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Goldberg, Michael Lewis
Cornell Faculty Member
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Research Areas
- biochemistry
- bioinformatics
- biomedical sciences
- cell biology
- genetics
- molecular genetics
- new life sciences
- proteomics
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Affiliations
Research
research overview
- The research in my laboratory is directed toward an increase ion our understanding of the molecular mechanisms ensuring accurate chromosome segregation and other chromosome behaviors. These issues are of considerable potential importance to human health because mistakes in chromosome segregation are implicated in the genesis of many inherited syndromes and of cancer. Our analysis of these mutants should continue to uncover new genes that play important conserved roles in apportioning chromosomes and other chromosomal behaviors during cell division, but that could not be found in other ways.
principal investigator on
- GREATWALL KINASE AND THE MITOTIC CONTROL OF PHOSPHATASE ACTIVITY awarded by NATL INST OF HEALTH DHHS 2010 - 2013
area(s) of concentration/expertise
keywords
- Drosophila
- Xenopus
- cell cycle
- cell division
- chromosome condensation
- chromosome segregation
- meiosis
- mitosis
submitted impact statement
Publications
individual publications
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academic article
- Bypassing the Greatwall-Endosulfine pathway: Plasticity of a pivotal cell-cycle regulatory module in Drosophila melanogaster and Caenorhabditis elegans. Genetics. 191:1181-1197. 2012
- Determinants for Activation of the Atypical AGC Kinase Greatwall During M Phase Entry.. Molecular and Cellular Biology. 32:1337-53. 2012
- The Drosophila RZZ complex: Roles in membrane trafficking and cytokinesis. Journal of Cell Science. 125:4014-4025. 2012
- Regulation of Greatwall kinase during Xenopus oocyte maturation. Molecular Biology of the Cell. 22:2157-2164. 2011
- A novel role for greatwall kinase in recovery from DNA damage.. Cell Cycle. 9:4364-4369. 2010
- Greatwall kinase protects mitotic phosphosites from barbarian phosphatases.. Proceedings of the National Academy of Sciences (PNAS). 107:12409-12410. 2010
- Roles of the Drosophila NudE protein in kinetochore function and centrosome migration. Journal of Cell Science. 122:1747-1758. 2009
- The M phase kinase Greatwall (Gwl) promotes inactivation of PP2A/B55delta, a phosphatase directed against CDK phosphosites. Molecular Biology of the Cell. 20:4777-4789. 2009
- Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. PLOS Genetics. 4. 2008
- Roles of Greatwall kinase in the regulation of Cdc25 phosphatase. Molecular Biology of the Cell. 19:1317-1327. 2008
- Developmental and cell cycle progression defects in Drosophila hybrid males. Genetics. 177:2233-2241. 2007
- Mitch – a rapidly evolving component of the Ndc80 kinetochore complex required for correct chromosome segregation in Drosophila. Journal of Cell Science. 120:3522-3533. 2007
- The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Development. 134:2183-2193. 2007
- Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts.. Mol. Cell. 22:83-91. 2006
- The Drosophila Calcipressin Sarah Is Required for Several Aspects of Egg Activation. Current Biology. 16:1441-1446. 2006
- The Drosophila Bub3 protein is required for the mitotic checkpoint and for normal accumulation of cyclins during G2 and early stages of mitosis. Journal of Cell Science. 118:187-198. 2005
- The putative Drosophila transcription factor woc is required to prevent telomeric fusions. Mol. Cell. 20:821-831. 2005
- Feo, the Drosophila homolog of PRC1, is required for central-spindle formation and cytokinesis. Current Biology. 14:1569-75. 2004
- Greatwall kinase: A nuclear protein required for proper chromosome condensation and mitotic progression in Drosophila. Journal of Cellular Biology. 164:487-492. 2004
- Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. Journal of Biological Chemistry. 279:54590-54598. 2004
- Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Research. 64:2998-3001. 2004
- Two putative acetyltransferases, San and Deco, are required for establishing sister chromatid cohesion in Drosophila. Current Biology. 13:2025-2036. 2003
- Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions. Molecular and Cellular Biology. 14:1379-1391. 2003
- Phenotypic characterization of Drosophila ida mutants: defining the role of APC5 in cell cycle. J Cell Sci. 115:949-961. 2002
- Another Thing They Never Taught You in Grad School: How to Organize a Scientific Meeting. . Science's Next Wave, http://nextwave.sciencemag.org/cgi/content/full/2001/05/10/2.. online. 2001
- Cofilin/ADF is required for cell motility during the development of the Drosophila ovary. Nature Cell Biol. 3:204-209. 2001
- Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A. J Cell Sci. 114:3529-3542. 2001
- The zw10 and rough deal gene products are in a large, evolutionarily conserved complex targeted to the kinetochore. J Cell Sci. 114:3103-3114. 2001
- Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Genetics. 154:1693-1710. 2000
- Human ZW10 and ROD are mitotic checkpoint proteins that bind to the kinetochore. Nature Cell Biol. 2:944-947. 2000
- Hzwint-1, a novel human kinetochore component that interacts with HZW10. J Cell Sci. 113:1939-1950. 2000
- ZW10 is required for poleward chromosome motion in Drosophila spermatocytes. Nature Cell Biol. 2:948-952. 2000
- Interactions between Drosophila nuclear envelope proteins lamin otefin and YA. Molecular and Cellular Biology. 18:4315-4323. 1998
- Ablation of papillar cell function in Brassica flowers results in the loss of stigma receptivity to pollination. Plant Cell. 5:263-275. 1993
- Amino acid sequences of glycoproteins encoded by three alleles at the S locus of Brassica oleracea. Nature. 326:617-619. 1987
- A cDNA clone encoding an S-locus specific glycoprotein from Brassica oleracea. Nature. 318:263-267. 1985
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article
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book
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chapter
- Harnessing the power of Drosophila genetics. Methods in Cell Biology Volume 4. Drosophila melanogaster: Practical uses in cell and molecular biology. 34-80. 1994
Teaching
teaching overview
- My major focus in teaching is undergraduate instruction in genetics. I have taught Introductory Genetics (BioGD281) for many years, and am an author of the textbook used in this course and in many universities around the world. For the last several years, I have been the instructor of BioGD282 (Human Genetics). I also play a role in the instruction of graduate students, particularly in introducing them to resources on the Internet that are useful for research in genetics and molecular biology.
teaching activities
Service
Background
education and training
- Ph.D. in Biochemistry, Stanford University 1978
- B.S. in Molecular Biochemistry & Biophysics, Yale University 1973
awards and honors
- Fellow of the Fondazione Cenci Bolognetti, Rome, Italy, 2000
- Member, NIH Genetics Study Section 10/95-10/99, 1995
- Fogarty Senior International Fellowship, Ad hoc Study Section Service (Genetics (twice); BIOL-2 (once); AREA (once); NDT (once)), 1989
- Helen Hay Whitney Postdoctoral Fellowship, 1979-1981, 1979
- National Institutes of Health Training Grant, 1976-1978, 1976
- National Science Foundation Graduate Fellowship, 1973-1976, 1973
- National Merit Scholar, 1969-1973, 1969
Other
college
- CALS
research keyword
- Drosophila
- Xenopus
- cell cycle
- cell division
- chromosome condensation
- chromosome segregation
- meiosis
- mitosis
name prefix
- Professor