Zheng, Xinmin

Cornell Faculty Member

Positions

Visiting Professor, Molecular Biology and Genetics (MBG), College of Agriculture and Life Sciences (CALS)

Understanding the mechanisms of PTPalpha-medieted Src activation may lead to development of therapeutic stragegies.

Publications
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individual publications

academic article
- Activation of Src and transformation by a RPTPα splice mutant found in human tumors. EMBO Journal. 30:3200-3211. 2011
- Extracellular domain dependence of PTPalpha transforming activity. Genes to Cells. 15:711-724. 2010
- Selective apoptosis of estrogen receptor-negative breast and colon cancer cell lines by PTPα and Src RNAi. International Journal of Cancer. 122:1999-2007. 2008
- Reconstitution of regulated phosphorylation of FceRI by a lipid raft-excluded protein-tyrosine phosphatase. Journal of Biological Chemistry. 280:1230-1235. 2005
- Low levels of glutathione peroxidase-1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in the pro-oxidant-induced aponecrosis. Biochem J.. 370:927-934. 2003
- Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation. Journal of Biological Chemistry. 277:21922-219299. 2002
- Two mechanisms activate PTPα during mitosis. EMBO Journal. 20:6037-6049. 2001
- A phosphotyrosine displacement mechanism for activation of Src by PTPα. EMBO Journal. 19:964-978. 2000
- Expression of receptor-like protein tyrosine phosphatase alpha in rat embryo fibroblasts activates mitogen-activated protein kinase and c-Jun. Journal of Biological Chemistry. 269:23302-23309. 1994
- Cell Transformation and Activation of pp60c-src by overexpression of protein tyrosine phosphatase. Journal of Biological Chemistry. 359:336-9. 1992
- Sequencing and Expression of Complementary DNA for the General Transcription factor. Nature. 344:556-559. 1990
- A General Transcription Factor Form stable Complex with RNA Polymerase B. Cell. 50:361-8. 1987
- Purification of a factor specific for the upstream element of the adenovirus-2 major late promoter. EMBO Journal. 5:2577-2584. 1986
- Comparison of the in Vitro Effect of Calf Thymus Peptide Hormone, Thymo-Peptide and Porcine Thymosin on the PNA Receptor of the Mouse Thymocytes. Microbiology and Immunology J of China. 6:15-18. 1985
- Effect of Calf Thymus Peptide Hormone on Surface PNA Receptor of Mouse Thymocytes. Immunology J of Shanghai. 5:217-221. 1985
- Quantitative Fluorescent Method to determine the Peanut Agglutinin Receptor on Mice Thymocytes. Immunology J of Shanghai. 4:197-201. 1984
- Purification and Physical-Chemical Characterization of Peanut Agglutinin Immunology. J of Shanghai. 4:65-70. 1983
- Effect of Simplified Calf Thymosin on Cyclic Nucleotide Contents and Peanut Agglutinin Receptor of Thymocytes in Mice with Atorphic Thymus. Immunology J of Shanghai. 2:36. 1982