My laboratory studies the genetics of epilepsy. We employ Drosophila as a model system for studying epilepsy. Certain classes of Drosophila mutants called bang-sensitives undergo seizures during mechanical stimulation. The bang-sensitive phenotype has several features: the flies have an initial seizure, paralyze, seize again, and then become resistant to further seizures. It is possible to select for genes that suppress or enhance any aspect of the bang-sensitive phenotype. In my lab, we plan to identify genes involved in epileptogenesis through a genome-wide screen for enhancers and suppressors of bang-sensitivity. By identifying genes in epileptogenesis, we hope to identify new drug targets by which epilepsy may be treated.

My educational focus is to meld experimental and theoretical approaches to the study of neuroscience. In my lecture and laboratory courses, there is a strong emphasis on understanding the techniques that were utilized to advance neuroscience. By placing these discoveries in their experimental context, the students have a stronger grasp of what is the current state of neuroscience knowledge.