Networks
Appleton, Judith Ann
Alfred H. Caspary Professor of Immunology
Positions
- Professor, James A. Baker Institute for Animal Health, College of Veterinary Medicine
- Associate Dean, College of Veterinary Medicine, Cornell University
Websites
- Affiliations
- Research
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Affiliations
leadership role
- James A. Baker Institute for Animal Health Director 2009 -
member of graduate field
other Cornell affiliations
Research
research overview
- Roundworms, or nematodes are important causes of diseases in animals, yet relatively little is known about how they sustain themselves in the animals that they infect. Our research aims to elucidate and exploit the ways by which the host's immune response interferes with parasitism by nematodes. We are currently studying two important pathogens, Trichinella spiralis and Parelaphostrongylus tenuis. The latter organism is a significant cause of disease in sheep, goats and llamas in the Northeast. Our goals for the P. tenuis work are twofold: first, to develop an antigen detection test for use in diagnosis, and second, to design vaccines to prevent infection. Our interest in T. spiralis concerns the most fundamental question in infectious disease, specifically, how does one organism parasitize another?
principal investigator on
- EOSINOPHILS PROMOTE NEMATODE INFECTION awarded by NATL INST OF ALLERGY & INFECTIOUS DISEASE NIH 2012 - 2013
Publications
individual publications
-
academic article
- Cloning and analysis of a Trichinella pseudospiralis muscle larva secreted serine protease gene. Veterinary Parasitology. 159:268-271. 2009
- Immunity to Trichinella spiralis muscle infection. Veterinary Parasitology. 159:245-248. 2009
- Eosinophil deficiency compromises parasite survival in chronic nematode infection. Journal of Immunology. 182:1577-1583. 2009
- Expulsion of secondary Trichinella spiralis infection in rats occurs independently of mucosal mast cell release of mast cell protease II. Journal of Immunology. 183:5816-5822. 2009
- Divergent metabolic adaptations to intestinal parasitic nematode infection in mice susceptible or resistant to obesity. Gastroenterology. 133:1979-1988. 2007
- Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T cells, and TGF-beta(1). Journal of Immunology. 178:1039-1047. 2007
- Protein glycosylation in Parelaphostrongylus tenuis--first description of the Galalpha1-3Gal sequence in a nematode. Glycobiology. 16:854-862. 2006
- Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development. Infection and Immunity. 74:1941-1943. 2006
- Cathepsin B Homologue at the Interface between a Parasitic Nematode and Its Intermediate Host. Infection and Immunity. 74:1297-1304. 2006
- Application of monoclonal antibodies in functional and comparative investigations of heavy-chain immunoglobulins in new world camelids. Clinical and Diagnostic Laboratory Immunology. 12:380-386. 2005
- Interleukin-10 Limits Local and Body Cavity Inflammation during Infection with Muscle-Stage Trichinella spiralis. Infection and Immunity. 72:3129-3137. 2004
- IL-10 prevents liver necrosis during murine infection with Trichinella spiralis. Journal of Immunology. 171:3142-3147. 2003
- A putative serine protease among the excretory-secretory glycoproteins of L1 Trichinella spiralis. Molecular and Biochemical Parasitology. 122:149-160. 2002
- An aspartyl protease inhibitor orthologue expressed by Parelaphostrongylus tenuis is immunogenic in an atypical host. Clinical and Diagnostic Laboratory Immunology. 9:763-770. 2002
- Molting, ecdysis, and reproduction of Trichinella spiralis are supported in vitro by intestinal epithelial cells. Infection and Immunity. 70:1853-1859. 2002
- A pivotal role for glycans at the interface between Trichinella spiralis and its host. Veterinary Parasitology. 101:249-260. 2001
- Invasion of epithelial cells by Trichinella spiralis: in vitro observations. Parasite. 8:S48-S50. 2001
- Phosphorylcholine-containing N-glycans of Trichinella spiralis: identification of multiantennary lacdiNAc structures. Glycobiology. 10:941-950. 2000
- Larvae-induced plasma membrane wounds and glycoprotein deposition are insufficient for Trichinella spiralis invasion of epithelial cells. Molecular and Biochemical Parasitology. 107:207-218. 2000
- Dominance of immunoglobulin G2c in the antiphosphorylcholine response of rats infected with Trichinella spiralis. Infection and Immunity. 67:4661-4667. 1999
- Terminal beta-linked tyvelose creates unique epitopes in Trichinella spiralis glycan antigens. Glycobiology. 7:383-390. 1997
- Workshop on a detailed characterization of Trichinella spiralis antigens: a platform for future studies on antigens and antibodies to this parasite. Parasite Immunology. 18:273-284. 1996
- Glycans as targets for monoclonal antibodies that protect rats against Trichinella spiralis. Glycobiology. 4:585-592. 1994
- Novel tyvelose-containing tri- and tetra-antennary N-glycans in the immunodominant antigens of the intracellular parasite Trichinella spiralis. Glycobiology. 4:593-603. 1994
- Molecular analysis of antigens targeted by protective antibodies in rapid expulsion of Trichinella spiralis. Molecular and Biochemical Parasitology. 65:201-211. 1994
- Trichinella spiralis: the effect of specific antibody on muscle larvae in the small intestines of weaned rats. Experimental Parasitology. 76:394-400. 1993
- Identification of potential antigenic targets for rapid expulsion of Trichinella spiralis. Molecular and Biochemical Parasitology. 58:53-62. 1993
- Rapid expulsion of Trichinella spiralis in adult rats mediated by monoclonal antibodies of distinct IgG isotypes. Immunology. 75:520-527. 1992
- Intestinal mucus entrapment of Trichinella spiralis larvae induced by specific antibodies. Immunology. 74:546-551. 1991
- The role of mucus in antibody-mediated rapid expulsion of Trichinella spiralis in suckling rats. Immunology. 70:126-132. 1990
- Rapid expulsion of Trichinella spiralis in suckling rats: mediation by monoclonal antibodies. Immunology. 65:487-492. 1988
- Characterization of the immune mediator of rapid expulsion of Trichinella spiralis in suckling rats. Immunology. 62:477-484. 1987
- Life-phase specific induction and expression of rapid expulsion in rats suckling Trichinella spiralis-infected dams. Immunology. 55:225-232. 1985
- Rapid expulsion of Trichinella spiralis in suckling rats. Science. 226:70-72. 1984
- The role of the antibody Fc region in rapid expulsion of Trichinella spiralis in suckling rats
Teaching
Background
education and training
- Ph.D. in Microbiology, University of Georgia 1980
- M.S. in Microbiology, University of Georgia 1977
- B.S. in Microbiology, Indiana University 1975