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Vogt, Volker M
Cornell Faculty Member
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Positions
BS Chemistry, CalTech, 1964
PhD Biochemistry and Molecular Biology 1971
Research Areas
- biochemistry
- biomedical sciences
- cell biology
- genetics
- microbiology
- molecular biology
- molecular genetics
Websites
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- Research
- Publications
- Teaching
- Service
- Background
- Other
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Affiliations
administrative responsibilities
- Director of Graduate Studies for Biochemistry, Molecular, and Cell Biology
member of graduate field
other Cornell affiliations
advisory group member
Research
research overview
- We study the assembly of retroviruses, using primarily Rous sarcoma virus, the prototypic avian retrovirus, as a model system. We also study some of the proteins involved in HIV assembly.
research activities
principal investigator on
- AVIAN RETROVIRUS STRUCTURE AND ASSEMBLY awarded by NATL INST OF HEALTH DHHS 2007 - 2013
area(s) of concentration/expertise
keywords
- HIV
- avian retrovirus
- retrovirus
- virology
- virus assembly
submitted impact statement
Publications
individual publications
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academic article
- HIV-1 Gag protein can sense the cholesterol and acyl chain environment in model membranes.. Proceedings of the National Academy of Sciences of the United States of America. 109:18761-18766. 2012
- Rous sarcoma virus Gag has no specific requirement for phosphatidylinositol-(4,5)-bisphosphate for plasma membrane association in vivo or for liposome interaction in vitro. Journal of Virology. 85:10851-10860. 2011
- An LYPSL late domain in the Gag protein contributes to the efficient release and replication of Rous sarcoma virus. Journal of Virology. 84:6276-6287. 2010
- Conserved and variable features of Gag structure and arrangement in immature retrovirus particles. Journal of Virology. 84:11729-11736. 2010
- NMR relaxation studies of an RNA-binding segment of the Rous sarcoma virus Gag polyprotein in free and bound states: a model for autoinhibition of assembly. Biochemistry. 49:4006-4017. 2010
- Foreign glycoproteins can be actively recruited to virus assembly sites during pseudotyping. . Journal of Virology. 83:4060-4067. 2009
- A molecular switch required for retrovirus assembly participates in the hexagonal immature lattice.. EMBO Journal. 27:1411-1420. 2008
- Mutations in the spacer peptide and adjoining sequences in Rous sarcoma virus Gag lead to tubular budding.. Journal of Virology. 82:6788-6797. 2008
- Electrostatic interactions drive membrane association of the HIV-1 Gag MA domain. Journal of Virology. 81:6434-6445. 2007
- Mutations that mimic phosphorylation of the HIV-1 matrix protein do not perturb the myristyl switch. Protein Science. 16:1793-1797. 2007
- Solution structure of the Rous sarcoma virus nucleocapsid protein: muPsi RNA packaging signal complex. Journal of Molecular Biology. 365:453-467. 2007
- Cryo-electron microscopy reveals conserved and divergent features of Gag packing in immature particles of Rous sarcoma virus and human immunodeficiency virus. Journal of Molecular Biology. 355:157-168. 2006
- Biochemical chracterization of Rous sarcoma virus MA protein interaction with membranes. Journal of Virology. 79:6227-6238. 2005
- The C-terminal half of TSG101 blocks Rous sarcoma virus budding and sequesters Gag into unique nonendosomal structures. Journal of Virology. 79:3775-3786. 2005
- The retroviral CA domain dictates virion size, morphology and co-assembly of Gag into virus-like particles. Journal of Virology. 79:13463-13472. 2005
- Visualization of retrovirus budding with correlated light and electron microscopy. Proceedings at the National Academy of Science USA. 102:15453-15458. 2005
- Dimeric Rous sarcoma virus capsid protein structure relevant to immature Gag assembly. Journal of Molecular Biology. 335:275-282. 2004
- Formation of Gag dimers in the assembly of Rous sarcoma virus particles in vitro. Journal of Virology. 78:52-60. 2004
- The stoichiometry of Gag protein in HIV. Nature Structural and Molecular Biology. 11:672-675. 2004
- Direct measurement of GagG��Gag interaction during retrovirus assembly with FRET and fluorescence correlation spectroscopy. Journal of Cell Biology. 162:1233-1244. 2003
- Characterization of the protease of a fish retrovirus, walleye dermal sarcoma virus. Journal of Virology. 76:4341-4349. 2002
- Nucleic acid-independent retrovirus assembly can be driven by dimerization. Journal of Virology. 76:11177-11185. 2002
- Rous sarcoma virus Gag protein – oligonucleotide interaction suggests a critical role for protein dimer formation in assembly. Journal of Virology. 76:5452-5462. 2002
- Walleye dermal sarcoma virus reverse transcriptase is temperature sensitive.. Journal of General Virology. 83:1361-1365. 2002
- 1H, 15N and 13C chemical shift assignments of a monomeric N-terminal deletion mutant of the Rous sarcoma virus protease. Journal of Biomolecular NMR. 19:279-280. 2001
- Characterization of Rous sarcoma virus Gag particles assembled in vitro. Journal of Virology. 75:2753-2764. 2001
- Importance of the N-terminus of Rous sarcoma virus protease for structure and enzymatic function. Journal of Virology. 75:4761-4770. 2001
- Organization of mature Rous sarcoma virus as studied by cryo-electron microscopy. Journal of Structural Biology. 136:67-80. 2001
- The PR domain of Rous sarcoma virus (RSV) Gag causes an assembly/budding defect in insect cells. Journal of Virology. 75:4407-4412. 2001
- Expression of the Naegleria intron endonuclease is dependent on a functional group I self-cleaving ribozyme. RNA. 6:616-627. 2000
- Functional -fragment of -galactosidase can be expressed from the mobile group I intron PpLSU3 embedded in yeast pre-ribosomal RNA derived from the chromosomal rDNA locus. Nucleic Acids Research. 28:1428-1438. 2000
- Role of the Rous sarcoma virus p10 domain in shape-determination of Gag virus-like particles assembled in vitro and within E. coli. Journal of Virology. 74:10260-10268. 2000
- Structure and self-association of the Rous sarcom virus capsid protein. Structure. 8:617-628. 2000
- Mass determination of Rous sarcoma virus virions by scanning transmission electron microscopy (STEM). Journal of Virology. 73:7050-7055. 1999
- Genetic determinants of Rous sarcoma virus particle size. Journal of Virology. 72:564-577. 1998
- I-PpoI, the endonuclease encoded by the group I intron PpLSU3, is expressed from an RNA polymerase I transcript. Molecular and Cellular Biology. 18:5809-5817. 1998
- In vivo selection of Rous sarcoma virus mutants with randomized sequences in the packaging signal. Journal of Virology. 72:8073-8082. 1998
- Analysis of cleavage site mutations between the NC and PR Gag domains of Rous saroma virus. Journal of Virology. 71:444-450. 1997
- Cryo-electron microscopy reveals ordered domains in the immature HIV-1 particle. Current Biology. 7:729-738. 1997
- Crystals of Rous sarcoma virus capsid protein show a helical arrangement of protein subunits. Virology. 238:79-84. 1997
- In vitro assembly of virus-like particles with Rous sarcoma virus Gag deletion mutants: Identification of the p10 domain as a morphological determinant in the formation of spherical particles. Journal of Virology. 71:4425-4435. 1997
- Naegleria nucleolar introns contain two group I ribozymes with different functions in RNA splicing and processing. RNA. 3:710-720. 1997
- Analysis of Rous sarcoma virus Gag proteins by mass spectrometry indicates trimming by host exopeptidase. Journal of Virology. 70:3313-3318. 1996
- Proteolytic activity of purified avian sarcoma and leukemia virus NC-PR protein expressed in E. coli. Virology. 221:335-345. 1996
- Differential proteolytic processing leads to multiple forms of the CA protein of avian sarcoma and leukemia viruses. Journal of Virology. 69:6430-6438. 1995
- In situ hybridization and immunohistochemical study of walleye dermal sarcoma virus (WDSV) nucleic acids and proteins in spontaneous sarcomas of adult walleyes (Stizostedion vitreum). Veterinary Pathology. 32:162-172. 1995
- Nucleotide sequence and protein analysis of a complex piscine retrovirus, walleye dermal sarcoma virus. Journal of Virology. 69:5320-5331. 1995
- Proteolytic processing of particle-associated retroviral polyproteins by homologous and heterologous viral proteinases. Eur J Biochem. 228:191-198. 1995
- Self assembly in vitro of purified CA-NC proteins from Rous sarcoma virus and human immunodeficiency virus-1. Journal of Virology. 69:6487-6497. 1995
- Two group I ribozymes with different functions in a nuclear rDNA intron. EMBO Journal. 14:4558-4568. 1995
- An intron in the nuclear ribosomal DNA of Didymium iridis codes for a group I ribozyme and a novel ribozyme that cooperate in self splicing. Cell. 76:725-734. 1994
- Efficiency and selectivity of RNA packaging by Rous sarcoma virus Gag deletion mutants. Journal of Virology. 68:5969-5981. 1994
- Proteolytic cleavage at the Gag-Pol junction in avian leukosis viruses: differences in vitro and in vivo. Virology. 204:45-59. 1994
- A nuclear group I intron from Physarum polycephalum can insert itself and cause point mutations in the nuclear ribosomal DNA of Saccharomyces cerevisiae. Molecular and Cellular Biology. 13:1023-1033. 1993
- Interaction of the intron-encoded mobility endonuclease I-PpoI with its target site. Molecular and Cellular Biology. 13:7531-7539. 1993
- Reverse transcriptase and protease activities of avian leukosis virus Gag-Pol fusion proteins expressed in insect cells. Journal of Virology. 67:7582-7596. 1993
- Characterization of the self-splicing products of a mobile intron from the nuclear rDNA of Physarum polycephalum. Nucleic Acids Research. 20:5899-5906. 1992
- Processing of avian retroviral Gag polyprotein precursors is blocked by a mutation in the NC-PR cleavage site. Journal of Virology. 66:1781-1785. 1992
- Proteolysis in the maturation of avian retroviruses does not require calcium. Virology. 189:771-774. 1992
- Purification of a telomere-binding protein from Physarum polycephalum. Biochim Biophys Acta. 1171:162-166. 1992
- Characterization of a telomere-binding protein from Physarum polycephalum. Molecular and Cellular Biology. 11:2282-2290. 1991
- Trans-acting viral protease is necessary and sufficient for activation of avian leukosis virus reverse transcriptase. Journal of Virology. 65:6218-6231. 1991
- Characterization of I-Ppo, an intron-encoded endonuclease that mediates homing of a group I intron in the rDNA of Physarum polycephalum. Molecular and Cellular Biology. 10:33886-3396. 1990
- Properties of avian retrovirus particles defective in viral protease. Journal of Virology. 64:5076-5092. 1990
- RNA binding properties of MA protein (p19gag) of avian sarcoma and leukemia viruses. Journal of Virology. 64:847-855. 1990
- Ubiquitin in avian sarcoma and leukemia virus particles. Virology. 176:633-637. 1990
- Mobile introns: definition of terms and recommended nomenclature. Gene. 82:115-118. 1989
- Standardized and simplified nomenclature for proteins common to all retroviruses. Journal of Virology. 62:1808-1890. 1989
- mobile group I intron in the nuclear rDNA of Physarum polycephalum. Cell. 56:443-454. 1989
- A simple method for immunoaffinity purification of non-denatured avian sarcoma and leukemia virus Gag-containing proteins. Virology. 160:494-497. 1987
- Characterization of ribosomal RNA synthesis in a gene dosage mutant: the relationship of topoisomerase I and chromatin structure to transcriptional activity. Journal of Cell Biology. 105:1501-1513. 1987
- Structure and processing of the p2 region of avian sarcoma and leukemia virus Gag precursor polyproteins. Journal of Virology. 58:50-58. 1986
- Primary structures of p19 species of avian sarcoma and leukemia viruses. Journal of Virology. 56:31-39. 1985
- The primary structure of p19 species of avian sarcoma and leukemia viruses. Journal of Virology. 56:31-39. 1985
- The ribosomal RNA gene cluster in aneuploid chickens: evidence for increased gene dosage and regulation of gene expression. Journal of Cell Biology. 101:1749-1756. 1985
- Fine structure analyses of lipid-protein and protein-protein interactions of Gag protein p19 of avian sarcoma and leukemia viruses by cyanogen bromide mapping. Journal of Virology. 52:145-153. 1984
- Amino terminal amino acid sequence of p10, the fifth Gag polypeptide of avian sarcoma and leukemia viruses. Journal of Virology. 45:885-888. 1983
- H-protein, a minor protein of TMV virions, contains sequences of the viral coat protein. Virology. 126:429-448. 1983
- Inheritance of extrachromosomal rDNA in Physarum. Molecular and Cellular Biology. 3:635-642. 1983
- Localization and DNA sequences around the initiation site of ribosomal RNA transcription in Physarum polycephalum. Nucleic Acids Research. 11:8519-8532. 1983
- Purification and properties of p10, a fifth major viral Gag protein from avian sarcoma and leukemia viruses. Journal of Virology. 45:648-658. 1983
- Accessibility of ribosomal genes to trimethyl psoralen in nuclei of Physarum polycephalum. Molecular and Cellular Biology. 2:211-220. 1982
- Avian sarcoma virus gag precursor polypeptide Pr76 is not cleaved in mammalian cells. Journal of Virology. 44:725-730. 1982
- Structure of the central spacer region of extrachromosomal ribosomal DNA in Physarum polycephalum. J Mol Biol. 159:359-381. 1982
- Chemical cross-linking of proteins in avian sarcoma and leukemia viruses. Virology. 102:205-210. 1980
- Identification of retrovirus matrix proteins by lipid-protein cross-linking. J Mol Biol. 131:819-839. 1979
- In vitro cleavage of avian retrovirus Gag proteins by viral protease p15. Virology. 98:154-167. 1979
- The NH2-terminal sequence of the avian oncovirus Gag precursor polyprotein (Pr76gag). Virology. 91:432-433. 1978
- The biosynthesis of oncovirus proteins. Biochim Biophys Acta (Cancer Reviews). 473:187-239. 1978
- Replication of ribosomal DNA in Physarum. Eur J Biochem. 80:557-566. 1977
- Repeated structure of chromatin in mitotic nuclei of Physarum. FEBS Letters. 64:190-192. 1976
- Structure of ribosomal DNA in Physarum polycephalum. J Mol Biol. 106:567-587. 1976
- Generation of avian myeloblastosis virus structural proteins by proteolytic cleavage of a precursor polypeptide. J Mol Biol. 96:471-493. 1975
- Characterization of the single-stranded specific nuclease S1 activity on double-stranded supercoiled polyoma DNA. Eur J Biochem. 43:591-600. 1974
- Identification of a large polypeptide precursor of avian oncornavirus proteins. Proceedings at the National Academy of Science USA. 70:1734-1738. 1973
- Purification and further properties of single-stranded specific nuclease from Aspergillus oryzae. Europ J Biochem. 33:192-200. 1973
- Purification and properties of an aminopeptidase of E. coli. J Biol Chem. 245:4760-4769. 1970
- Breaks in DNA stimulate transcription by core RNA polymerase. Nature. 223:854-855. 1969
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booksection
- Proteolytic processing and particle maturation. Vol. 214. 1996
-
chapter
- Retroviral virions and their genomes. Retroviruses. 1997
- Insertion elements in ribosomal DNA. Ribosomal RNA: Structure, Evolution, Gene Expression, and Function in Protein Synthesis. 1996
-
conference paper
- Synthesis of avian RNA tumor virus structural proteins. Cold Spring Harbor Symposium of Quantitative Biology. 1067-1075. 1974
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document part
presentations
Teaching
teaching overview
- I teach the upper division course BIOBM 432 (Survey of Cell Biology), a spring course which enrolls about 90 students, mostly undergraduate juniors and seniors with a sprinkling of PhD students. This is a 3 credit course (42 lecture hours/semester; two evening prelims plus a final exam, biweekly quizzes in class, and two 1000 word papers. The course has one assigned TA. This course is required for the Molecular and Cell program of study in the Biology major.
teaching activities
- BIOMG-4320: Survey of Cell Biology - Spring 2013
- BIOMG-4330: Research Papers in Cell Biology - Spring 2013
- BIOMG-8330: Research Seminar in Biochemistry - Spring 2013
- BIOMG-8300: Biochemistry Seminar - Fall 2012
- BIOMG-8330: Research Seminar in Biochemistry - Fall 2012
- BIOMG-4320: Survey of Cell Biology - Spring 2012
- BIOMG-8330: Research Seminar in Biochemistry - Spring 2012
- BIOMG-8300: Biochemistry Seminar - Fall 2011
- BIOMG-8330: Research Seminar in Biochemistry - Fall 2011
Service
service to the profession
reviewer or editor for
- AIDS and Related Research study section
- AIDS and Related Research study section
- Developmental Therapeutics (NCI) AIDS Review Group
- Experimental Virology study section
- Experimental Virology study section
- HIV Drug Resistant Program Review
- Journal of Virology
- Virology A study section
- Virology study section
- special emphasis panel (NIH) 7/09; ad hoc NIH Board of Scientific Counselors 12/09
event host
Background
education and training
- Ph.D. in Biochemistry and Molecular Biology, Harvard 1971
- B.S. in Chemistry, California Institute of Technology 1964
awards and honors
Other
college
- CALS
research keyword
- HIV
- avian retrovirus
- retrovirus
- virology
- virus assembly
name prefix
- Professor