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Todhunter, Rory James
Cornell Faculty Member
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Positions
- Professor, Clinical Sciences (VETCS), College of Veterinary Medicine
- Dept Chairperson Assoc, Clinical Sciences (VETCS), College of Veterinary Medicine
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Research
research overview
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Osteoarthritis: Over the last 10 years, Dr. Todhunter's research investigations have focused on the problem of hip dysplasia in dogs. The process by which hip dysplasia in dogs has been investigated has mostly focused on pathogenesis, diagnosis and treatment. He is bringing contemporary methods to bear on this major canine problem. His focus has been:
- To reduce the false positive and negative diagnoses that arise with the current radiographic methods to diagnose hip dysplasia with an imaging method called the dorsolateral subluxation test; and
- To find genetic markers for the traits underlying hip dysplasia in dogs and, in the long term, the mutations that predispose to these traits and their concomitant osteoarthritis.
He has undertaken a genome-wide screen on an experimental pedigree of Greyhounds and dysplastic Labrador Retrievers. With a combination of linkage and linkage disequilibrium mapping, he and his group has identified chromosomal regions harboring the genes that confer susceptibility to, and protect against, canine hip dysplasia. Now they need to narrow these regions by testing for conserved regions that harbor these mutations across breeds.
co-principal investigator on
Publications
individual publications
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academic article
- Principal component analysis of canine hip dysplasia phenotypes and their statistical power for genome-wide association mapping.. Journal of Applied Statistics.. 40:235-251. 2013
- Femoral Head Bone Mineral Density Patterns May Identify Hips at Risk of Degeneration. Annals of Biomedical Engineering. 39. 2010
- Development and use of DNA archives at veterinary teaching hospital to investigate the genetic basis of disease. Journal of the American Veterinary Medical Association. 234:75-80. 2009
- Magnetic resonance imaging subarticular bone marrow lesions in dogs with stifle lameness. Veterinary Radiology and Ultrasound. 48:312-317. 2007
- Effect of Early Postnatal Body Weight on Femoral Head Ossification Onset and Hip Osteoarthritis in a Canine Model of Developmental Dysplasia of the Hip. Pediatric Research. 60:549-554. 2006
- Analysis of allele fidelity, polymorphic information content, and density of microsatellites in a genome wide screening for hip dysplasia in a cross breed pedigree. Journal of Heredity. 96:847-853. 2005
- Quantitative trait loci for hip dysplasia in a crossbreed canine pedigree. Mammalian Genome. 16:720-30. 2005
- Quantitative genetics of traits associated with hip dysplasia in a Labrador Retriever-Greyhound pedigree. American Journal of Veterinary Research. 63:1029-1035. 2002
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chapter
- QTL Mapping Using Cross Breed Pedigrees: Strategies for Canine Hip Dysplasia. The Dog and Its Genome. 407-438. 2005
selected publications listing
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- Zhu L, Zhang Z, Schweitzer P, Phavaphutanon J, Vernier-Singer M, Corey E, Friedenberg S, Mateescu R, Williams A, Lust G, Acland G, Todhunter R. Refined quantitative trait loci intervals for hip joint laxity in dogs. Anim Genetics, 39(2):141-6, 2008.
- Winegardner KR, Scrivani PV, Krotscheck U, Todhunter RJ. Magnetic resonance imaging of subarticular bone marrow lesions in dogs with stifle lameness. Vet Radiol Ultrasound 48(4):312-317, 2007.
- Liu T, Todhunter RJ, Wu S, Hou W, Mateescu R, Zhang Z, Burton-Wurster NI, Acland GM, Lust G, Wu R. A random model for mapping imprinted quantitative trait loci in a structured pedigree: an implication for mapping canine hip dysplasia. Genomics 90(2):276-284, 2007.
- Kerns JA, Cargill EJ, Clark LA, Candille SI, Berryere TG, Olivier M, Lust G, Todhunter RJ, Schmutz SM, Murphy KE, Barsh GS. Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics 176(7):1-11, 2007.
- Zhang Z, Todhunter RJ, Buckler ES, Van Vleck LD: Technical note: use of marker-based relationships with multiple-trait derivative-free restricted maximal likelihood. J Anim Sci 85(4):881-885, 2007.
- Hays L, Zhang Z, Mateescu RG, Lust G, Burton-Wurster NI, Todhunter RJ: Quantitative genetics of secondary hip joint osteoarthritis in a Labrador Retriever-Greyhound pedigree. Am J Vet Res 68(1):35-41, 2007.
- Watts AE, Fubini SL, Vernier-Singer M, Golkowski C, Shin S, Todhunter RJ: In vitro analysis of nonthermal plasma as a disinfecting agent. Am J Vet Res 67(12):2030-2035, 2006.
- Thoesen MS, vandenBerg-Foels WS, Stokol T, Rassnick KM, Jacobson MS, Kevy SV, Todhunter RJ: Use of a centrifugation-based point-of-care device for production of canine autologous bone marrow and platelet concentrations. Am J Vet Res 67(10):1655-1661, 2006.
- vandenBerg-Foels WS, Todhunter RJ, Schwager SJ, Reeves AP: Effect of early postnatal body weight on femoral head ossification onset and hip osteoarthritis in a canine model of developmental dysplasia of the hip. Pediatr Res 60(5):549-554, 2006.
- Chalmers HJ, Dykes NL, Lust G, Farese JP, Burton-Wurster NI, Williams AJ, Todhunter RJ: Assessment of bone mineral density of the femoral head in dogs with early osteoarthritis. Am J Vet Res 67(5):796-800, 2005.
- Todhunter RJ, Mateescu R, Lust G, Burton-Wurster NI, Dykes NL, Bliss SP, Williams AJ, Vernier-Singer M, Corey E, Harjes C, Quaas RL, Zhang Z, Gilbert RO, Volkmann D, Casella G, Wu R, Acland GM: Quantitative trait loci for hip dysplasia in a crossbreed pedigree. Mamm Genome16(9):720-730, 2005.
- Todhunter RJ, Mateescu RG, Zhang Z, Dykes NL, Burton-Wurster NI, Lust G. Diagnosis and genetic loci mapping for canine hip dysplasia. Veterinary Forum 22(8):39-44, 2005.
- Mateescu RG, Zhang Z, Tsai K, Phavaphutanon J, Burton-Wurster NI, Lust G, Quaas R, Murphy K, Acland GM, Todhunter, RJ: Analysis of allele fidelity, polymorphic information content, and density of microsatellites in a genome-wide screening for hip dysplasia in a crossbreed pedigree. J Hered 96(7):847-853, 2005.
- Burton-Wurster N, Mateescu RG, Todhunter RJ, Clements KM, Sun Q, Scarpino V, Lust G: Genes in canine articular cartilage that respond to mechanical injury: gene expression studies with Affymetrix canine GeneChip. J Hered 96(7):821-838, 2005.
- Aguila AZ, Manos JM, Orlansky AS, Todhunter RJ, Trotter EJ, van der Meulen MCH: In vitro biomechanical comparison of limited contact dynamic compression plate and locking compression plate. Vet Comp Orthop Traumatol 18(4):220-226, 2005.
- Mateescu R, Todhunter RJ, Lust G, Burton-Wurster N: Increased MIG-6 mRNA transcripts in osteoarthritic cartilage. Biochem Biophys Res Commun 332(2):482-486, 2005.
- Xiang-Yang L, Casella G, Todhunter RJ, Wu R: A general statistical framework for unifying interval and linkage disequilibrium mapping: towards high-resolution mapping of quantitative traits. J Am Stat Assoc 100:158-71, 2005.
- Steffey MA, Miura N, Todhunter RJ, Nykamp SG, Freeman KP, Scarpino V, Vernier-Singer MA, Erb HN, MacLeod JN, Lust G, Burton-Wurster N: The potential and limitations of cartilage-specific (V+C)(-) fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid. Osteoarthritis Cartilage 12(10):818-825, 2004.
- Todhunter RJ, Bliss SP, Casella G, Wu R, Lust G, Burton-Wurster NI, Williams AJ, Gilbert RO, Acland G. Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree. J Hered 94(1); 39-48, 2003.
- Todhunter RJ, Casella G, Bliss SP, Lust G, Williams AJ, Hamilton S, Dykes NL, Yeager A, Gilbert RO, Burton-Wurster N, Mellersh CC, Acland GM. Power of a dysplastic Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia. Am J Vet Res 64: 418-424, 2003.
- Todhunter RJ, Bertram JE, Smith S, et al. Effect of dorsal hip loading, sedation, and general anesthesia on dorsolateral subluxation score in dogs. Vet Surgery 32(3): 196-205, 2003.
- Todhunter RJ, Grohn YT, Bliss SP, Wilfand A, Williams AJ, Vernier-Singer M, Burton-Wurster N, Dykes NL, Wu R, Casella G, Acland GM, Lust G: Evaluation of multiple radiographic predictors of cartilage lesions in the hip joints of 8-month-old dogs. Am J Vet Res 64:1472-1478, 2003.
- Mertens WD, Macleod JN, Fubini SL, Vernier-Singer M, Nixon AJ, Todhunter RJ: Polysulfated glycosaminoglycans modulate transcription of interleukin-treated chondrocytes in monolayer culture. Vet Comp Orthop Traumatol 2: 93-98, 2003.
- Kennedy S, Lee DV, Bertram JEA, Bliss SP, Williams AJ, Soderholm V, Lust GL, Todhunter RJ: Analysis of ground reaction forces from serial force platforms in dogs with normal and osteoarthritic hips. Vet Comp Orthop Traumatol 16:170-177, 2003.
- Todhunter RJ, Bliss SP, Casella G, Wu R, Lust G, Burton-Wurster NI, Williams AJ, Gilbert RO, Acland G. Genetic structure of susceptibility traits for hip dysplasia and microsatellite informativeness of an outcrossed canine pedigree. J Hered 94:39-48, 2003.
- Todhunter RJ, Casella G, Bliss SP, Lust G, Williams AJ, Hamilton S, Dykes NL, Yeager A, Gilbert RO, Burton-Wurster N, Mellersh CC, Acland GM. Power of a dysplastic Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia. Am J Vet Res 64:418-424, 2003.
- Lou X-Y, Todhunter RJ, Lin M, Lu Q, Liu T, Bliss SP, Casella G, Acland GM, Lust G, Wu R. The extent and distribution of linkage disequilibrium in canine. Mamm Gen. Aug;14(8):555-64, 2003.
- Bliss S, Todhunter RJ, Quaas R, Casella G, Wu R, Lust G, Williams AJ, et al. Quantitative genetics of traits associated with canine hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers and unaffected Greyhounds. Am J Vet Res 63:1029-1035, 2002.
- Lust G, Todhunter RJ, Erb HN, Dykes NL, Williams AJ, Burton-Wurster NI, Farese JP: Comparison of three radiographic methods for diagnosis of hip dysplasia in eight-month-old dogs. J Am Vet Med Assoc 219(9):1242-1246, 2001.
- Lust G, Todhunter R.J, Erb HN, Dykes NL, Williams AJ, Burton-Wurster NI, Farese JP: Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritis. Am J Vet Res 62(11):1711-1715, 2001.
- Fubini SL, Todhunter RJ, Burton-Wurster N, Vernier-Singer M, MacLeod JN. Corticosteroids alter the differentiated phenotype of articular chondrocytes. J Orthop Res 19(4):688-695, 2001.
- Murphy DJ, Todhunter RJ, Fubini SL, Vernier-Singer M, Straubinger RK, Lust G: The effects of methylprednisolone on normal and monocyte-conditioned medium-treated articular cartilage from dogs and horses. Vet Surg 29(6):546-557, 2000.
- Sevalla K, Todhunter RJ, Vernier-Singer M, Budsberg SC: Effect of polysulfated glycosaminoglycan on DNA content and proteoglycan metabolism in normal and osteoarthritic canine articular cartilage explants. Vet Surg 29(5):407-414, 2000.
- Bertram JE, Lee DV, Case HN, Todhunter RJ: Comparison of the trotting gaits of Labrador Retrievers and Greyhounds. Am J Vet Res 61(7):832-838, 2000.
- Todhunter RJ, Acland GM, Olivier M, et al: An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Heredity 90(1):83-92, 1999.
- Farese JP, Lust G, Williams AJ, Dykes NL, Todhunter RJ: Dorsolateral subluxation of femoral heads and distraction laxity for evaluation of canine hip joints. Am J Vet Res 60:1571-1576, 1999.
- Burton-Wurster N, Farese JP, Todhunter RJ, Lust G: Site-specific variation in femoral head cartilage composition in dogs at high and low risk for development of osteoarthritis: Insights into lesion formation. Osteoarthritis Cart 7:486-497, 1999.
- Lee DV, Bertram JEA, Todhunter RJ: Acceleration and balance in trotting dogs. J Exp Biol 202(Pt 24):3565-3573, 1999.
- Todhunter RJ, Acland GM, Olivier M, Williams AJ, Vernier-Singer M, Burton-Wurster N, Farese JP, Gröhn YT, Gilbert RO, Dykes NL, Lust G: An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Hered 90(1):83-92, 1999.
- Farese JP, Todhunter RJ, Lust G et al.: Dorsolateral subluxation of hip joints measured in a weight-bearing position with radiography and computed tomography in dogs. Vet Surg 27:393-405, 1998.
- MacLeod JN, Fubini SL, Gu DN, Tetreault JW, Todhunter RJ. Effect of synovitis and corticosteroids on transcription of cartilage matrix proteins. Am J Vet Res 59(8):1021-1026, 1998.
- McNamara PS, Johnston SA, Todhunter RJ: Slow-acting, disease-modifying osteoarthritis agents. Vet Clin North Am Small Anim Pract 27(4):863-881, 1997.
- Farquhar T, Bertram J, Todhunter RJ, Burton-Wurster N, Lust G: Variations in composition of cartilage from the shoulder joints of young adult dogs at risk for developing canine hip dysplasia. J Am Vet Med Assoc 210(10):1483-1485, 1997.
- Todhunter RJ, Zachos TA, Gilbert RO, Erb HN, Williams, AJ, Burton-Wurster N, Lust G: Onset of epiphyseal mineralization and growth plate closure in radiographically normal and dysplastic Labrador retrievers. J Am Vet Med Assoc 210(10):1458-1462, 1997.
- Todhunter RJ, Fubini SL, Wootton JAM, Lust G. Effect of methylprednisolone acetate on proteoglycan and collagen metabolism of articular cartilage explants. J. Rheumatol 23(7):1207-1213, 1996.
- Farquhar T, Todhunter R, Fubini S, Burton-Wurster N, Lust G: Effect of methylprednisolone and mechanical loading on canine articular cartilage in explant culture. Osteoarthritis Cartilage 4(1):55-62, 1996.
- Todhunter RJ, Yeh L-A, Sheldon A, Grisanzio L, Walker SL, Burton-Wurster N, Lust G: Effects of stromelysin activity on proteoglycan degradation of canine articular cartilage explants. Am J Vet Res 56(9):1241-1247, 1995.
- Todhunter RJ, Lust G: Polysulfated glycosaminoglycan in the treatment of osteoarthritis. J Am Vet Med Assoc 204(8):1245-1251, 1994.
- Suess RP Jr, Trotter EJ, Konieczynski D, Todhunter RJ, Bartel DL, Flanders JA: Exposure and postoperative stability of three medial surgical approaches to the canine elbow. Vet Surg 23(2):87-93, 1994.
Book Chapters
- Todhunter RJ, Lust G. Pathogenesis of canine hip dysplasia. In: Slatter D, ed. Textbook of Small Animal Surgery, Philadelphia: WB Saunders Co, 2003, pp 2009-2019.
- Todhunter RJ, Johnston S. Osteoarthritis. In: Slatter D, ed. Textbook of Small Animal Surgery, Philadelphia: WB Saunders Co, 2003, pp 2208-2246.
featured in archived article
Teaching
teaching activities
- VTMED-5613: Small Animal Surgery Orthopedics - Spring 2013
- VTMED-6299: Research Opportunities in Veterinary Medicine - Spring 2013
- VTMED-6621: Introduction to Small Animal Orthopedics - Spring 2013
- VTMED-5613: Small Animal Surgery Orthopedics - Fall 2012
- VTMED-5613: Small Animal Surgery Orthopedics - Spring 2012
- VTMED-6299: Research Opportunities in Veterinary Medicine - Spring 2012
- VTMED-6611: Small Animal Orthopedic Surgery - Spring 2012
- VTMED-6621: Introduction to Small Animal Orthopedics - Spring 2012
- VTMED-6611: Small-Animal Surgery Orthopedic Service - Fall 2011
Background
education and training
- Ph.D. 1992
- Michigan State University, MS and Equine Residency 1980
- University of Sydney, BVSc 1976