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Wang, Michelle D
Professor and Howard Hughes Medical Institute Investigator
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Positions
- Professor, Physics (PHYS), College of Arts and Sciences
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Affiliations
Research
research overview
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Professor Michelle Wang's research interests compromises:
- single molecule mechanical manipulations of biological molecules
- high-resolution optical trapping and detection
- single molecule fluorescence imaging and detection
- nanofabrication
- molecular motor mechanisms
- biopolymer kinetics and dynamics
- protein-DNA interactions (especially those involved in gene expression)
- genomics
- modeling of diffusion, kinetics, and dynamics of biomolecules
principal investigator on
- HOWARD HUGHES MEDICAL INSTITUTE INVESTIGATOR awarded by HOWARD HUGHES MEDICAL INST 2008 - 2013
- TORSIONAL REGULATION OF TRANSCRIPTION awarded by NATL SCIENCE FOUNDATION 2008 - 2013
- TRAINING IN MOLECULAR PHYSICS OF BIOLOGICAL SYSTEMS awarded by NATL INST OF GENERAL MEDICAL SCIENCES, NIH 2012 - 2017
Publications
individual publications
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academic article
- Discontinuities at the DNA supercoiling transition. Physical Review E. 80. 2009
- High-resolution dynamic mapping of histone-DNA interactions in a nucleosome. Nature Structural and Molecular Biology. 16:124-129. 2009
- Abrupt Buckling Transition Observed during the Plectoneme Formation of Individual DNA Molecules. Physical Review Letters. 100. 2008
- Probing SWI/SNF remodeling of the nucleosome by unzipping single DNA molecules. Nature Structural and Molecular Biology. 6:549-54. 2006
- Detection of high affinity mismatch binding and sliding clamp modes for the MSH2-MSH6 mismatch recognition complex by single-molecule unzipping force analysis. Molecular Cell. 20:771-781. 2005
- Specific Contributions of Histone Tails and their Acetylation to the Mechanical Stability of Nucleosomes. Journal of Molecular Biology. 346:135-146. 2005
- Molecular mechanism of transcription inhibition by Peptide antibiotic microcin j25. Molecular Cell. 14:753-762. 2004
- Mechanical disruption of individual nucleosomes reveals a reversible multistage release of DNA. Proceedings at the National Academy of Science USA. 99:1960-65. 2002
- Single molecule analysis of RNA polymerase elongation reveals uniform kinetic behavior. Proceedings at the National Academy of Science USA. 99:13538-43. 2002
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article
- Imaging the impact on cuprate superconductivity of varying the interatomic distances within individual crystal unit cells. Proceedings of the National Academy of Sciences (PNAS). 105:3203-3208. 2008
- Imaging the impact on cuprate superconductivity of varying the interatomic distances within individual crystal unit cells. Proceedings of the National Academy of Sciences (PNAS). 105:3203-3208. 2008
- Evolution of the electronic excitation spectrum with strongly diminishing hole density in superconducting Bi2Sr2CaCu2O8+δ. Nature Physics. 4:319-326. 2008
- Interplay of electron–lattice interactions and superconductivity in Bi2Sr2CaCu2O8+δ. Nature. 309:546-550. 2006
selected publications listing
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2008 Abrupt Buckling Transition Observed during the Plectoneme Formation of Individual DNA Molecules.
S. Forth, C. Deufel, M.Y. Sheinin, B. Daniels, J.P. Sethna, and M.D. Wang.
Physical Review Letters 100:148301 (2008) (Full Text PDF ).
Kinetic modeling of transcription elongation.
L. Bai, A. Shundrovsky, and M.D. Wang.
In "RNA polymerases as molecular motors" by the Royal Society of Chemistry in press (2008).
Single molecule studies of RNA polymerase transcription.
A. Shundrovsky, L. Bai, T.J. Santangelo, and M.D. Wang.
In "Escherichia coli and Salmonella typhimurium EcoSal : Cellular and Molecular Biology", eds. I. Artsitmovitch (2008).
2007 Single molecule studies reveal dynamics of DNA unwinding by the ring-shaped T7 helicase.
D.S. Johnson, L. Bai, B.Y. Smith, S.S. Patel, and M.D. Wang.
Cell 129:1299-1309 (2007) (Full Text PDF ).
- Need for Speed: Mechanical Regulation of a Replicative Helicase
- Cornell researchers determine how an enzyme plays a key role in gene copying
Nanofabricated quartz cylinders for angular optical trapping: torque detection during DNA supercoiling.
C. Deufel, S. Forth, C.R. Simmons, S. Dejgosha, and M.D. Wang.
Nature Methods 4:223-5 (2007) (Full Text PDF ).
Mechano-chemical kinetics of transcription elongation.
L. Bai, R.M. Fulbright, & M.D. Wang.
Physical Review Letters 98:068103 (2007) (Full Text PDF ).
2006 Probing SWI/SNF remodeling of the nucleosome by unzipping single DNA molecules.
A. Shundrovsky, C. L. Smith, J.T. Lis, C.L. Peterson, and M.D. Wang.
Nature Structural and Molecular Biology 13:549-54 (2006) (Full Text PDF ).
Single-molecule analysis of RNA polymerase transcription.
L. Bai, T.J. Santangelo, and M.D. Wang.
Annual Review of Biophysics and Biomolecular Structure 35:343�60 (2006) (Full Text PDF ).
Detection of forces and displacements along the axial direction in an optical trap.
C. Deufel and M.D. Wang.
Biophysical Journal 90:657-67 (2006) (Full Text PDF ).
2005 Detection of high affinity mismatch binding and sliding clamp modes for the MSH2-MSH6 mismatch recognition complex by single-molecule unzipping force analysis.
J. Jiang, L. Bai, J. Surtees, Z. Gemici, M.D. Wang, and E. Alani.
Molecular Cell 20:771-81 (2005) (Full Text PDF ).
Functional hydrogel surfaces: binding kinesin-based molecular motor proteins to selected patterned sites.
T. Yu, Q. Wang, D.S. Johnson, M.D. Wang, and C.K. Ober.
Advanced Functional Materials 15: 1303-1309 (2005) (Full Text PDF ).
Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes.
B. Brower-Toland, D.A. Wacker, R.M. Fulbright, J.T. Lis, W.L. Kraus, and M.D. Wang.
Journal of Molecular Biology 346:135-146 (2005) (Full Text PDF ).
2004 A single molecule technique to study sequence-dependent transcription pausing.
A. Shundrovsky, T.J. Santangelo, J.W. Roberts, and M.D. Wang.
Biophysical Journal 87:3945-53 (2004) (Full Text PDF ).
Sequence-dependent kinetic model for RNA polymerase elongation.
L. Bai, A. Shundrovsky, and M.D. Wang.
Journal of Molecular Biology 344:335-349 (2004) (Full Text PDF ).
The molecular mechanism of transcription inhibition by Microcin J25.
K. Adelman, J. Yuzenkova, A. La Porta, J.T. Lis, S. Brukhov, M.D. Wang, and K.V. Severinov.
Molecular Cell 14:753-762 (2004) (Full Text PDF ).
Optical torque wrench: angular trapping, rotation and torque detection using quartz microparticles.
A. La Porta and M.D. Wang.
Physical Review Letters 92:190801 (2004) (Full Text PDF ).
Twisty Tweezers - Physical Review Focus Article on the Angular Optical Trap
Use of optical trapping techniques to study single nucleosome dynamics.
B. Brower-Toland, and M.D. Wang.
Methods in Enzymology: Chromatin and Chromatin Remodeling Enzymes 376:62-72 (2004). (Full Text PDF ).
2003 Dynamic force spectroscopy of protein-DNA interactions by unzipping DNA double helix.
S.J. Koch, and M.D. Wang.
Physical Review Letters 91:028103 (2003) (Full Text PDF ).
Biophysicists 'unzip' DNA technique that could aid drug development - Need for Speed: Mechanical Regulation of a Replicative Helicase
-
2008 Abrupt Buckling Transition Observed during the Plectoneme Formation of Individual DNA Molecules.
S. Forth, C. Deufel, M.Y. Sheinin, B. Daniels, J.P. Sethna, and M.D. Wang.
Physical Review Letters 100:148301 (2008) (Full Text PDF ).
Kinetic modeling of transcription elongation.
L. Bai, A. Shundrovsky, and M.D. Wang.
In "RNA polymerases as molecular motors" by the Royal Society of Chemistry in press (2008).
Single molecule studies of RNA polymerase transcription.
A. Shundrovsky, L. Bai, T.J. Santangelo, and M.D. Wang.
In "Escherichia coli and Salmonella typhimurium EcoSal : Cellular and Molecular Biology", eds. I. Artsitmovitch (2008).
2007 Single molecule studies reveal dynamics of DNA unwinding by the ring-shaped T7 helicase.
D.S. Johnson, L. Bai, B.Y. Smith, S.S. Patel, and M.D. Wang.
Cell 129:1299-1309 (2007) (Full Text PDF ).
- Need for Speed: Mechanical Regulation of a Replicative Helicase
- Cornell researchers determine how an enzyme plays a key role in gene copying
Nanofabricated quartz cylinders for angular optical trapping: torque detection during DNA supercoiling.
C. Deufel, S. Forth, C.R. Simmons, S. Dejgosha, and M.D. Wang.
Nature Methods 4:223-5 (2007) (Full Text PDF ).
Mechano-chemical kinetics of transcription elongation.
L. Bai, R.M. Fulbright, & M.D. Wang.
Physical Review Letters 98:068103 (2007) (Full Text PDF ).
2006 Probing SWI/SNF remodeling of the nucleosome by unzipping single DNA molecules.
A. Shundrovsky, C. L. Smith, J.T. Lis, C.L. Peterson, and M.D. Wang.
Nature Structural and Molecular Biology 13:549-54 (2006) (Full Text PDF ).
Single-molecule analysis of RNA polymerase transcription.
L. Bai, T.J. Santangelo, and M.D. Wang.
Annual Review of Biophysics and Biomolecular Structure 35:343�60 (2006) (Full Text PDF ).
Detection of forces and displacements along the axial direction in an optical trap.
C. Deufel and M.D. Wang.
Biophysical Journal 90:657-67 (2006) (Full Text PDF ).
2005 Detection of high affinity mismatch binding and sliding clamp modes for the MSH2-MSH6 mismatch recognition complex by single-molecule unzipping force analysis.
J. Jiang, L. Bai, J. Surtees, Z. Gemici, M.D. Wang, and E. Alani.
Molecular Cell 20:771-81 (2005) (Full Text PDF ).
Functional hydrogel surfaces: binding kinesin-based molecular motor proteins to selected patterned sites.
T. Yu, Q. Wang, D.S. Johnson, M.D. Wang, and C.K. Ober.
Advanced Functional Materials 15: 1303-1309 (2005) (Full Text PDF ).
Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes.
B. Brower-Toland, D.A. Wacker, R.M. Fulbright, J.T. Lis, W.L. Kraus, and M.D. Wang.
Journal of Molecular Biology 346:135-146 (2005) (Full Text PDF ).
2004 A single molecule technique to study sequence-dependent transcription pausing.
A. Shundrovsky, T.J. Santangelo, J.W. Roberts, and M.D. Wang.
Biophysical Journal 87:3945-53 (2004) (Full Text PDF ).
Sequence-dependent kinetic model for RNA polymerase elongation.
L. Bai, A. Shundrovsky, and M.D. Wang.
Journal of Molecular Biology 344:335-349 (2004) (Full Text PDF ).
The molecular mechanism of transcription inhibition by Microcin J25.
K. Adelman, J. Yuzenkova, A. La Porta, J.T. Lis, S. Brukhov, M.D. Wang, and K.V. Severinov.
Molecular Cell 14:753-762 (2004) (Full Text PDF ).
Optical torque wrench: angular trapping, rotation and torque detection using quartz microparticles.
A. La Porta and M.D. Wang.
Physical Review Letters 92:190801 (2004) (Full Text PDF ).
Twisty Tweezers - Physical Review Focus Article on the Angular Optical Trap
Use of optical trapping techniques to study single nucleosome dynamics.
B. Brower-Toland, and M.D. Wang.
Methods in Enzymology: Chromatin and Chromatin Remodeling Enzymes 376:62-72 (2004). (Full Text PDF ).
2003 Dynamic force spectroscopy of protein-DNA interactions by unzipping DNA double helix.
S.J. Koch, and M.D. Wang.
Physical Review Letters 91:028103 (2003) (Full Text PDF ).
Biophysicists 'unzip' DNA technique that could aid drug development - Need for Speed: Mechanical Regulation of a Replicative Helicase
featured in archived article
- Cornell researchers determine how an enzyme plays a key role in gene copying
- Five Cornell faculty members receive Provost's Awards for Distinguished Scholarship
- Michelle Wang is first researcher on Ithaca campus to be named Hughes Institute Investigator
- Physics of gene transcription observed by CU researchers
- Researchers 'unzip' molecules to measure interactions keeping DNA packed in cells
Service
current professional activities
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- Member, American Physical Society
- Member, American Biophysical Society
event host
Background
educational background
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- B.S., Physics, Nanjing University. 1985
- M.S, Physics, University of Southern Mississippi, 1998
- Ph.D. student, Institute of Physics, Chinese Academy of Sciences, 1985-86, Ph.D., Biophysics, University of Michigan at Ann Arbor, 1993
- Postdoctoral Fellow, Biophysics, Princeton University, 1994-97
awards and distinctions listing
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- Outstanding Student Award, Nanjing University, 1985
- University of Michigan Biophysics Fellowship, 1988-89
- National Cancer Institute Fellowship, 1994
- Damon Runyon-Walter Winchell Foundation Postdoctoral Fellowship, 1995-97
- Damon Runyon Scholar Award, 1999-00. Dale F.
- Betty Ann Frey Scholar of the Damon Runyon-Walter Winchell Foundation, 1999
- Alfred P. Sloan Research Fellow, 1999-01
- Beckman Young Investigator Award, 1999-02.
- Keck Foundation Distinguished Young Scholar in Medical Research Award, 2000-07.