970: Graduate Individual Study in Food Science - Fall 2012
- FDSC-8900: Master's Level Thesis Research - Fall 2012
- FDSC-9900: Doctoral-Level Thesis Research - Fall 2012
- NS-6900: Trace Element and Isotopic Analysis - Fall 2012
- NS-8990: Master's Thesis and Research - Fall 2012
- NS-9990: Doctoral Thesis and Research - Fall 2012
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Spring 2012
- FDSC-6960: Graduate Internship in Food Science - Spring 2012
- FDSC-8900: Master's Level Thesis Research - Spring 2012
- FDSC-9900: Doctoral-Level Thesis Research - Spring 2012
- NS-4444: Sports Nutrition and Supplements, Concepts and Evidence - Spring 2012
- NS-8990: Master's Thesis and Research - Spring 2012
- NS-9990: Doctoral Thesis and Research - Spring 2012
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Fall 2011
- FDSC-6960: Graduate Internship in Food Science - Fall 2011
- FDSC-8900: Masters-Level Thesis Research - Fall 2011
- FDSC-9900: Doctoral-Level Thesis Research - Fall 2011
- NS-4000: Directed Readings - Fall 2011
- NS-8990: Master Thesis - Fall 2011
- NS-9990: Doctoral Thesis - Fall 2011
recent courses taught
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NS 4444 - Sports Nutrition & Supplements: Concepts and Evidence. Spring.
NS 6900/Chem 6280 - Isotopic and Elemental Analysis. Fall.
NS 6430 - Macronutrients. Spring (Team-taught)
NS 6200 - Translational Research and Evidence-based Policy and Practice in Nutrition. Spring (Team-taught)
Service
current professional activities
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Cornell University Graduate Field Memberships: Nutrition; Chemistry and Chemical Biology; Geological Sciences; Food Science and Technology.
President(-Elect), International Society for the Study of Fatty Acids and Lipids, ISSFAL
Co-Organizer, Mass Spectrometry in Food Safety and Quality. ASMS Asilomar Conference on Mass Spectrometry, October 2012.
Editorial Board, Fats of Life Newsletter
First Editor/Editorial Board, British Journal of Nutrition
Editorial Board, Rapid Communications in Mass Spectrometry
service to the profession
- Shriners Hospital for Children and Burn Unit, and University of Texas Medical Branch Board of Advisors 2012 -
- NIH National Resource for Accelerator Mass Spectrometry Board of Advisors 1999 -
reviewer or editor for
event host
Background
education and training
- PhD degree in Analytical Chemistry, Cornell University 1985
- M.S. in Analytical Chemistry, Cornell University 1982
- B.S. in Nutritional Biochemistry, University of Connecticut 1980