Baines, Joel D.

member of graduate field

other Cornell affiliations

Program in Virology

research overview

- The major focus of the laboratory is to understand herpes simplex virus assembly. The work is divided into two areas. The first area of interest focuses on the process of DNA cleavage and packaging within infected cell nuclei; the process is the target of a novel class of antiviral drugs currently under development. The work is now focused on DNA binding activities relevant to DNA packaging. The approach is to identify packaging proteins that bind DNA and test the binding activities for relevance to the in vivo packaging reaction.
- A second area concerns the cell biology of HSV assembly and envelopment. Experiments have identified proteins, essential to envelopment of nucleocapsids, that alter the structure of the nucleus, presumably to allow efficient production of virions. The goal of this research is to determine how the HSV proteins alter the nuclear cytoskeleton and mediate nucleocapsid trafficking through the nucleoplasm. This should shed light not only on envelopment of nucleocapsids, but also the functions of host proteins required for maintenance of the normal nuclear architecture and trafficking of material through the nucleus in uninfected cells.

principal investigator on

CORNELL UNIVERSITY VETERINARY INVESTIGATOR PROGRAM awarded by NATL CTR FOR RESEARCH RESOURCES, NIH 2010 - 2015
NUCLEOCAPSID ENVELOPMENT HERPES SIMPLEX VIRUS-1 awarded by NATL INST OF ALLERGY & INFECTIOUS DISEASE NIH 2009 - 2014
VETERINARY STUDENT TRAINING IN BIOMEDICAL RESEARCH awarded by OFFICE OF THE DIRECTOR NIH 2009 - 2014

selected publications listing

- Yang, K. and J.D. Baines. Proline and tyrosine residues in scaffold proteins of herpes simplex virus 1 critical to the interaction with portal protein and its incorporation into capsids. J. Virol. 83:8076-8081 (Epub, March 31, 2009).
- Mou, F., EG Wills and J.D. Baines (2009). Phosphorylation of the Herpes simplex virus 1 UL31 protein by the US3 encoded kinase regulates localization of the nuclear envelopment complex and egress of nucleocapsids J. Virol. 83:5181-5191 (Epub, March 11, 2009).
- Wills, E.G., F. Mou and J.D. Baines (2009). The UL31 and UL34 gene products of herpes simplex virus 1 are required for optimal localization of viral glycoproteins D and M to the inner nuclear membrane of infected cells. J. Virol. 83:4800-4809 (Epub, March 11, 2009).
- Yang, K. and J.D. Baines (2009). The putative leucine zipper of herpes simplex virus 1 pUL6 is required for interaction with terminase subunits pUL28 and pUL15 and their incorporation into capsids. J Virol. 83:4557-4564 (E pub, February 2009).
- Wisner, T., Wright, C., Kato, A., Mou, F. Baines J.D., Roller R.J. and Johnson, D.C. (2009). Herpes simplex virus glycoprotein B that promotes fusion at the nuclear envelope is phosphorylated in a manner dependent on the viral kinase US3 that also promotes nuclear egress. J. Virol 83:3115-3126.
- Duffy, C., E. F. Mbong, and J.D. Baines. (2008, 2009). VP22 of herpes simplex virus 1 promotes viral protein synthesis late in infection and accumulation of a subset of viral mRNAs early in infection. J. Virol. 83:1009-1017 (E pub, October, 2008).

event host

Taking Advantage of Cellular Stress Responses: How Human Cytomegalovirus Deals with Stress

education and training

Ph.D. in Molecular Virology of Feline Coronaviruses 1988
D.V.M., University of Pennsylvania 1983
B.S. in Microbiology, Kansas State University 1979

VIVO: Cornell Research & Scholarship

Baines, Joel D.

Positions

Websites

Affiliations

member of graduate field

other Cornell affiliations

Research

research overview

principal investigator on

Publications

selected publications listing

Service

event host

Background

education and training