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Research
research overview
My program in both Teaching and Research has exploited my varied background and experience in applying science to the understanding of the physiological constraints to animal production and broader areas - viz. animal biotechnologies and human reproductive mechanisms. In addition to a detailed analysis of the maturation of mammalian oocytes, recent work has been aimed at a description of the transcriptome of bovine oocytes at the germinal vesicle stage, the key starting material for many embryo biotechnologies. As I am winding down research activity, I was willing to take the lead, on behalf of the department during 2008, in establishing a repository of genomic DNA for the 1000+ cattle at the T&R Center. This material will provide a unique resource for later genotyping of animals for which we have an enormous production-performance database already in place and expected to continue indefinitely.
keywords
Integrative whole animal physiology
biology of pregnancy
cell cycle regulation
cellular and molecular approaches
mammalian oocyte maturation
very early mammalian embryogenesis and developmental biology
submitted impact statement
Publications
individual publications
academic article
Pregnancy rates in lactating dairy cattle following supplementation of progesterone after artificial insemination .
Animal Reproduction Science .
102:172-179.
2007
Adenylyl cyclases in oocyte maturation: a characterization of AC isoforms in bovine cumulus cells .
Molecular Reproduction and Development .
73:1202-1210.
2006
Antibody directed against plasma membrane components of equine spermatozoa inhibits adhesion of spermatozoa to oviduct epithelial cells in vitro .
Biology of Reproduction .
56:720-730.
1997
Dynamics of Maturation Promoting Factor (MPF) and its constituent proteins during in vitro maturation of bovine oocytes .
Biology of Reproduction .
56:253-259.
1997
Expression of c-mos proto-oncoprotein in bovine oocytes during maturation in vitro .
Biology of Reproduction .
56:260-267.
1997
Reduced fertility associated with low progesterone post-breeding and increased milk urea nitrogen in lactating cows .
Journal of Dairy Science .
80:1288-1295.
1997
Characterization of polypeptides synthesized and secreted by oviductal epithelial cell explants obtained from young, fertile and aged, subfertile mares .
American Journal of Veterinary Research .
57:1346-1353.
1996
Effect of chronic infusion of placental lactogen on ovine fetal growth in late gestation .
Domestic Animal Endocrinology .
13:519-528.
1996
Temporal distinctions in the synthesis and accumulation of proteins by oocytes and cumulus cells during maturation in vitro of bovine oocytes .
Molecular Reproduction and Development .
45:560-565.
1996
Effect of coculture with stallion spermatozoa on de novo protein synthesis and secretion by equine oviduct epithelial cells .
American Journal of Veterinary Research .
56:1657-1662.
1995
Isolation, culture, and characterization of equine oviduct epithelial cells in vitro .
Molecular Reproduction and Development .
41:468-478.
1995
Effects of testosterone on skeletal growth in lambs as assessed by labelling index of chondrocytes in the metacarpal bone growth plate .
Journal of Animal Science .
72:2629-2634.
1994
De novo protein synthesis by bovine uterine tube (oviduct) epithelial cells changes during co-culture with bull spermatozoa .
Biology of Reproduction .
48:851-856.
1993
Effects of chimerism in sheep-goat concepti that developed from blastomere-aggregation embryos .
Biology of Reproduction .
48:889-904.
1993
Effect of fibronectin on early embryo development in cows .
Journal of Reproduction and Fertility .
96:289-297.
1992
Platelet derived growth factor (PDGF) stimulates development of bovine embryos during the fourth cell cycle .
Development .
115:821-826.
1992
The kinetics of placental lactogen in mid- and late-gestation ovine fetuses .
Journal of Endocrinology .
133:95-100.
1992
Transforming growth factor ß and basic fibroblast growth factor synergistically promote early bovine embryo development during the fourth cell cycle .
Molecular Reproduction & Development .
33:432-435.
1992
Caprine placental lactogen: purification, partial characterization, and development of a specific radioimmunoassay .
Journal of Reproduction and Fertility .
90:25-36.
1990
Chronic heat stress and prenatal development in sheep. I. Conceptus growth and maternal plasma hormones and metabolites .
Journal of Animal Science .
67:3289-3299.
1990
Differential control of placental lactogen release and progesterone production by ovine placental tissue in vitro .
Placenta .
11:337-348.
1990
Effects of N-acetylimidazole on oxytocin binding in mammary tissue .
Journal of Receptor Research .
10:287-298.
1990
Synthesis and release of peptides produced by equine trophoblastic vesicles in vitro .
Theriogenology .
33:187.
1990
Endocrine and histologic correlates of the dynamics of the metacarpal growth plate in growing rams .
Journal of Animal Science .
67:3124-3135.
1989
Dietary calcium and metacarpal growth in ewes .
Journal of Nutrition .
118:976-981.
1988
Elevated concentration of 13,14-dihydro, 15 keto-prostaglandin F2-alpha in maternal plasma during prepartum luteolysis and parturition in dogs (Canis familiaris) .
Journal of Reproduction and Fertility .
84:71-77.
1988
Endocrine changes, with special emphasis on oestradiol-17B, prolactin and oxytocin, before and during labour and delivery in goats .
Journal of Reproduction and Fertility .
82:299-308.
1988
Fetal development, and placental and maternal plasma concentrations of progesterone in the Little Brown Bat (Myotis lucifugus) .
Journal of Reproduction and Fertility .
82:401-407.
1988
Variation in plasma concentrations of estradiol 17B and their relationship to those of progesterone, 13,14-dihydro-15-keto-prostaglandin F2 and oxytocin across pregnancy and at parturition in pony mares .
Journal of Reproduction and Fertility .
84:635-646.
1988
Electromyographic (EMG) properties of the myometrium correlated with the endocrinology of the pre-partum and post-partum periods and parturition in pony mares .
Journal of Reproduction and Fertility .
(Suppl.) 35:533-564.
1987
Electromyographic properties of the myometrium of pony mares during pregnancy .
Journal of Reproduction and Fertility .
81:471-478.
1987
Regulation of nutrient partitioning and metabolism during pre- and postnatal growth .
Journal of Animal Science .
65:1826-212.
1987
Variation in the oxytocin content of caprine corpora lutea across the breeding season .
Theriogenology .
23:481-486.
1985
Half-life, clearance and production rate for oxytocin in cattle during lactation and mammary involution .
Domestic Animal Endocrinology .
1:121-140.
1984
Oxytocin concentrations of cattle in response to milking stimuli through lactation and mammary involution. II .
Domestic Animal Endocrinology .
1:141-154.
1984
Toxicologic studies with pregnant goats fed grass-legume silage grown on municipal sludge-ammended sub-soil .
Archives of Environmental Contamination and Toxicology .
13:635-640.
1984
Uterine steroid receptor changes associated with progesterone withdrawal during pregnancy and pseudo-pregnancy in rabbits .
Endocrinology .
114:182-191.
1984
Changes in the responsiveness of adrenal cells fromfoetal goats at different times during pregnancy .
Acta Endocrinologica .
102:122-128.
1983
Hormonal effects on partitioning of nutrients for tissue growth: role of growth hormone and prolactin .
Fed. Proc .
41:2538.
1982
Enhanced excitability of the uterus of the pregnant rabbit by imidazole stimulation of cyclic AMP phosphodiesterase .
Journal of Reproduction and Fertility .
60:369-375.
1980
Partitioning of nutrients during pregnancy and lactation. A review of mechanisms involving homeostasis and homeorhesis .
Journal of Dairy Science .
63:1514-1529.
1980
In vitro action of progesterone on myometrium. I. Reversible modulation of the resistance of rabbit uterus to excitation-contraction uncoupling .
Biology of Reproduction .
21:945-952.
1979
The effect of passive immunization against estradiol on the regulatory profile and character of labor in the rat .
American Journal of Obstetrics and Gynecology .
132:464-470.
1978
Caprine placental lactogen: levels of prolactin-like and growth hormone-like activities in the circulation of pregnant goats determined by radioreceptor assays .
Journal of Endocrinology .
73:215-226.
1977
Control of Parturition in Domestic Animals .
Biology of Reproduction .
16:18-27.
1977
Parturition in goats: studies on interactions between the foetus, placenta, prostaglandin F and progesterone before parturition, at term or at parturition induced prematurely by corticotrophin infusion of the foetus .
Journal of Endocrinology .
73:263-278.
1977
Release of prostaglandin F, regression of corpora lutea and induction of premature parturition in goats treated with estradiol-17beta .
Prostaglandins .
12:1093-1103.
1976
Secretion rate of prostaglandin F during induced labor in goats .
Prostaglandins .
9:867-879.
1975
Luteal function in hysterectomized goats .
Journal of Reproduction and Fertility .
41:501-504.
1974
Regression of the corpus luteum of pregnancy and initiation of labour in goats .
Journal of Reproduction and Fertility .
36:481-482.
1974
Induction of premature parturition in goats by prostaglandin F2alpha administered into the uterine vein .
Prostaglandins .
4:201-214.
1973
Prostaglandin F and progesterone concentrations in the utero-ovarian venous plasma of the ewe during the oestrous cycle and early pregnancy. .
Journal of Reproduction and Fertility .
18 (Suppl.):151-158.
1973
Prostaglandin F-group (PGF), progesterone, and estrogen concentrations in the uteroovarian venous plasma of the conscious ewe during the estrous cycle .
Advances in the Biosciences .
9:625-630.
1973
Spontaneous or dexamethasone-induced parturition in the sheep and goat: changes in plasma concentrations of maternal prostaglandin F and foetal oestrogen sulphate .
Mem. Soc. Endocrinol. .
20:95-118.
1973
Prostaglandin F concentration in the utero-overian venous plasma of the ewe during the oestrous cycle .
Journal of Endocrinology .
53:325-326.
1972
Relationships between milk and milk fat composition and trans-lactational changes in mammary gland enzyme activities in grazing cattle .
Australian Journal of Biological Sciences .
25:1341-1349.
1972
Sources of variation in the fatty acid composition of milk fat from monozygous twin cattle housed indoors .
New Zealand Journal of Agricultural Research .
15:260-266.
1972
Trans-lactational changes in the activities of selected enzymes in biopsy samples of the bovine mammary gland .
Australian Journal of Biological Sciences .
25:1333-1340.
1972
book
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conference paper
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Physiology of uterine activity
1980
Teaching
teaching overview
In Fall, 2008 in addition to my regular ANSC 1100 responsibility, I offered a one-time substitute class in endocrinology for senior students seeking an advanced treatment of the topic in lieu of the regular endocrinology class not being offered.
teaching activities
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research keyword
Integrative whole animal physiology
biology of pregnancy
cell cycle regulation
cellular and molecular approaches
mammalian oocyte maturation
very early mammalian embryogenesis and developmental biology
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