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Brown, William J
Cornell Faculty Member
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academic article
- PAFAH Ib Phospholipase A2 subunits have distinct roles in maintaining Golgi structure and function. BBA Mol. Cell Biol. Lipids. 1831:595-601. 2013
- A PLA1-2 punch regulates the Golgi complex.. Trends in Cel Biol.. 22:116-124. 2012
- Regulation of the Golgi complex by phospholipid remodeling enzymes.. BBA Mol. Cell Biol. Lipids. 1821:1078-1088. 2012
- COPI acts in both vesicular and tubular transport. Nature Cell Biology. 13. 2011
- The phospholipase A2 enzyme complex PAFAH Ib mediates endosomal membrane tubule formation and trafficking.. Molecular Biology of the Cell. 22:2348-2359. 2011
- A role for phospholipase A2 activity in membrane tubule formation and trafficking. . Traffic. 11:1530-1536. 2010
- Membrane topology of human AGPAT3 (LPAAT3). Biochemical Biophysical Research Communications. 397:661-667. 2010
- The phospholipase complex PAFAH Ib regulates the functional organization of the Golgi Complex.. Journal of Cell Biology. 190:45-55. 2010
- Assembly of an intact Golgi complex requires phospholipase A2 (PLA2) activity, membrane tubules, and dynein-mediated microtubule transport. Biochemical and Biophysical Research Communications. 389:473-477. 2009
- Cytoplasmic phospholipase A2 antagonists inhibit multiple endocytic membrane trafficking pathways. Biochemical and Biophysical Research Communications. 388:695-699. 2009
- Lysophosphatidic acid acyltransferase 3 regulates Golgi complex structure and function. Journal of Cell Biology. 186:211-218. 2009
- A block in endoplasmic reticulum-to-Golgi trafficking inhibits phospholipid synthesis and induces neutral lipid accumulation. Journal of Biological Chemistry. 283:25735-25751. 2008
- Adipocyte differentiation-related protein reduces the lipid droplet association of adipose triglyceride lipase and slows triacylglycerol turnover. Journal of Lipid Research. 48:2751-2761. 2007
- ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells. EMBO Reports. 7:106-113. 2006
- A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. Journal of Cell Science. 118:3061-3071. 2005
- Use of Acyltransferase Inhibitors to Block Vesicular Traffic Between the ER and Golgi Complex. Methods in Enzymology. 404:115-125. 2005
- Characterization of a novel CI-976-sensitive lysophospholipid acyltransferase that is associated with the Golgi complex. Biochemical and Biophysical Research Communications. 313:681-686. 2004
- Inhibition of membrane tubule formation and trafficking by isotetrandrine, an antagonist of G-protein regulated phospholipase A2 enzymes. Molecular Biology of the Cell. 15:1871-1880. 2004
- Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Molecular Biology of the Cell. 14:3459-3469. 2003
- Phospholipase A2 (PLA2) enzymes in membrane trafficking: mediators of membrane shape and function. Traffic. 4:214-221. 2003
- Inhibition of Endosome Tubulation and Receptor Recycling by Phospholipase A2 (PLA2) Antagonists Suggests A General Role for PLA2 in Tubule-Mediated Membrane Trafficking. Journal of Biological Chemistry. 276:47361-47370. 2001
- Phospholipase A2 antagonists inhibit constitutive retrograde membrane trafficking from the Golgi complex and TGN to the ER. Traffic. 1:504-511. 2000
- Clofibrate Inhibits Membrane Trafficking to the Golgi Complex and Induces its Retrograde Movement to the Endoplasmic Reticulum. Cell Biology and Toxicology. 15:311-323. 1999
- Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists. Molecular Biology of the Cell. 10:1763-1782. 1999
- Phospholipase A2 antagonists inhibit nocodazole-induced Golgi mini-stack formation: evidence for an ER-intermediate and constitutive recycling. Molecular Biology of the Cell. 10:4021-4032. 1999
- Stimulation of Golgi membrane tubulation and retrograde trafficking to the ER by Phospholipase A2 Activating Protein (PLAP) peptide. Journal of Cellular Biochemistry. 74:670-683. 1999
- Evidence that Phospholipase A2 (PLA2) Activity is Required for Golgi Complex and TGN Membrane Tubulation. Proceedings at the National Academy of Science USA. 95:8642-8647. 1998
- Retrograde Trafficking of Both Golgi Complex and TGN Markers to the ER Induced by Nordihydroguaiaretic acid and Cyclofenil Diphenol. Journal of Cell Science. 111:951-965. 1998
- A role for calmodulin in organelle membrane tubulation. Molecular Biology of the Cell. 6:871-887. 1995
- Characterization of a cytosolic activity that induces the formation of Golgi membrane tubules in a cell-free system. Biochemistry. 34:13359-13366. 1995
- Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. Journal of Cell Biology. 130:781-796. 1995
- Biosynthesis and intracellular transport of a membrane glycoprotein (plgp57) of the prelysosomal compartment. Molceular Membrane Biology. 11:127-134. 1994
- Microglial infection by a neurovirulent murine retrovirus results in defective processing of envelope protein and intracellular budding of virus particles. Journal of Virology. 68:3402-3409. 1994
- Inhibition of protein synthesis separates autophagic sequestration from the delivery of lysosomal enzymes. Journal of Cell Science. 105:15-24. 1993
- Tubulation of Golgi membranes in vivo and in vitro in the absence of brefeldin A. Journal of Cell Biology. 120:15-24. 1993
- Adhesion of Golgi cisternae by proteinaceous interactions: identification of intercisternal bridges as candidate adhesive structures. Journal of Cell Science. 103:773-784. 1992
- Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes. Journal of Cell Science. 102:515-526. 1992
- The morphology but not the function of endosomes and lysosomes is altered by brefeldin A. Journal of Cell Biology. 119:273-285. 1992
- Biosynthesis of lysosomal enzymes in cells of the End3 complementation group which are conditionally defective in endosomal acidification. Somatic Cell and Molecular Genetics. 17:137-150. 1991
- Brefeldin A causes a microtubule–mediated fusion of the trans Golgi network and early endosomes. Cell. 67:591-600. 1991
- Identification of a membrane glycoprotein found primarily in the prelysosomal endosome compartment. Journal of Cell Biology. 112:245-255. 1991
- Cation–independent mannose–6–phosphate receptors reside in monensin–sensitive, trans Golgi elements in normal human and I cell disease fibroblasts. European Journal of Cell Biology. 51:201-210. 1990
- Selective internalization of the apical plasma membrane and rapid redistribution of lysosomal enzymes and mannose–6–phosphate receptors during osteoclast inactivation by calcitonin. Journal of Cell Science. 97:439-447. 1990
- Polarized secretion of lysosomal enzymes: co–distribution of 215kD mannose–6–phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway. Journal of Cell Biology. 106:1863-1872. 1988
- The distribution of 215–Kilodalton mannose–6–phosphate receptors within cis (heavy) and trans (light) Golgi subfractions varies in different cell types. Proceedings at the National Academy of Science USA. 84:9001-9005. 1987
- Mannose–6–phosphate receptors for lysosomal enzymes cycle between the Golgi complex and endosomes. Journal of Cell Biology. 103:1235-1247. 1986
- Accumulation of coated vesicles bearing mannose–6 phosphate receptors for lysosomal enzymes in the Golgi region of I cell fibroblasts. Proceedings at the National Academy of Science USA. 81:5135-5139. 1984
- Redistribution of mannose–6–phosphate receptors induced by tunicamycin and chloroquine. Journal of Cell Biology. 98:320-326. 1984
- The mannose–6–phosphate receptor for lysosomal enzymes is localized in the cis Golgi cisternae. Cell. 36:295-307. 1984
- Specific and azurophilic granules from rabbit polymorphonuclear leukocytes. I. Isolation and characterization of membrane and content subfractions. Journal of Cell Biology. 96:1030-1039. 1983
- Specific and azurophilic granules from rabbit polymorphonuclear leukocytes. II. Cell surface localization of granule membrane and content proteins before and after degranulation. Journal of Cell Biology. 96:1040-1046. 1983
- Development of capping ability during differentiation of HL–60 human promyelocytic leukemia cells. Journal of Cellular Physiology. 106:127-136. 1981
- Transfer of lysosomal membrane proteins into phagosome membranes. Journal of Supramolecular Structure and Cellular Biochemistry. Suppl. 5:318. 1981
- Ultrastructural localization of cationic proteins in human polymorphonuclear leukocytes. Journal of Cell Science. 30:21-35. 1978
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booksection
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chapter
- Golgi membrane tubule formation. Cell Biology Protocols. 2006
- Immunoperoxidase methods for localization of antigens in cultured cells and tissues. Current Protocols in Cell Biology. 1998
- Immunoperoxidase methods for the localization of antigens in cultured cells and tissue sections by electron microscopy. Laboratory Methods in Vesicular and Vectoral Transport. 218-233. 1991
- Immunoperoxidase methods for the localization of antigens in cultured cells and tissue sections. Methods in Cell Biology: Vesicular Traffic. 553-569. 1989
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conference paper
- A simple, rapid method for isolating rabbit neutrophil cytoplasmic granules. Proceedings of the Electron Microscopy Society of America. 78-79. 1979
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Background
education and training
- Ph.D. in Medical Sciences, University of Texas Southwestern Medical Center 1981